In his book : The edge effect, Dr. Eric Braverman says that by building up Serotonin not only will one get better sleep, but also Serotonin will help in replenishing Dopamine and Acetylcholine. Marianco, if you catch this post, would you be so kind as to let me know whether I'm correct with the following assumption ? Since Dr. Braverman doesn't provide any in-depth explanation of how Serotonin can help in replenishing Dopamine and Acetylcholine (aside from the better sleeping patterns part), I'll attempt from what I've learned from the many postings of Marianco to clear it up. First off, Marianco has recently posted and wrote many times in the past about SSRI's being helpful in adrenal fatigue by decreasing percieved stress. Serotonin can decrease the release of Norepinephrine from Norepinephrine neurons, in turn lowering the stress response (CRH>Norepi.>ACTH> Cortisol). Key in achieving success here appears to be in the dose--just the right dose, and the adrenals get proper rest, Norepinephrine output is decreased, and Dopamine gets a chance to replenish. However too high a Serotonin level, and it decreases Dopamine output from Dopamine releasing ( and IIRC production of DA toned down as well) neurons. In the above paragraph, I purposefully let Ach out of the picture, to concentrate on the replenishment of DA alone. Since I need to know how Serotonin can replenish Dopamine, I've attemtped to provide an explanation for it, through my readings of Marianco's postings. Marianco has made clear that dosage is key. This is often something that is not mentioned on various web based information. We often read that Serotonin will kill one's sex drive, but what I think is implied here, is that *excess* serotonin will kill it. Not much is said about low or inadequate serotonin levels though, and the increased perception of stress it brings about. To reiterate, what I'd like to know is how Serotonin (presumably in individuals vulnerable to stress) can replenish Dopamine. I think I'm pretty much correct with the above explanation, but I'd like for others to either confirm it, or bring out flaws in my attempted clearing up of it. Thanks in advance.