60mg Arimidex given to male volunteers

[sade]

[Michael Scally MD]

Originally Posted by sade

How on earth could this have not caused any side effects such as low libido, ED, cracking aching joints, messed up lipids? Sounds like bullshit to me. That dosage of Arimidex would mess any man up.

ARIMIDEX�AnastrozoleTABLETS

This sounds like results from a phase 1 trial and routine. It more than likely for toxicity. This is no big deal.


Phase I trials are the first stage of testing in human subjects. Normally, a small (20-100) group of healthy volunteers will be selected. This phase includes trials designed to assess the safety (pharmacovigilance), tolerability, pharmacokinetics, and pharmacodynamics of a drug. These trials are often conducted in an inpatient clinic, where the subject can be observed by full-time staff. The subject who receives the drug is usually observed until several half-lives of the drug have passed. Phase I trials also normally include dose-ranging, also called dose escalation, studies so that the appropriate dose for therapeutic use can be found. The tested range of doses will usually be a fraction of the dose that causes harm in animal testing. Phase I trials most often include healthy volunteers. However, there are some circumstances when real patients are used, such as patients who have terminal cancer or HIV and lack other treatment options. "The reason for conducting the trial is to discover the point at which a compound is too poisonous to administer." Clinical trial - Wikipedia, the free encyclopedia

[seeking]

one dose given to normal healthy functioning males would probably not do much of anything, especially a few days later

[imrj]

weird...didnt know arimidex was on the list of abused drugs!!! maybe 60mg can get you high!!! LOL