Originally Posted by SWALE
The idea behind use of a "biomarker" is that assay of a test
matrix, be it blood, saliva, urine (etc) will correlate (in a positive or negative manner) with a given clinical response.
For instance, serum levels of DHT
, to be useful in our endeavors here, would have to equate with the androgenic state of the guy the blood came from. Unfortunately, there is often a mismatch between serum levels and tissue levels (which is where the rubber hits the road).
What are we left with? The results of serum DHT
levels which make me think "that's interesting". IOW, it is just another piece of the puzzle.
This is part and parcel of why thee ratios have no use, IMPO, as a treatment goal.
And this is also why we cannot draw valid estrogen assay while on a SERM
I hope this explanation helps.
This is becoming a real educational link, very interesting!
OK, I think I got it (but correct me if I'm wrong): I am on 250 mg T enanthate every 10 days for 7 months now. My doc has added 0,25 mg Adex
every 3 days because my E2 was at 37 pg/ml. At this point, we did some bloodwork (still no virilisation occured in the past 7 months).
Total T: 417 ng/dl (280 - 1100)
LH: <0,2 IU/l (1,1 - 8,8)
E2: <20 ng/l (0-44) (morning wood still OK) Test
binding globuline: 8 nmol/l (13-71)
Free T calculated: 136,84 pg/ml (50-280)
Androstanediolgluceronide 31,8 ng/dl (3,4-22)
If we compare these biomarkers to my androgenic state, one should conclude that my virilisation should be 'on its way': the high value of androstanediol gluceronide shows that DHT
is getting metabolised in my cells.
I'm almost doing as much T as a beginner's cycle of AAS. But my total T is only at 417 ng/dl.
So where does all the Testosterone
that I inject go to??? Can it get flushed out of my system?? And what is preventing the virilisation process? IMHO it can't be a shortage in the number of androgen receptors, because the androstanedionegluceronide is abundant? So what other conclusion is there to make?
I know these are tough questions, but HEY: the guys on this forum are the top guns of HRT!