Is 1000 IU 3x a week for HRT (Secondary hypogonadism) too much? I was prescribed 5000IU 3x a week. These are Japanese protocols. I am self-injecting so I can reduce the dose. My test levels went from below average range into the upper 1/3 range. E2 is 78 but unfortunately there are no protocols in place to reduce E2 as of yet in Japan.