It will start to work fast but only lowers 70% on the first pill. I tried to get my E2 down from 90 taking .5 mgs every otherday in 4 weeks did a test
and nothing. So we upped it to .5 everyday and in 2 week my levels started to come down. First thing that happened was my ED got 80% better and I could have sex with out using a pump or taking a pill. And I had not had an orgasm for over 10 yrs this came back.
Effect on Estradiol: Mean serum concentrations of estradiol were
evaluated in multiple daily dosing trials with 0.5, 1, 3, 5, and 10
in postmenopausal women with advanced breast cancer.
Clinically significant suppression of serum estradiol was seen with
all doses. Doses of 1 mg and higher resulted in suppression of mean
serum concentrations of estradiol to the lower limit of detection
>The recommended daily dose, ARIMIDEX
1 mg, reduced estradiol by
>within 24 hours and by approximately 80% after 14 days of daily
dosing. Suppression of
>serum estradiol was maintained for up to 6 days after cessation of
daily dosing with ARIMIDEX 1 mg.