Finasteride [5ARI] Induced/Associated Adverse Effects

Discuss Finasteride [5ARI] Induced/Associated Adverse Effects at the Men's Health Forum; Hi guys, I've been lurking for awhile but the time has come for me to post... I really need your ...

Go Back   MESO-Rx > Medicine > Men's Health Forum


Like Tree5Likes

Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 12-19-2006, 12:53 AM
Junior Member
 
Join Date: Jun 2006
Posts: 28
Default Finasteride [5ARI] Induced/Associated Adverse Effects

Hi guys, I've been lurking for awhile but the time has come for me to post... I really need your help, PLEASE. I don't know what to do anymore and my health and quality of life has been ruined thanks to Finasteride.

LAB ATTACHMENTS ARE INCLUDED IN THIS POST.

I am 27 years old, 5'10, 150lbs. I took Finasteride (Proscar) quartered 1.25mg/day for 11 months when I was 25-26 for hairloss. It has now been 14 months since I quit (cold turkey) and I have still not recovered from the side effects I experienced. This was after I was told by my doctor and MERCK's literature that any side effects would resolve upon discontinuation of the drug.

Prior to Finasteride I was a perfectly healthy 25 yr old guy, I loved to have sex, could get hard at the drop of a hat, was always horny and mentally sharp. Now a year and a half later I'm a shell of my former self, and am STILL experiencing side effects that manifested while on the drug, including:


Sexual:
---------
- Low libido, no primal desire for sex, never horny
- No spontaneous, morning or nocturnal erections
- Numb feeling/lack of sensitivity in penis/balls, rubbery penis
- Penis/nuts extremely wrinkled when flaccid, constantly retreating
- Penile/scrotum shrinkage
- Porn/girls don't turn me on anymore (nothing happens down there)
- Some penis curvature and rotation on axis to left
- Semen volume/shooting distance decrease
- Semen consistency change from thick creamy white before fin, to clear and watery while on fin.... after fin, semen is somewhat thick and sheet yellow/white in color.
- Loss of erections soon after penetration, unable to sustain


Mental:
--------
- Brain fog, difficulty remembering things, forgetfulness
- Stumbling over words, tongue tied, slurring of speech
- Emotional blunting / no feelings
- Lack of energy, interest in hobbies, no passion to do anything anymore


Physical:
--------
Pseudo-gyno


When I quit on October 1, 2005, my dick was shrivelled, totally numb and tingly, and completely lifeless... I couldn't feel anything down there anymore. I couldnt get turned on, my jizz was like water and I felt like I was constantly out of it mentally, and always tired. Also by this point I was experiencing full-blown panic attacks, anxiety, weight gain and the beginnings of puffy nips/gyno (I had major chest pains in month 6 -- should have recognized the signs).

2 weeks after I quit I felt a massive flood of DHT come back into my system. I felt horny and alive again!!! I could get turned on no problem, erections were 100%, jizz volume great, penis/balls were full size.

3 months later by January 2006, the flood of DHT had disappeared and I felt like complete crap... my system had crashed. At this point I got my first labs drawn.


LABS (Canadian values):
-----------------------

1. January 2006 (3 months off):
- low T (12.8 nmo/L, range 8.4-28.7 = 388 in US)
- high TSH (4.54, range 0.30-5.50).

Family doctor refused to believe Finasteride could be causing these problems, said everything was in my head. I knew it wasn't and by this point I had found the Yahoo Finasteride Side Effects forum. I came to realize there were hundreds of other men who had their HPTA screwed by finasteride, and have yet to recover.

2. May 2006 (8 months off) - 2nd blood test:
- T went up to 17.3 (519)
- TSH went down to 2.33
- Estradiol 154 (43 US terms)
- LH 2.0 (2.0-18) ... BORDERLINE
- FSH 2.1 (2.0-18) ... BORDERLINE
- Also had a semen test - came back fertile.

I realized at this point I was experiencing symptoms of secondary hypogonadism. Again my doctor shrugged things off and told me to come back in 6 months.


TODAY:
--------

December 2006 (14 months off):

- Have since seen a world-reknowned Urologist who basically told me this was all in my head and claimed all my values were "normal", yet found it "interesting" that I had no morning, noctunals or spontaneous wood.
- Prescribed me Viagra (at 27!!!) and sent me on my way.

Even though its been 14 months since I quit, I am still experiencing all of the above side effects, and nothing has really improved. My main issue is still the lack of sex drive, penis/nuts shrinkage, reduced ejaculate and difficulty getting erections (due to lack of libido).

I am seeing another local Endo in March but may get new labs before then (they cost me $) to check Estradiol, Total T, TSH, LH, FSH, Prolactin, Progesterone, SHBG, DHT, AST, ALT, DHEA-s, Cortisol, Albumin, and Free Testosterone.

--------------

TREATMENT HELP:

Well, here's where I need your guys' help and expert opinions...

Basically... HOW CAN I GET BACK TO NORMAL? I understand HCG and Clomid can be used to jumpstart the HPTA... but for how long after you've been shutdown? Does anyone even know how or why Fin screws up the HTPA in the first place (besides blocking DHT/T upregulation/extra aromatization to E?)

Based on my last labs, my best guess is to get my Estradiol under control (apparently its high?) to correct the T/E ratio, and see where Prolactin and SHBG are with my next labs. I understand the former can shutdown T production/the latter binds Free T, which is crucial for libido. Hopefully by correcting those hormones LH will be stimulated and T/FSH will rise again?

However, eventually I think I will make an appointment to see Dr John or Shippens in the US. I understand they have experience treating men shutdown my Fin... but if anyone knows a doctor or endo in Canada that has treated Finasteride patientsthen please let me know... I really don't want to have to resort to going on TRT for life (if I could even find a doc willing to work with me on it).


Thanks in advance for any and all insight, I feel like a shell of my former self but I know there must be a way to beat this.

You guys are the best.

Last edited by Michael Scally MD; 03-26-2011 at 08:32 PM.
Reply With Quote
  #2  
Old 12-19-2006, 04:54 AM
Legenden1999's Avatar
Senior Member
 
Join Date: Mar 2005
Posts: 153
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high E

Quote:
Originally Posted by madclown
Hi guys, I've been lurking for awhile but the time has come for me to post... I really need your help, PLEASE. I don't know what to do anymore and my health and quality of life has been ruined thanks to Finasteride.

LAB ATTACHMENTS ARE INCLUDED IN THIS POST.

I am 27 years old, 5'10, 150lbs. I took Finasteride (Proscar) quartered 1.25mg/day for 11 months when I was 25-26 for hairloss. It has now been 14 months since I quit (cold turkey) and I have still not recovered from the side effects I experienced. This was after I was told by my doctor and MERCK's literature that any side effects would resolve upon discontinuation of the drug.

Prior to Finasteride I was a perfectly healthy 25 yr old guy, I loved to have sex, could get hard at the drop of a hat, was always horny and mentally sharp. Now a year and a half later I'm a shell of my former self, and am STILL experiencing side effects that manifested while on the drug, including:


Sexual:
---------
- Low libido, no primal desire for sex, never horny
- No spontaneous, morning or nocturnal erections
- Numb feeling/lack of sensitivity in penis/balls, rubbery penis
- Penis/nuts extremely wrinkled when flaccid, constantly retreating
- Penile/scrotum shrinkage
- Porn/girls don't turn me on anymore (nothing happens down there)
- Some penis curvature and rotation on axis to left
- Semen volume/shooting distance decrease
- Semen consistency change from thick creamy white before fin, to clear and watery while on fin.... after fin, semen is somewhat thick and sheet yellow/white in color.
- Loss of erections soon after penetration, unable to sustain


Mental:
--------
- Brain fog, difficulty remembering things, forgetfulness
- Stumbling over words, tongue tied, slurring of speech
- Emotional blunting / no feelings
- Lack of energy, interest in hobbies, no passion to do anything anymore


Physical:
--------
Pseudo-gyno


When I quit on October 1, 2005, my dick was shrivelled, totally numb and tingly, and completely lifeless... I couldn't feel anything down there anymore. I couldnt get turned on, my jizz was like water and I felt like I was constantly out of it mentally, and always tired. Also by this point I was experiencing full-blown panic attacks, anxiety, weight gain and the beginnings of puffy nips/gyno (I had major chest pains in month 6 -- should have recognized the signs).

2 weeks after I quit I felt a massive flood of DHT come back into my system. I felt horny and alive again!!! I could get turned on no problem, erections were 100%, jizz volume great, penis/balls were full size.

3 months later by January 2006, the flood of DHT had disappeared and I felt like complete crap... my system had crashed. At this point I got my first labs drawn.


LABS (Canadian values):
-----------------------

1. January 2006 (3 months off):
- low T (12.8 nmo/L, range 8.4-28.7 = 388 in US)
- high TSH (4.54, range 0.30-5.50).

Family doctor refused to believe Finasteride could be causing these problems, said everything was in my head. I knew it wasn't and by this point I had found the Yahoo Finasteride Side Effects forum. I came to realize there were hundreds of other men who had their HPTA screwed by finasteride, and have yet to recover.

2. May 2006 (8 months off) - 2nd blood test:
- T went up to 17.3 (519)
- TSH went down to 2.33
- Estradiol 154 (43 US terms)
- LH 2.0 (2.0-18) ... BORDERLINE
- FSH 2.1 (2.0-18) ... BORDERLINE
- Also had a semen test - came back fertile.

I realized at this point I was experiencing symptoms of secondary hypogonadism. Again my doctor shrugged things off and told me to come back in 6 months.


TODAY:
--------

December 2006 (14 months off):

- Have since seen a world-reknowned Urologist who basically told me this was all in my head and claimed all my values were "normal", yet found it "interesting" that I had no morning, noctunals or spontaneous wood.
- Prescribed me Viagra (at 27!!!) and sent me on my way.

Even though its been 14 months since I quit, I am still experiencing all of the above side effects, and nothing has really improved. My main issue is still the lack of sex drive, penis/nuts shrinkage, reduced ejaculate and difficulty getting erections (due to lack of libido).

I am seeing another local Endo in March but may get new labs before then (they cost me $) to check Estradiol, Total T, TSH, LH, FSH, Prolactin, Progesterone, SHBG, DHT, AST, ALT, DHEA-s, Cortisol, Albumin, and Free Testosterone.

--------------

TREATMENT HELP:

Well, here's where I need your guys' help and expert opinions...

Basically... HOW CAN I GET BACK TO NORMAL? I understand HCG and Clomid can be used to jumpstart the HPTA... but for how long after you've been shutdown? Does anyone even know how or why Fin screws up the HTPA in the first place (besides blocking DHT/T upregulation/extra aromatization to E?)

Based on my last labs, my best guess is to get my Estradiol under control (apparently its high?) to correct the T/E ratio, and see where Prolactin and SHBG are with my next labs. I understand the former can shutdown T production/the latter binds Free T, which is crucial for libido. Hopefully by correcting those hormones LH will be stimulated and T/FSH will rise again?

However, eventually I think I will make an appointment to see Dr John or Shippens in the US. I understand they have experience treating men shutdown my Fin... but if anyone knows a doctor or endo in Canada that has treated Finasteride patientsthen please let me know... I really don't want to have to resort to going on TRT for life (if I could even find a doc willing to work with me on it).


Thanks in advance for any and all insight, I feel like a shell of my former self but I know there must be a way to beat this.

You guys are the best.
I just want to tell you that you are not alone. I have basicly the same symptoms, but for me the mental part (brain fog/lack of emotions) is the worst. I have been off finasteride for 3 years I think, and my symptoms presist.

Im sorry to inform you this, but for us finasteride-sufferes, there seems to be much more going on in our bodies than just a screwed up HPTA.

I have tried clomid treatment for 2 months, which raised my T very well, but after a few months off it, my T fell down again. I did not notice much improvement while on it. To make matters worse I go permanent floaters in my left eye from clomid :-(

Some time later I tried TRT for 3 months. It helped on my energy level and raised my libido. Sex was also improved somewhat, but my mental sides were unaffected. I stopped after 3 months cuz I rather wanted to find the root cause, that patch up with TRT and risk becomming dependent on it. I ran a PCT with nolvadex (pretty much the same as clomid) and this time I did not get any eye problems.

A few months ago I found out I have severe adrenal fatigue (took a saliva test), Both my dhea and cortisol is low and Im in stage 7, so action was required. I got my doc to prescribe Hydrocortisone 30mg/day and have currently been on it for 2 months. I dont feel much improvement, but my thyroid labs are also pretty bad, so I think I need armour also.

I have reached the point, that Im willing to replace whatever hormone in my body just to feel better, and Im currently working on it in this order:

adrenal hormones. cortisol/dhea
thyroid hormones. T3/T4
sex hromones. testosterone/E2

I advise you to get the saliva test to see what is going on with your adrenal/hyroid hormones before you jump on TRT, and you can send me a PM to get my mailadress, cause I would to keep in touch since we share so many symptoms...

JH
Reply With Quote
Sponsored Links
  #3  
Old 12-19-2006, 08:43 PM
Senior Member
 
Join Date: Nov 2006
Location: Las Vegas Area
Posts: 102
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high E

Interesting post.

I took Finasteride for hair loss and lost the hair anyway (back in 1997) and am now on TRT. The dude that is treating me thinks that this could be part of why I have the problem.
Reply With Quote
  #4  
Old 12-19-2006, 11:38 PM
Senior Member
 
Join Date: Oct 2006
Posts: 114
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high E

With an Estradiol level at 43, you are going to feel better getting it down. It will raise your T level also. When your system sees the E2, it can't tell the difference between it and T. This keeps your LH and FSH down and therefore your T level down. Try some DIM or arimidex or Zinc at the least to get your E2 down.
Reply With Quote
  #5  
Old 12-28-2008, 12:59 PM
Junior Member
 
Join Date: Dec 2008
Posts: 3
Question Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

Madclown & Legenden1999,

I'm in the exact same boat too (thanks to finasteride)!! Identical!!
- low (out of range) T
- penis & ball shrinkage
- soft unsustainble erections
- unusual breast pains for about a month
- ball ache

It's been a year now, I'm stuck like this...has anything worked for you guys.

Please help,

Propeciahell.
Reply With Quote
  #6  
Old 12-28-2008, 01:46 PM
Veteran Member
 
Join Date: Apr 2006
Posts: 2,790
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

Finasteride is a water over the dam.
It is in the past, can't change past.

To have a life now, I suggest thorough testing and adjusting what can be adjusted.
Also stay away from Clomid and Nolvadex.
Also when using Aromatase Inhibitor use only
Arimidex(pills)=LiquiDex(liquid)=Anastrozole(liqui d)
Saliva testing only for cortisol?DHEAs
Otherwise use mostly serum and some urine tests.
Stool and hair tests are helpfull.

I publish list of tests that I do for my self, if someone need I can repost.
.
.
Reply With Quote
  #7  
Old 12-29-2008, 04:20 PM
Member
 
Join Date: Dec 2008
Location: USA
Posts: 83
Send a message via Skype™ to oneday
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

I stopped taking propecia 2 yrs ago and it has fucked up my HPTA. Initially, i was unable to have erections and no desire for sex. With the help of ZMK, sustain alpha, toco, and endoamp has restored my ability to have erections to 70-85%. I have not gotten those throbbing erections that I use to get like i did 3 yrs ago. My lab work just shows that I have low free testosterone and low normal total testosterone, so I have been searching around for the proper pct protocol to bring me back to 95-100%

I've looked around and found that van-man's protocol looks promising, so i will be persuing that over the next 8 weeks.

starting day 1:
1. 20/20/20/20/20/20/10/5/2.5 gm of Nolvadex at 10pm (7-8 week program)
- helps to increase LH and FSH as well as increase the sensitivity of the Pituitary to
GnRH
- i bought clomid online but won't be taking it due to the side effects. i have been reading
research that shows that clomid reduces the pituitary sensitivity
to GnRH. So it means that it takes more GnRH to stimulate LH production, therefore it will be
harder for u to jumpstart your HPTA.

2. 250 IU HCG every other day at 10pm for 2-3 weeks
- brings the balls from atrophy, but at this amount it will not desensitize the testes

So far, I have been on this protocol for 3 days and I have noticed that I have 2 pimples on my face and my nuts are slightly bigger. It is firmer to the touch and I have been feeling my nuts several days prior to PCT b/c I wanted to be able to perceive if there were changes.

Like many finasteride users who tried various PCT protocols, all seem to fail either because they use too much HCG, not tapering off nolvadex correctly, or using clomid for too long, but after much research i think this is a winning protocol.

It is fucked up how finasteride can wreak havoc on our HTPA and now, we have to figure stuff out for ourselves. It is not an easy journey, but a necessary one that we have to take so we can get better. Wish me luck!
Reply With Quote
  #8  
Old 12-29-2008, 04:59 PM
s0b s0b is offline
Senior Member
 
Join Date: Jul 2007
Posts: 154
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

Look my life is ruined due to finasteride, and i only took it for 1 month or 5 weeks as far as i can remember.

As soon as i quit (2 weeks later in precise) all HELL BROKE LOOSE. Balls started to ache, dick started to loose sensitivity, sperm started to decrease in quantity and fade in quality and so on. Finally i was left with 2/3 of my previous ball size and 4-5 cm decrease in penis size. I didnt have sex for 2 straight years. Not even a BJ. Not even felt anything about it.

Then i started training very hard, quit smoking and anything that affected my health. Well, guess what, within 1 year i was very strong and managed to get back some of penile sensitivty , BUT NOT BALL SIZE. By 2 years time training heavily, squatting, playing bball i had restored 70% of my sexual function. If i quit training for 2-3 weeks things went bad again. If i quit taking whey protein and carbos things got bad also.

Finally so much training started to hit me along with me wokring and studying all day long, since in order to recover from stressful situations you need normal testo levels, which i didnt have after fin and i was trying to reach!!! Dahh..

So soon i started getting boots of fatigue which i coudlnt explain. I couldnt recover readily from training any more.I developed overtraining twice in 4 months, second time led me to heavy dysautonomia and adrenal fatigue. Adrenal fatigue was not handled properly here by greek docs and ended up screwing up completely my body. Now i have Chronic Fatigue Syndrome full blown. ALL MY HORMONES ARE VERY LOW. MY balls recently got screwed up for uknown reason more and are SO FUCKING SMALL AND SO SOFT. I cant even touch them.

Anyways, i dont know what to do. I tried many drugs, unfortunately i am so unlucky i had to take CIPRO ony year ago and then i urgently took HYDROCORTIONE as well and this fucked me even more, side effects have not gone away, CIPRO caused me increased intracranial pressure and tendon problems eye problems (double vision, floaters), dizziness for months and for sure it fucked my axis even more. Just after cipro it was that my balls got even smaller than before noticeably this time for even doctors.I am in bed for more than 2 years now MOST days i dont have the energy to even ride my bike around my building, -walking is very hard to do and it messes up my head pressure and i have to stay in bed for days with headaches- somedays i feel i should just jump off the building

ONE DRUG AND YOUR LIFE CAN BE SOOO OVER.

Now if there is a chance to recover from all this somehow i guess i need to heal my prostate first from the finasteride damage and then head for restoring the HPT axis with hcg and novla. But can those two work while i have so low cortisol levels? Will they bring my cortisol levels up more or will i get some more sides ???

Yet it seems that i have been in the same situation with no improvement for more than 6 months now. Its like i have hit the roof of restoration with natural ways.

STAY AWAY FROM FINASTERIDE. ITS NO JOKE DRUG. I KNOW 20 PEOPLE AT LEAST THAT HAVE TAKEN IT, DOCTORS INCLUDED AND YEARS LATER THEIR LIFE STARTED TO FALL APART. THE BODY DOESNT SEEM TO ADAPT TO THE CHANGES THE DRUG CAUSES AND THEY ARE PERMANENT

Last edited by s0b; 12-29-2008 at 05:04 PM.
Reply With Quote
  #9  
Old 12-29-2008, 05:05 PM
Member
 
Join Date: Dec 2008
Posts: 74
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

Why take HCG...what does it do?

Are the bad effects of Finasteride and Avodart the same?

Why not take Proviron instead of Nolvadex?

Read: Anti-estrogen useage to protect your physique and physiology
Reply With Quote
  #10  
Old 12-29-2008, 05:07 PM
s0b s0b is offline
Senior Member
 
Join Date: Jul 2007
Posts: 154
Default Re: Help me please -- Finasteride-induced secondary hypogonadism, low T/LH/FSH, high

I am very confused lately due to my testosterone saliva levels. They seem to be very very low, while blood levels are in normal range (yet at the lowerr 1/3d of normal)

Saliva levels are like 36 pg/ml with normal being 60-110 and estrogen levels are 11pg/ml with normal 1-3!!! Can this provide with some accuracy?? Because if there is accuracy in this situation then all those blood tests i have been doing are just a bunch of crap and are just misguiding me like it was done with adrenal fatigue and cortisol/dhea levels
Reply With Quote
Reply

Thread Tools
Display Modes

LinkBacks (?)
LinkBack to this Thread: http://thinksteroids.com/forum/mens-health-forum/finasteride-5ari-induced-associated-134248317.html
Posted By For Type Date Hits
Life threatening finasteride effects - UK-Muscle Body Building Community - Bodybuilding Forum This thread Refback 01-02-2009 07:05 PM 52

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On



All times are GMT -4. The time now is 03:34 AM.



Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2014, vBulletin Solutions, Inc.