Full study needed please!

Discussion in 'Steroid Forum' started by heavyiron, Aug 13, 2013.

  1. heavyiron

    heavyiron Member

    I know one of you guys has this full study. I would be very appreciative to read it if someone could dig it up for me.

    Thanks!.

    Ann Intern Med. 1996 Dec 1;125(11):865-72.

    Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial.

    Waters D, Danska J, Hardy K, Koster F, Qualls C, Nickell D, Nightingale S, Gesundheit N, Watson D, Schade D.
    Source
    Department of Medicine/Endocrinology, University of New Mexico School of Medicine, Albuquerque 87131-5271, USA.

    Abstract
    OBJECTIVE:
    To increase lean body mass and improve health status in patients with wasting associated with the acquired immunodeficiency syndrome (AIDS) by treatment with recombinant human growth hormone (rhGH), recombinant human insulin-like growth factor 1 (rhIGF-1), or both.
    DESIGN:
    Randomized, double-blind, placebo-controlled clinical trial.
    SETTING:
    University of New Mexico Clinical Research Center and University of Texas Southwestern Medical Center.
    PATIENTS:
    60 patients with AIDS and wasting as defined by the Centers for Disease Control and Prevention. Patients were divided into four groups of 15 patients each.
    INTERVENTION:
    Group 1 received 1.4 mg of rhGH once daily plus placebo twice daily; group 2 received 5 mg of rhIGF-1 twice daily plus placebo once daily; group 3 received 5 mg of rhIGF-1 twice daily plus 1.4 mg of rhGH once daily; and group 4 received placebo three times daily.
    MEASUREMENTS:
    Body weight, body composition, muscle strength, protein catabolism, quality of life, and immune status were assessed at baseline, and changes in these variables were measured at 6 and 12 weeks.
    RESULTS:
    At 6 weeks, lean body mass had increased and total fat mass had decreased in the groups receiving rhGH, rhIGF-1, or both. Group 3 had the greatest changes in lean body mass (mean +/- SE, 3.2 +/- 0.59 kg; P < 0.001); only in this group were changes in body mass maintained at 12 weeks. Only patients in group 1 had improvement in muscular strength of the knees and upper body (P = 0.04) and quality of life (P = 0.01). Immunologic function did not improve in any group.
    CONCLUSIONS:
    Growth factor therapy had significantly increased lean body mass and decreased fat mass by 6 weeks, but these improvements persisted for 12 weeks only in group 3. Growth factor therapy at the dosages used in this study is not recommended because the magnitude of weight gain was modest and improvements in quality-of-life measures varied.
    Comment in
    Whither recombinant human growth hormone? [Ann Intern Med. 1996]
    PMID: 8967666 [PubMed - indexed for MEDLINE]
     
  2. The Dutchman

    The Dutchman Member

    You'll find the full text version in the attachment.
     

    Attached Files:

    Michael Scally MD and heavyiron like this.
  3. heavyiron

    heavyiron Member

    Thank you!
     
  4. The Dutchman

    The Dutchman Member

    You're welcome.
     
  5. Pericles

    Pericles Member

    Heavy:

    CONCLUSIONS:
    Growth factor therapy had significantly increased lean body mass and decreased fat mass by 6 weeks, but these improvements persisted for 12 weeks only in group 3. Growth factor therapy at the dosages used in this study is not recommended because the magnitude of weight gain was modest and improvements in quality-of-life measures varied.

    I can tell you that it is common for docs to write a script for growth. In fact a guy I know buys his growth from a guy w/ aids and a script. .
     
  6. heavyiron

    heavyiron Member

    I came across some very high end IGF-1lr3 and thought I would do a run of rHGH and igf-1 with testosterone. I have no problem getting the meds I just wanted to study this before doing my run.
     
  7. youngBuilder

    youngBuilder Member

    Interesting.

    How long do you plan on running it? What are the possible sides of a 6-12 week cycle of the rHGH and IGF-1?
     
  8. heavyiron

    heavyiron Member

    Not sure, I think I will go a few months if I don't get bored.

    I get a little water retention and my hands swell and tingle a bit but that's about it for sides.
     
  9. Pericles

    Pericles Member

    I am pretty ignorant about peptides. Will the above produce gains similar to real HGH?