Androgen Receptors Downregulate Don’t They? Part 2

In part 1 of this article we discussed the mistake of thinking about androgen receptors (testosterone receptors) in the same way we think of other receptors such as beta-receptors. Beta-receptors down regulate in response to beta-adrenergic stimulation whereas there is good evidence that androgen receptors increase in numbers in response to androgens. We also discussed […]

Androgen Receptors Downregulate Don’t They? Part 1

There is as much misinformation about steroids as there is good information had among bodybuilding enthusiasts. Go to any gym and you will hear some kid spouting off to his buddies about how steroids do this, or how they do that, or whatever. This soon starts somewhat of a pissing contest (excuse the expression) as […]

The Thyroid Gland Part 2 – How to Renew its Activity During a Diet

Triacana - Triac - Tiratricol - TA3

The thyroid gland and the hormones that it produces are among the key factors which determine the success or failure of a diet. Because thyroid hormones are regulators of basal metabolism, they determine the daily consumption of calories. A strict diet downregulates the activity of the gland. This lowers the daily requirement in calories, obliging […]

The Thyroid Gland Part 1 – Fat Loss, Muscle Growth, and Diet

In this series I am going to write about the thyroid gland and the hormones that it produces (or that it no longer produces). Although the term “thyroid”‘ is often associated with fat loss, the thyroid also helps to gain or lose muscle. It therefore has other functions which will be described after we have […]

Nandrolone Positive Steroid Tests – What Do They Mean?

Deca Durabolin (Nandrolone Decanoate)

Drug testing using IOC standards is far from perfect. For more than two decades I have criticized the short sightedness of the IOC drug testing standard bearers. And much of what I said in that period of time has turned out to be right. Among many others, I criticized, right from the start, the flawed […]

What Do We Tell Teenagers About Anabolic Steroids?

Rick Collins, attorney at Collins, McDonald & Gann specializing in steroid law and dietary supplement law

Rick Collins’ Advice to Teenagers (excerpted from Legal Muscle) The way I see it, most everything has risks and benefits. That’s especially true of medications, such as anabolic steroids. The choice of whether or not to take steroids involves weighing the risks against the benefits. The risk include numerous possible side effects, including the possibility […]

What is GHRP-6 (Growth Hormone Releasing Hexapeptide)?

GHRP-6 is a peptide in the growth factor family.  It has strong effect on the release of Growth Hormone (GH).  Its main use is to promote food intake by stimulating hunger and aid in energy metabolism.   It can be used in the treatment of GH deficiency as well  as cachexia, eating disorders and obesity. Background […]

DNP, Fat Loss and Bodybuilding

DNP (2,4 dinitrophenol), bodybuilding and fat loss

DNP (2,4-Dinitrophenol), an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 10-12 pounds in 8 days of use. Classified as an “uncoupler of oxidative phosphorylation” medically, it is quite dangerous as […]

Anabolic Steroids and Aggression, Part 2: Does the Evidence Support a Causal Inference?

Findings regarding the AAS use and aggression relationship are inconsistent and vary with the nature of the study and design. Although widely accepted as fact, a review finds little, if any, strong evidence for a direct causal relationship. This may, in part, stem from confusion regarding the specific questions that are answerable by various research […]

Deeper Into Prostaglandin Use

PGF2, prostaglandins and muscle growth

Many readers enjoyed my previous article about prostaglandins as muscle builders. This short introduction to prostaglandins produced critics, controversies and queries. Prostaglandins, especially PGF2 are no wonder drugs. They will not make you a Mr. Olympia in a matter of days. They do not represent a substitute for training. Neither are they free of side-effects. […]