Originally Posted by Tim Max
Dr. Merocla I don’t know about, but why rectum is not viable option for DHEA and Progesterone delivery, same way as sublingual and creams are? It goes without saying that it will be absorbed/converted differently in each case; stomach, rectum, cream or sublingual.
There are many different medicines that are administered via rectum.
I have read in several other sources that there really is not consensus as far as to what DHEA converts into in stomach.
Well, there can always be a person such as perhaps Dr Mercola who will disagree, without any evidence to support the disagreement, and then there is not consensus.
But the metabolism of DHEA is well understood. It is for example stable to stomach acid.
It's not a question as to whether rectal absorption is viable, it's a question of whether there is a reason.
I would not assume that changing the mode of administration of DHEA will change your outcome. I would instead be concerned that higher-percentage absorption of DHEA rectally could increase your problem.
Does Dr Mercola state that individuals who experience arrhythmia with DHEA taken orally do not experience it when taken rectally? Now if he has actually observed this then perhaps there is a reason. But if he has not, it sounds like potentially dangerous speculation that changing the mode of administration to a higher-bioavailability method would decrease your problem.
Personally I tend to wonder if the observed problems some have had with this, at very low doses of DHEA, are a result of impurities in very poor quality product. But that is only speculation. My reason for it however is that far higher oral doses have been studied medically, with different DHEA material, without this problem. And by far higher, I mean over 1000 mg/day.
It could be the case that a pharmaceutical product, by virtue of being pure, might not have adverse side effects seen with cheapest-possible-manufactured Chinese material.
However, I do not know that impurities are the cause of this effect. I offer it only as a possibility.