I'm asking this for the hub since he's busy doing other stuff but he'll read up later. He just went to the urologist's office today to pick up Testim and has started that, abandoning the Androgel (urologist says it has a better track record and our research indicates that's true, so it's worth trying.) The urologist will move on to injections quickly if this does not work. Interestingly, though, both the urologist and internist said, "But you're responding to the Androgel," as if he might not want to switch to Testim. Hello - an "improvement" from baseline 200 to a whopping 274 after three months on 10g per day Androgel? He can tell what clinical signs to notice for improvement and has not noticed any (maybe some increased muscle, and that's all.) So the first question is: Does it really matter if he applies it twice per day instead of once? (5 g. in the morning, 5. g. in the evening.) That's what he started doing with the Androgel a few weeks ago and would like to continue (Dr. was not in, and/or he forgot to ask this question last time.) We got the idea that there just might be a little more absorbed this way - 10 g. of goo is a lot to spread out in one application, too. Second question: Here's what a dr. friend of ours said - he is following this situation by correspondence and here's what he said in looking at a photo from just last weekend: "In deed he is not that fat, but you can see the signs of hypotestosteronism. I do not remember if his cortisol was checked or not? I think by the pic , testosterone need to be given injectable, and thyroid recheck along with cortisol." Now, what could he possibly mean - I asked and am waiting for a reply - but what could jump out of a photo to give such an impression? He's got sideburns so it's not like there's no facial hair (other facial hair shaved.) He's big and broad, fat belly that you can't see easily from the front, a sort of fat neck, that's all. A regular looking guy, the kind that would be a bouncer in a bar, the last one you'd pick out of a lineup to have any hormone problems, other than possibly the big gut, which as we all know, more than half the male population seems to sport, particular ex-football-player-looking guys. Anyone have any guesses? AND... when he goes to the internist on Monday, exactly what should he ask for in terms of further thyroid and particularly cortisol? Honestly, I hardly know what cortisol is or what tests are performed to evaluate it. His TSH was 4.2. Doesn't sound too good to me (I had the idea it should be around 1, under 2 in any case.) Any and all comments appreciated.