Evista/Nolvadex for osteoporsis and gyno

[2yung4this]

So, recap of before...have bad osteoporosis, on trt and high estradiol which in turn gave me gyno. doc wont give Adex because of estrogen's positive affect on bone. Would Evista (ralfaxone?) or nolvadex turn off the estrogen receptors in my chest while leaving the ones in my bones alone?

Would they have feminizing effects?

Any idea guys?

[Michael Scally MD]

Originally Posted by 2yung4this

So, recap of before...have bad osteoporosis, on trt and high estradiol which in turn gave me gyno. doc wont give Adex because of estrogen's positive affect on bone. Would Evista (ralfaxone?) or nolvadex turn off the estrogen receptors in my chest while leaving the ones in my bones alone?

Would they have feminizing effects?

Any idea guys?

Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr 2004;145(1):71-6.

OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.

[2yung4this]

I get that the drugs would be good for preventing/treating gyno..but would They leave the estrogen receptors in my bones alone? The way i understand it, Adex slows/stops the conversion of test to estrogen which would inhibit my bone protection, correct?