Clonidine /Excess Norephinephrine/ Adrenal Fatigue

Discussion in 'Men's Health Forum' started by gregxy, Dec 5, 2007.

  1. #1

    gregxy Junior Member


    I have been reading about Clonidine which is an older drug for treating hypertension.
    It works by triggering the alpha receptor in the CNS. This makes the brain think
    there is too much noreephinepherine and it responds by reducing sympathetic
    stimulus of the adrenal glands.

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    Excess norepi can cause many problems like high blood pressure, insomnia, anxiety.
    If too much dopamine is being converted to Norepi, then it may create libido problems
    as well.

    Clonidine is also reported to stimulate growth hormone release which is a plus.

    Anyone have any experience with it?
  2. #2

    jawbone Junior Member

    your overview of the drugs actions a re a bit over simplified. But this isnt a drug to mess around with. First, the sedation side is very real and long term use can have life threatening consequences if you suddenly stop taking it. as far as its GH effect--dont bother.
  3. #3

    gregxy Junior Member

    Thanks for the reply,

    No I would not recommend this clonidine to raise HGH. However I have high blood
    pressure, anxiety and trouble sleeping so I think that it might be a good fit for me.
    In addition the urine test that I took gave norepi as elevated and all other neurotransmitters
    as too low. I am going to see Dr Marianico on Monday to ask him about it.

    Many of the people on this forum report symptoms that sound to me like an overactive
    sympathetic nervous system. To me adrenal fatigue seems more like a result of
    too much sympathetic activity than the cause of it.

    There are several causes of excess sympathetic activity, the most common is mental
    stress. Marinico thinks that low thyroid is the another cause. A third cause could be
    underactivity of the alpha2 receptor in the CNS. This receptor provides negative
    feedback that controls norephinepherine levels. If the receptor is underactive, then
    norepi levels will be too high, the result is anxiety like symtoms.

    I suspect that there are genetic variations of all the receptors and enzymes in the body.
    Some versions are more or less active that the "norm". These variations are responsible
    for some of the variations in peoples personalities, how well they handle stress etc.
  4. #4

    jawbone Junior Member

    well if you had a 24 hr urine catch and your catacholamines are high, one has to see what the cause is not just cover the symptoms with a med like clonidine. First thing that comes to mind is a possible adrenal tumor. Good luck with your work up.
  5. #5

    JanSz Junior Member

    Ask your doc to do Genova Diagnostic testing.
    These tests:

    NutriEval (saliva, urine, blood)
    EstroEssence (first morning urine)

    possibly also

    Comprehensive Detoxification profile
    Also spend 2x $20 and study how to read and apply top two tests. - Online Professional Education
    NutrEval discussed
    EW04 - NUTRITIONAL EVALUATION: Understanding Your Patient's Supplement Needs
    A4M :: Conference Library
    A4M :: Conference Library
    Conference: A4M Las Vegas 2006
    Speaker: Patrick Hanaway, MD
    December 7, 2006 6:00 pm - 9:00 pm
    Estroessence discussed:

    GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
    Conference: A4M Orlando 2006
    Speaker: Patrick Hanaway MD
    Length: 31m 07s - 66 Slides
    April 9, 2006 5:00 pm - 5:40 pm
  6. #6

    gregxy Junior Member


    Mariano did the Sanesco saliva/urine test which gave Norepi as too high and DA and
    seritonin as too low. Although I don't know if the norepi is high enough to be an
    adrenal tumor. Mariano gave me cortisol which did help some but not enough.

    I have a bunch of what I call "anxiety related" symptoms:
    High BP, sweaty hands, IBS, difficulty sleeping, night sweats and heat intolerance.
    I can easily get erections but easily loose them if anything "bothers me".
    All of these will get worse if I am under stress. My thyroid is normal.
    My father also had high BP, glaucoma and was a nervous person, which makes me think
    that this is an inherited trait.

    I though it was interesting that the clonidine has been used to treat high BP, glaucoma,
    night sweats and IBS.

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