Originally Posted by Mingle
Interesting to read your comments about the conversion to e2 as i have some concerns about this myself.
There are so many things that affect E2. There is your total T level, supplements that you take (soy, soy isoflavones, DHEA, etc), how much fat you have and probably many other things. Things like Indolplex DIM plus TMG or Arimidex
will lower E2, but if it is too low you will have the same symptoms as when it is too high, plus low E2 is bad for bone loss. There is also some evidence that it is high E2 that is responsible for some cancers in men, like prostate cancer. My E2 level has been all over the place the past 2 years, but I have taken various supplements in different doses and I believe that is the cause of the big fluctuations.
Soy is another thing that is very controversial. Many people say that soy in any form is very bad for men, and they might be right. However, there is one study that shows that soy concentrate is bad for hormone levels, but that soy isolate is beneficial. There is also some data that shows that soy isoflavones take up E2 receptor sites and result in low E2. I tried taking soy isoflavones for 2 months and my E2 plummeted from 57.2 to <20, but I also stopped taking DHEA and was taking Indolplex DIM and TMG. Too many changes at one time, so I have no idea which were responsible. Perhaps all of them. It went up to 34.4 three months later when not taking any of those supplements. I now avoid the soy, except for a combination whey/soy isolate shake on days that I lift weights. There are several studies that show that the soy isoflavone genistein is beneficial to estrogen balance, stopping bone loss and possibly helping in breast cancer in women, so it could have positive effects in men, but there is no real information to show either way. It is just another one of those things that might have significant advantages and disadvantages.
It seems that getting your hormones just right is a never ending struggle, but then perhaps it is just those who are having fluctuations who write on boards like this. Perhaps there are millions who just slap on the Androgel
or Testim and feel great and are completely happy with it.