Letrozole is liver toxic?

Discuss Letrozole is liver toxic? at the Men's Health Forum; Letrozole induces hepatotoxicity without causing o... [Gynecol Endocrinol. 2010] - PubMed result They used a high dose, but all liver ...

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Old 06-10-2010, 02:38 PM
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Default Letrozole is liver toxic?

Letrozole induces hepatotoxicity without causing o... [Gynecol Endocrinol. 2010] - PubMed result

They used a high dose, but all liver enzymes were elevated. They say melatonin reversed the hepatic toxicity, but if I'm not mistaken, melatonin reduces T.
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Old 06-10-2010, 03:04 PM
Michael Scally MD's Avatar
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Default Re: Letrozole is liver toxic?

It means nothing for human use.

Aydin M, Oktar S, Ozkan OV, Alcin E, Ozturk OH, Nacar A. Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin. Gynecol Endocrinol.
Letrozole induces hepatotoxicity without causing o... [Gynecol Endocrinol. 2010] - PubMed result

Aim. The aim of this study was to determine the effects of letrozole (LTZ), an aromatase inhibitor (AI), and melatonin (MLT) on hepatic function and oxidative stress in female rats.

Material and methods. A total of 32 female rats were divided equally into four groups (n = 8). Control group received saline (0.5 ml/day, oral gavage). LTZ was administered to rats by daily oral gavage at 1 mg/kg dose. LTZ + MLT group was given LTZ (1 mg/kg, oral gavage) plus MLT (0.5 mg/kg/day, s.c.). MLT group was given MLT (0.5 mg/kg/day) by s.c. injection. The activities of superoxide dismutase (SOD) and catalase (CAT) and malondialdehyde (MDA) levels were measured in liver tissue. Total antioxidant capacity (TAC), total oxidant status (TOS), ALT, AST, GGT, ALP, LDH, bilirubin, BUN, creatinine, total cholesterol (TC), high-density lipoprotein (HDL) and triglyceride (TG) were assayed in serum samples.

Results. The oxidative stress parameters did not differ between groups. LTZ administration increased hepatic function parameters such as AST, LDH, ALP, bilirubin and MLT improved the disturbances of hepatic function. LTZ caused minimal histological changes in liver tissue and MLT treatment reversed those dejenerations.

Discussion. LTZ may cause hepatotoxicity without inducing oxidative stress and MLT restores hepatic activity.
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