Hey All - Been having an issue with E2. I started trt about 3 years ago (age 43) test levels were in the 100's. After a few doc changes (not by my wish but insurance) my current doc seems to think that A-Dex is a good option for trt. My issue with this is - I have taken aromasin in the past and it worked great for a while - then after about 7 months it stopped working well for me. I also started to develop a small lump and had a sore breast. Old doc would not test for E2 but would Rx me whatever i wanted. Once I developed the pea i asked for letro and he gave it to me no problem. Letro not only killed the pea and gyro related issues it also killed sex drive. New doc says no to letro and wants me to use a-dex - don't have a problem with this - just want to manage E2. Which i did start taking. He had me taking 1mg on Monday - wednesday and friday. After taking it for a few weeks we did blood work and the levels came back as follows ESTRADIOL, FREE, LC/MS/MS Report Result Ref. Range Units Status Lab ESTRADIOL, FREE 0.63 pg/mL High Final EZ Reference Range: ADULTS: < OR = 0.45 ESTRADIOL 22 pg/mL Final EZ Reference Range: ADULTS: < OR = 29 He thinks that the current levels are good to go. My question is - i do not know how to read these results - is my main E2 22 or is it the free .63? If it is 22 then it seems i might be good to go and possibly stick with 1mg 3 days a week but i was thinking maybe i ought to try .5 3 days per week because at one point i think it got to low and had no morning wood. By the way I take 100mgs test cyp every 5 days. Results of Test levels testosterone, TOTAL, LC/MS/MS 569 250-1100 ng/dL Final SLI TESTOSTERONE, FREE 54.3 46.0-224.0 pg/mL Final SLI TESTOSTERONE,BIOAVAILABLE 111.6 110.0-575.0 ng/dL Final SLI SEX HORMONE BINDING GLOBULIN 50 10-50 nmol/L Final SLI ALBUMIN,SERUM 4.5 3.6-5.1 g/dL Final SLI NOTE FROM LAB FASTING:YES I have at my disposal - letro - a-dex - aromasin. I do find it harder to find the sweet spot with letro but it seems like the one AI that really helps me - just hate the sides with it (no sex drive). In 5 weeks i go for new bloods.