05-20-2009, 06:39 PM
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Join Date: Mar 2009
| | Re: Letro equivalent for a-dex for TRT
Originally Posted by BBC3
It also looks like Letro may indeed have some "restart" capability.:
Other Endocrine Effects: Exemestane does not bind significantly to steroidal receptors,
except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone).
The binding affinity of its 17-dihydrometabolite for the androgen receptor, however, is 100-
times that of the parent compound. Daily doses of exemestane up to 25 mg had no
significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or
17-hydroxyprogesterone, and were associated with small decreases in circulating levels of
testosterone. Increases in testosterone and androstenedione levels have been observed at
daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin
(SHBG) has been observed with daily exemestane doses of 2.5 mg or higher. Slight,
nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating
hormone (FSH) levels have been observed even at low doses as a consequence of feedback at
the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free
triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH)].
Coagulation and Lipid Effects: In study 027 of postmenopausal women with early breast
cancer treated with exemestane (N=73) or placebo (N=73), there was no change in the
coagulation parameters activated partial thromboplastin time [APTT], prothrombin time [PT]
and fibrinogen. Plasma HDL cholesterol was decreased 6–9% in exemestane treated patients;
total cholesterol, LDL cholesterol, triglycerides, apolipoprotein-A1, apolipoprotein-B, and
lipoprotein-a were unchanged. An 18% increase in homocysteine levels was also observed in
exemestane treated patients compared with a 12% increase seen with placebo
BBC, i think u might be mistaken here. my understanding is that Arimidex (Anastrozole) and Femara (Letrozole) share the same mechanism of action, and that Aromasin (Exemestane) is the only *suicide* aromatase inhibitor among the three.
also, the Letrozole profile here on Meso suggests that Letro is much more estrogen-suppressive than Adex, microgram for microgram, or milligram for milligram.