Testosterone Research Studies

Those of you who want to help advance the understanding of testosterone use for different conditions can join research studies that are currently enrolling. I was amazed to see how many studies are out there! However, none are looking at long term management of side effects like polycythemia with therapeutic phlebotomy, testicular atrophy with long term or cycled HCG therapy, HPGA normalization protocols using HCG+Clomid+estrogen blockers, and other important modalities that are being used by many physicians but with little controlled data.

Remember that some studies have placebo arms. Every study requires for you to read and sign a consent form that should clearly describe the risks and implications in joining the study. Make sure that the private investigator or research nurse overseeing the study explains things to you clearly.

Study to Determine the Long-Term Effects of Testosterone Replacement in Men

Unfortunately, there have been no controlled studies on the long-term use of testosterone replacement in men, even though many of us have been using it for over 20 years.

To answer questions about the long-term effect of testosterone replacement therapy in men the National Institute on Aging, part of the National Institutes of Health, announced in November 2009 the start of a large-scale clinical trial to evaluate the effect of testosterone therapy in older men. Led by researchers at the University of Pennsylvania School of Medicine and conducted at 12 sites across the nation, the testosterone trial involves 800 men aged 65 years and older with low testosterone levels. The testosterone trial includes five separate studies. Men aged 65 years and older with low serum testosterone and at least one hypogonadal condition (anemia, decreased physical function, low vitality, impaired cognition, or  reduced sexual function) are randomly assigned to participate in a treatment group or a control group.

Treatment groups are given a testosterone gel that is applied to the torso, abdomen, or upper arms. Control groups will receive a placebo gel. Serum testosterone will be measured monthly for the first three months and quarterly thereafter for up to one year. Participants will be tested on a wide range of measures to evaluate physical function, vitality, cognition, cardiovascular disease, and sexual function.

Volunteering for a trial can really help advance research. Men interested in finding out more about participating in the study should call one of the following institutions:

  • University of California, Los Angeles; 310-222-5297
  • University of California, San Diego; 877-219-6610
  • Boston University; 617-414-2968
  • University of Pittsburgh; 800-872-3653
  • Albert Einstein College of Medicine, Bronx, N.Y.; 718-405-8271
  • Baylor College of Medicine, Houston, Texas; 713-798-8343
  • University of Minnesota, Minneapolis; 612-625-4449
  • Yale University, New Haven, Conn.; 203-737-5672
  • University of Alabama at Birmingham; 205-934-2294
  • VA Puget Sound Health Care System and University of Washington
  • School of Medicine, Seattle; 206-768-5408
  • Northwestern University, Evanston, Ill.; 877-300-3065
  • University of Florida, Gainesville; 866-386-7730, 352-273-5919
Testosterone Replacement Therapy - TRT

Testosterone - The King of All Steroids

Other Studies:

This is a list obtained from clinicaltrials.gov in summer of 2011 (visit the respective link to find out more about every study. This is a great way to not only have access to therapy, but also to have great monitoring and to serve for the better of humanity):

Title: Exogenous Testosterone plus Dutasteride for the Treatment of Castrate Metastatic Prostate Cancer
Recruitment: Recruiting
Conditions: Prostate Cancer|Castration-resistant, Metastatic Interventions: Other: testosterone (AndroGel®) with the 5α-reductase inhibitor dutasteride
URL: http://ClinicalTrials.gov/show/NCT00853697

Title: Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men
Recruitment: Recruiting
Conditions: Sarcopenia
Interventions: Drug: Testosterone injection|Drug: Testosterone gel
URL: http://ClinicalTrials.gov/show/NCT00957801

Title: Testosterone for Penile Rehab After Radical Prostatectomy
Recruitment: Recruiting
Conditions: Low Testosterone Levels|Erectile Dysfunction
Interventions: Drug: Testim® + Viagra®|Drug: Placebo Testim® + Viagra®
URL: http://ClinicalTrials.gov/show/NCT00848497

Title: Use of Nebido® to Assess Tolerability and Treatment Outcomes in Daily Clinical Practice
Recruitment: Recruiting Conditions: Male|Hypogonadism
Interventions: Drug: Testosterone Undecanoate (Nebido, BAY86-5037) URL: http://ClinicalTrials.gov/show/NCT00410306

Title: Pharmacokinetic and Comparative Bioavailability Study of Testosterone Absorption after Administration of Testosterone Gel 1.62% to the Upper Arms/Shoulders Using an Application Site Rotation or a Combination of Application Sites in Hypogonadal Males
Recruitment: Recruiting
Conditions: Hypogonadism
Interventions: Drug: Testosterone Gel 1.62%|Drug: Testosterone Gel 1.62%
URL: http://ClinicalTrials.gov/show/NCT01133548

Title: Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients with Hypogonadism
Recruitment: Not yet recruiting
Conditions: Type 2 Diabetes|Hypogonadism
Interventions: Drug: Testosterone
URL: http://ClinicalTrials.gov/show/NCT01084369

Title: An Open-Label Study of Serum Testosterone Levels in Non- dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier
Recruitment: Recruiting Conditions: Pharmacokinetics Interventions: Drug: Testosterone Gel 1.62%
URL: http://ClinicalTrials.gov/show/NCT01130298

Title: Testosterone Replacement for Fatigue in Male Hypogonadic Advanced Cancer Patients
Recruitment: Recruiting Conditions: Advanced Cancer
Interventions: Drug: Testosterone|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT00965341

Title: Effect of Testosterone in Men with Erectile Dysfunction
Recruitment: Recruiting
Conditions: Erectile Dysfunction|Testosterone Deficiency|Diabetes
Interventions: Drug: Sildenafil citrate (open label)|Drug: Testosterone gel 1% (active or placebo)|Drug: Topical testosterone gel 1%
URL: http://ClinicalTrials.gov/show/NCT00512707

Title: Influence of Administration Route of Testosterone on Male Fertility
Recruitment: Not yet recruiting
Conditions: Hypogonadism
Interventions: Drug: MPP10, testosterone|Drug: Testosterone
URL: http://ClinicalTrials.gov/show/NCT00705796

Title: NASOBOL spray in Hypogonadal Men in Comparison to Testosterone Levels in Normal Healthy Male Volunteers Recruitment: Recruiting
Conditions: Hypogonadism
Interventions: Drug: testosterone|Other: No treatment
URL: http://ClinicalTrials.gov/show/NCT00647868

Title: Effect of Testosterone Gel Replacement on Fat Mass in Males with Low Testosterone Levels and Diabetes
Recruitment: Not yet recruiting
Conditions: Hypogonadism|Diabetes
Interventions: Drug: Testosterone gel|Drug: placebo
URL: http://ClinicalTrials.gov/show/NCT00440440

Title: The Testosterone Trial
Recruitment: Recruiting
Conditions: Andropause
Interventions: Drug: AndroGel® (testosterone gel)
URL: http://ClinicalTrials.gov/show/NCT00799617

Title: Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients Recruitment: Recruiting
Conditions: Sexual Dysfunction, Physiological
Interventions: Drug: Testosterone Cream|Drug: Estring URL: http://ClinicalTrials.gov/show/NCT00698035

Title: Effect of Testosterone Therapy in Men with Alzheimer’s Disease and Low Testosterone
Recruitment: Recruiting
Conditions: Alzheimer’s Disease|Hypogonadism
Interventions: Drug: AndroGel (Solvay Pharmaceuticals)
URL: http://ClinicalTrials.gov/show/NCT00392912

Title: 5-Alpha Reductase and Anabolic Effects of Testosterone
Recruitment: Recruiting
Conditions: Male Hypogonadism|Muscle Atrophy|Prostate
Enlargement|Sarcopenia
Interventions: Drug: Testosterone Enanthate|Behavioral: Collection of 3-day food logs with counseling of subjects|Drug: Finasteride|Behavioral: Collection of 3-day food logs with counseling of subjects|Drug: Testosterone Enanthate|Drug: Finasteride|Behavioral: Collection of 3-day food logs with counseling of subjects
URL: http://ClinicalTrials.gov/show/NCT00475501

Title: Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception
Recruitment: Recruiting
Study Results: No Results Available
Conditions: Pain|Hypogonadism
Interventions: Drug: Androgel (testosterone gel)|Other: Placebo
URL: http://ClinicalTrials.gov/show/NCT00351819

Title: Testosterone Gel Applied to Women with Pituitary Gland Problems
Recruitment: Recruiting
Conditions: Panhypopituitarism
Interventions: Drug: Transdermal Testosterone gel
URL: http://ClinicalTrials.gov/show/NCT00144391

Title: Testosterone Therapy in Men With Low Testosterone Levels and Metabolic Syndrome or Early Stages of Type 2 Diabetes
Recruitment: Recruiting
Conditions: Metabolic Syndrome
Interventions: Drug: Transdermal testosterone therapy|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT00479609

Title: Effect of Testosterone Replacement on Insulin Resistance
Recruitment: Recruiting
Conditions: Metabolic Syndrome|Hypogonadism
Interventions: Radiation: Testosterone gel|Drug: Placebo for testosterone gel
URL: http://ClinicalTrials.gov/show/NCT00487734

Title: Effect of Androgel on Type 2 Diabetic Males with Hypogonadism
Recruitment: Recruiting
Conditions: Diabetes Mellitus Type 2
Interventions: Drug: Testosterone( AndroGel)
URL: http://ClinicalTrials.gov/show/NCT00350701

Title: TEAM: Testosterone Supplementation and Exercise in Elderly Men
Recruitment: Recruiting
Conditions: Healthy
Interventions: Drug: Testosterone Gel|Behavioral: Exercise – Progressive Resistance Training (PRT)|Drug: Placebo Gel URL: http://ClinicalTrials.gov/show/NCT00112151

Title: Dose Titration Investigation of the Pharmacokinetics of Testosterone Transdermal Systems in Hypogonadal Men Recruitment: Recruiting
Conditions: Hypogonadism
Interventions: Drug: Testerone Transdermal System
URL: http://ClinicalTrials.gov/show/NCT01104246

Title: Testosterone for Peripheral Vascular Disease
Recruitment: Recruiting
Conditions: Hypogonadism|Peripheral Vascular Disease|Type 2 Diabetes
Interventions: Drug: Testosterone|Drug: 0.9% saline
URL: http://ClinicalTrials.gov/show/NCT00504712

Title: A Pilot Study of Parenteral Testosterone and Oral Etoposide as Therapy for Men with Castration Resistant Prostate Cancer Recruitment: Recruiting
Conditions: Prostate Cancer
Interventions: Drug: Testosterone|Drug: Etoposide
URL: http://ClinicalTrials.gov/show/NCT01084759

Title: Efficacy and Tolerability of an Intra-Nasal Testosterone Product
Recruitment: Recruiting
Conditions: Hypogonadism
Interventions: Drug: Nasobol® (Itra-nasal Testosterone)|Drug: Androderm® (Positive Control)
URL: http://ClinicalTrials.gov/show/NCT00975650

Title: Testosterone Replacement in Men with Diabetes and Obesity
Recruitment: Recruiting
Conditions: Hypogonadism
Interventions: Drug: testosterone|Drug: placebo
URL: http://ClinicalTrials.gov/show/NCT01127659

Title: NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH)
Recruitment: Not yet recruiting
Conditions: Hypogonadism
Interventions: Drug: Testosterone Undeconate (Nebido, BAY86-
5037)|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT01092858

Title: Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism
Recruitment: Recruiting
Conditions: Panhypopituitarism
Interventions: Drug: Transdermal Testosterone Gel
URL: http://ClinicalTrials.gov/show/NCT00144404

Title: Effect of Increasing Testosterone on Insulin Sensitivity in Men with the Metabolic Syndrome
Recruitment: Recruiting Conditions: Metabolic Syndrome
Interventions: Drug: Zoladex|Drug: AndroGel|Drug: Arimidex
URL: http://ClinicalTrials.gov/show/NCT00438321

Title: Testosterone Replacement in Men with Non-Metastatic Castrate Resistant Prostate Cancer
Recruitment: Recruiting Conditions: Prostate Cancer
Interventions: Drug: AndroGel|Drug: placebo
URL: http://ClinicalTrials.gov/show/NCT00515112

Title: The Effect of IM Testosterone Undecanoate on Biochemical and Anthropometric Characteristics of Metabolic Syndrome in Hypogonadal Men
Recruitment: Recruiting
Conditions: Metabolic Syndrome|Hypogonadism
Interventions: Drug: Nebido (testosterone undecanoate)|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT00696748

Title: The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction
Recruiting Conditions: Hypogonadism|Erectile Dysfunction
Interventions: Drug: Testosterone undecanoate
URL: http://ClinicalTrials.gov/show/NCT00421460

Title: Transdermal Testosterone Gel/Effect on Erection Quality as Measured by DIR Recruitment: Recruiting Conditions: Hypogonadism
Interventions: Drug: AndroGel (Transdermal Testosterone Gel)
URL: http://ClinicalTrials.gov/show/NCT00425568

Title: The Effect of 5-Alpha Reductase on Testosterone in Men
Recruitment: Recruiting
Conditions: Sex Disorders
Interventions: Drug: testosterone enanthate|Drug: duastride
URL: http://ClinicalTrials.gov/show/NCT00070733

Title: Treatment of Erectile Dysfunction in Hypogonadal Men with Testosterone Undecanoate
Recruitment: Recruiting
Conditions: Erectile Dysfunction|Hypogonadotrophic Males
Interventions: Drug: Testosterone Undecanoate and/or PDE-5
URL: http://ClinicalTrials.gov/show/NCT00555087

Title: Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-Treated Chronic Pain Patients: A Pilot Study.
Recruitment: Recruiting
Conditions: Pain|Hypogonadism
Interventions: Drug: Testosterone Gel
URL: http://ClinicalTrials.gov/show/NCT00398034

Title: Anabolic Therapies: New Hope for Treating Secondary Disabilities of SCI
Recruitment: Recruiting
Conditions: Hypogonadism|Spinal Cord Injury
Interventions: Drug: Testosterone Replacement Therapy Patch 5mg daily
URL: http://ClinicalTrials.gov/show/NCT00266864

Title: Does Testosterone Improve Function in Hypogonadal Older Men
Recruitment: Recruiting Conditions: Hypogonadism Interventions: Drug: Testosterone
URL: http://ClinicalTrials.gov/show/NCT00304213

Title: The Effect of Testosterone Replacement on Bone Mineral Density in Boys and Men with Anorexia Nervosa
Recruitment: Recruiting
Conditions: Bone Metabolism
Interventions: Drug: testosterone cypionate|Other: Bone monitoring
URL: http://ClinicalTrials.gov/show/NCT00853502

Title: Effects of Testosterone in Women with Depression
Recruitment: Recruiting Conditions: Depression Interventions: Drug: Testosterone
URL: http://ClinicalTrials.gov/show/NCT00676676

Title: Reandron in Diabetic Men With Low Testosterone Level
Recruitment: Recruiting
Conditions: Type 2 Diabetes|Hypogonadism Interventions: Drug: Reandron 1000|Drug: placebo URL: http://ClinicalTrials.gov/show/NCT00613782

Title: Outcomes of Mechanically Ventilated Patients With Low Serum Testosterone
Recruitment: Recruiting
Study Results: No Results Available Conditions: Acute Respiratory Failure
Interventions:
URL: http://ClinicalTrials.gov/show/NCT00797433

Title: Testosterone Therapy on Angina Threshold and Atheroma in Patients with Chronic Stable Angina
Recruitment: Recruiting Conditions: Angina Pectoris
Interventions: Drug: Nebido
URL: http://ClinicalTrials.gov/show/NCT00131183

Title: Hormone and Information Processing Study
Recruitment: Recruiting Conditions: Mild Cognitive Impairment|Alzheimer’s Disease
Interventions: Drug: testosterone gel|Drug: placebo gel
URL: http://ClinicalTrials.gov/show/NCT00539305

Title: Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement
Recruitment: Recruiting Conditions: Hypogonadism
Interventions: Drug: dutasteride|Drug: placebo
URL: http://ClinicalTrials.gov/show/NCT00752869

Title: Testosterone Replacement in Middle-Aged Hypogonadal Men With Dysthymia: Parallel Group, Double Blind Randomized Trial
Recruitment: Recruiting Conditions: Dysthymic Disorder
Interventions: Drug: Testoviron
URL: http://ClinicalTrials.gov/show/NCT00260390

Title: Decreased Testosterone Levels in Men Over 65
Recruitment: Recruiting
Conditions: Aging|Hypogonadism|Andropause
Interventions: Drug: Anastrozole|Drug: Testosterone Gel|Drug: Placebo tablet|Drug: Placebo gel|Dietary Supplement: Calcium Cardone 500mg with vitamin D 400 IU
URL: http://ClinicalTrials.gov/show/NCT00104572

Title: Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
Recruitment: Recruiting
Study Results: No Results Available
Conditions: Kidney Failure|Kidney Diseases
Interventions: Drug: Testim (1% testosterone gel) URL: http://ClinicalTrials.gov/show/NCT00645658

Title: The Cardiac Benefit of Testosterone Replacement in Men with Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery
Recruitment: Recruiting
Conditions: Coronary Artery Disease
Interventions: Drug: AndroGel 5 Grams
URL: http://ClinicalTrials.gov/show/NCT00413244

Title: Dose-Response of Gonadal Steroids and Bone Turnover in Men
Recruitment: Recruiting
Conditions: Healthy Volunteers
Interventions: Drug: testosterone|Drug: goserelin acetate|Drug: anastrazole
URL: http://ClinicalTrials.gov/show/NCT00114114

Title: Effect of Androgel on Atherogenesis, Inflammation, Cardiovascular Risk Factors and Adiposity in Type 2 Diabetic Males With Hypogonadotrophic Hypogonadism
Recruitment: Not yet recruiting
Conditions: Type 2 Diabetic Male with Hypogonadotrophic Hypogonadism.
Interventions: Drug: Androgel
URL: http://ClinicalTrials.gov/show/NCT00467987

Title: Hormonal Factors in the Treatment of Anorexia Nervosa
Recruitment: Recruiting
Conditions: Anorexia Nervosa|Eating Disorder|Anxiety|Depression
Interventions: Drug: Testosterone|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT01121211

Title: Investigator Initiated Study of the Effects of Androgen Therapy on Carbohydrate and Lipid Metabolism In Elderly Men
Recruitment:
Recruiting Conditions: Aging|Obesity|Insulin Resistance|Hypogonadism
Interventions: Drug: Topical testosterone (Androgel) 10 g/day
URL: http://ClinicalTrials.gov/show/NCT00365794

Title: Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women Recruitment: Recruiting
Conditions: HIV Infections|Cachexia
Interventions: Drug: testosterone
URL: http://ClinicalTrials.gov/show/NCT00004400

Title: Amino Acid Supplement and/or Testosterone in Treating Cachexia in Patients With Advanced or Recurrent Cervical Cancer
Recruitment: Recruiting
Conditions: Cachexia|Cervical Cancer
Interventions: Dietary Supplement: leucine-enhanced essential amino acid dietary supplement|Drug: therapeutic testosterone|Other: placebo URL: http://ClinicalTrials.gov/show/NCT00878995

Title: Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease
Recruitment:
Recruiting Conditions: brca1 Mutation Carrier|brca2 Mutation Carrier|Breast Cancer
Interventions: Biological: therapeutic estradiol|Drug: deslorelin|Drug: therapeutic testosterone
URL: http://ClinicalTrials.gov/show/NCT00080756

Title: Effect of High Testosterone on Sleep-associated Slowing of Follicular Luteinizing Hormone (LH) Frequency in Polycystic Ovary Syndrome
Recruitment: Recruiting
Conditions: Polycystic Ovary Syndrome
Interventions: Drug: Flutamide|Drug: Placebo
URL: http://ClinicalTrials.gov/show/NCT00930228

Title: Metabolic Effects of Androgenicity in Aging Men and Women
Recruitment: Recruiting
Conditions: Aging|Insulin Resistance Interventions: Drug: Testosterone|Drug: Estrogen
URL: http://ClinicalTrials.gov/show/NCT00680797

Title: Safety and Efficacy of LibiGel® for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women
Recruitment: Recruiting
Conditions: Hypoactive Sexual Desire Disorder
Interventions: Drug: testosterone gel|Drug: placebo gel
URL: http://ClinicalTrials.gov/show/NCT00613002

Title: Sexual Dysfunction and Hypotestosteronemia In Patients With Obstructive Sleep Apnea Syndrome And Its Effects With CPAP Therapy
Recruitment: Recruiting
Conditions: Obstructive Sleep Apnea Syndrome (OSAS)|Sleep Apnea|Hypotestosteronemia
Interventions:
URL: http://ClinicalTrials.gov/show/NCT00832065

Title: Surveillance Study of Women Taking Intrinsa®
Recruitment: Recruiting
Study Results: No Results Available
Conditions: Ovariectomy|Hysterectomy|Hypoactive Sexual Desire Disorder
Interventions:
URL: http://ClinicalTrials.gov/show/NCT00551785

 


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