Clomiphene increases free testosterone levels in men

[cvictorg]

[Michael Scally MD]

I am not sure if you realize that you are asking a very good question as regards to PCT! In other words, are SERMs (or AI) useful for raising T level when administered with other AAS? NO. How would SERMs (or AI) act to raise gonadotropins when the HPTA is being suppressed actively.

[James23]

My doctor has me using Clomid exclusively. 15mg-30mg EOD.

It did raise both free and total testosterone, but I experienced no subjective benefits. I feel worse than when I started.

[HeadDoc]

Originally Posted by James23

My doctor has me using Clomid exclusively. 15mg-30mg EOD.

It did raise both free and total testosterone, but I experienced no subjective benefits. I feel worse than when I started.

I looked at a few studies on this topic and found that where a positive increase in testosterone occured, clomid was not used indefinitely. From reading some of the posts by members undergoing PCT, there are various reports of depressive feelings and sometimes visual problems. Both are reported to remit with discontinuation of clomid. I haven't looked at the literature to validate the last observation.

[martypa]

Dr Scally

What do you think of using SERMs or AI's for sole treatment of secondary hypogonadism?

[Michael Scally MD]

Originally Posted by martypa

Dr Scally

What do you think of using SERMs or AI's for sole treatment of secondary hypogonadism?

At this time, I think the long-term use of SERMs or AI should be restricted to a research setting. It does not mean their use should be avoided. i used them often.

There are companies exploring the long term use of SERMs.

Gtx (GTx. Hormone pathways to treat cancer, bone loss, muscle wasting) is researching the use of toremifene for prevention of bone loss in androgen deprivation therapy in prostate cancer.

RPRX (Repros Therapeutics) and QUATRx (QuatRx Pharmaceuticals) are investigating the use of enclomiphene and fispemifene, respectively, for use in secondary hypogonadism.

The FDA has stated that the use of non-testosterone therapies to replace testosterone treatment is an unacceptable indication at this time!!!

[m_ob]

I really like the idea of long-term SERM usage for those who respond well.

[CubbieBlue]

Originally Posted by m_ob

I really like the idea of long-term SERM usage for those who respond well.

Eventually. What is out now is not a long term answer.

[Fecal McAngry]

Originally Posted by Michael Scally MD

I am not sure if you realize that you are asking a very good question as regards to PCT! In other words, are SERMs (or AI) useful for raising T level when administered with other AAS? NO. How would SERMs (or AI) act to raise gonadotropins when the HPTA is being suppressed actively.

Based on this study I'd expect *some* SERMs, specifically tamoxifen, clomiphene and perhaps toremifene to act in an hCG-like fashion while on cycle with testosterone (or other androgens which suppress the HPTA largely via increased estrogen [apparently tamoxifen can raise LH even in the presence of a lot of excess estrogen])...

Testicle size worries? Try a course of Nolvadex + Andriol

I'd expect enclomiphene to be popular both on and off cycle (PCT) if it is ever released, as it sounds like the test-boosting SERM from heaven ("More potent than Clomid with NO weepy SX!); unfortunately, all the current SERMs suck from my perspective (Okay, I've only tried three)...

[m_ob]

Which is why one checks their Lh, Test, and estrogen status before running the clomid.