Estradiol does not Influence Lipid Measures and Inflammatory Markers

Discussion in 'Men's Health Forum' started by Michael Scally MD, Jul 3, 2018.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Estradiol does not Influence Lipid Measures and Inflammatory Markers in testosterone-Clamped Healthy Men

    Context - Experimentally controlled studies of estrogenic regulation of lipid measures and inflammatory cytokines in men are rare.

    Objective - To delineate the effect of estradiol (E2) on lipids and inflammatory markers.

    Study design - This was a placebo-controlled single-masked, prospectively randomized study comprising experimentally degarelix-downregulated healthy men (N=74, age 65, range 57-77 yr) assigned to 4 treatment groups:
    (1) i.m. saline, and oral placebo,
    (2) i.m. testosterone and oral placebo,
    (3) i.m. testosterone, oral anastrozole (aromatase inhibitor) and
    (4) i.m. testosterone, oral anastrozole and transdermal E2 for 22 (±1) days.

    Results - Mean mass spectrometry-quantified serum E2 concentrations ranged from 1.2 to 82 pg/mL in the 4 treatment groups. E2 extremes did not alter total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, nonHDL cholesterol, apolipoprotein B (Apo B), lipoprotein (a), interleukin-6 or hsCRP concentrations.

    Higher E2 concentrations elevated both SHBG and prolactin as positive controls.

    LDL cholesterol, adiponectin and leptin were higher in hypogonadal subjects without testosterone or estradiol addback (P=0.018, 0.039 and 0.023, respectively). Abdominal visceral fat area by CT (independent variable) correlated negatively with HDL cholesterol (P=0.017), and positively with triglycerides (P=0.004), hsCRP (P=0.005), and leptin (P<0.0001).

    Conclusion - In this placebo-controlled prospectively randomized study, wide variations in circulating E2 did not influence lipid measures and inflammatory markers when testosterone concentrations were controlled experimentally. However, medically induced central hypogonadism in older men was accompanied by increased LDL cholesterol and metabolic cytokines, adiponectin and leptin. Abdominal visceral fat correlated strongly and positively with triglycerides, hsCRP, and leptin, but negatively with HDL.

    Roelfsema F, Yang RJ, Veldhuis JD. Estradiol does not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men. Journal of the Endocrine Society 2018. Estradiol does not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men | Journal of the Endocrine Society | Oxford Academic