HCG During A Cycle

Discussion in 'Steroid Forum' started by REK, Dec 13, 2011.

  1. REK

    REK Member

    hcg During A Cycle

    Saw this on another board and thought it was some great information to share.

    HCG – Unraveled
    Posted on October 11, 2009 by Eric Potratz

    Post-Cycle-Therapy is a must upon cessation of steroid use. Many great Post Cycle Therapy protocols have been outlined over the years, and many individuals have had success with following such protocols. Nevertheless, what works can always work better, and I intend to show you the most effective way to recover from AAS. This is especially the case for those that have had a lack of success following popular advice. In this article I will address the misunderstanding and misuse of Human Chorionic Gonadotropin (hCG) and show you the most efficient way to use hCG for the fastest and most complete recovery.

    HCG unraveled –

    Human Chorionic Gonadotropin (hCG) is a peptide hormone that mimics the action of luteinizing hormone (LH). LH is the hormone that stimulates the testes to increase testosterone levels. (1) More specifically LH is the primary signal sent from the pituitary to the testes, which stimulates the leydig cells within the testes to produce testosterone.

    When steroids are administered, LH levels rapidly decline. The absence of an LH signal from the pituitary causes the testes to stop producing testosterone, which causes rapid onset of testicular degeneration. The testicular degeneration begins with a reduction of leydig cell volume, and is then followed by rapid reductions in intra-testicular testosterone (ITT), peroxisomes, and Insulin-like factor 3 (INSL3) – All important bio-markers and factors for proper testicular function and testosterone production. (2-6,19) However, this degeneration can be prevented by a small maintenance dose of hCG ran throughout the cycle. Unfortunately, most steroid users have been engrained to believe that hCG should be used after a cycle, during Post-Cycle-Therapy. Upon reviewing the science and basic endocrinology you will see that a faster and more complete recovery is possible if hCG is ran during a cycle.

    Firstly, we must understand the clinical history of hCG to understand its purpose and its most efficient application. Many popular “steroid profiles” advocate using hCG at a dose of 2500-5000iu once or twice a week. These were the kind of dosages used in the historical (1960?s) hCG studies for hypogonadal men who had reduced testicular sensitivity due to prolonged LH deficiency. (21,22) A prolonged LH deficiency causes the testes to desensitize, requiring a higher hCG dose for ample stimulation. In men with normal LH levels and normal testicular sensitivity, the maximum increase of testosterone is seen from a dose of only 250iu, with minimal increases obtained from 500iu or even 5000iu. (2,11) (It appears the testes maximum secretion of testosterone is about 140% above their normal capacity.) (12-18) If you have allowed your testes to desensitize over the length of a typical steroid cycle, (8-16 weeks) then you would require a higher dose to elicit a response in an attempt to restore normal testicular size and function – but there is cost to this, and a high probability that you won’t regain full testicular function.

    One term that is critical to understand is testosterone secretion capacity which is synonymous to testicular sensitivity. This is the amount of testosterone your testes can produce from any given level of LH or hCG stimulation. Therefore, if you have reduced testosterone secretion capacity (reduced testicular sensitivity), it will take more LH or hCG stimulation to produce the same result as if you had normal testosterone secretion capacity. If you reduce your testosterone secretion capacity too much, then no amount of LH or hCG stimulation will trigger natural testosterone production – and this leads to permanently reduced testosterone production. (recovering full testosterone production is a topic for another article)

    To get an idea of how quickly you can reduce your testosterone secretion capacity from your average steroid cycle, consider this: LH levels are rapidly decreased by the 2nd day of steroid administration. (2,9,10) By shutting down the LH signal and allowing the testis to be non-functional over a 12-16 week period, leydig cell volume decreases 90%, ITT decreases 94%, INSL3 decreases 95%, while the capacity to secrete testosterone decreases as much as 98%. (2-6)

    Note: visually analyzing testes size is a poor method of judging your actual testicular function, since testicular size is not directly related to the ability to secrete testosterone. (4) This is because the leydig cells, which are the primary sites of testosterone secretion, only make up about 10% of the total testicular volume. Therefore, when the testes may only appear 5-10% smaller, the testes ability to secrete testosterone upon LH or hCG stimulation can actually be significantly reduced to 98% of their normal production. (3-5) So do not judge how “shutdown” you are by testicular size!

    The decreased testosterone secretion capacity caused by steroid use was well demonstrated in a study on power athletes who used steroids for 16 weeks, and were then administered 4500iu hCG post cycle. It was found that the steroid users were about 20 times less responsive to hCG, when compared to normal men who did not use steroids. (8) In other words, their testosterone secretion capacity was dramatically reduced because they did not receive an LH signal for 16 weeks. The testes essentially became desensitized and crippled. Case studies with steroid using patients show that aggressive long-term treatment with hCG at dosages as high as 10,000iu E3D for 12 weeks were unable to return full testicular size. (7) Another study with men using low dose steroids for 6 weeks showed unsuccessful return of Insulin-like factor-3 (INSL3) concentration in the testes upon 5000iu/wk of HCG treatment for 12 weeks (6) (INSL3 is an important biomarker for testosterone production potential and sperm production) 20

    In light of the above evidence, it becomes obvious that we must take preventative measures to avoid this testicular degeneration. We must protect our testicular sensitivity. Besides, with hCG being so readily available, and such a painless shot, it makes you wonder why anyone wouldn’t use it on cycle.

    Based on studies with normal men using steroids, 100iu HCG administered everyday was enough to preserve full testicular function and ITT levels, without causing desensitization typically associated with higher doses of hCG. (2) It is important that low-dose hCG is started before testicular sensitivity is reduced, which appears to rapidly manifest within the first 2-3 weeks of steroid use. Also, it’s important to discontinue the hCG before you start Post-Cycle-Therapy so your leydig cells are given a chance to re-sensitize to your body’s own LH production. (To help further enhance testicular sensitivity, the dietary supplement Toco-8 may be used)

    Based off the above information, an optimal dose of hCG during the cycle would be 250iu every 4 days, or as a less desirable alternative, once a week shot of 500iu. Keep in mind, that the half-life of hCG is 3-4 days, while the half-life of LH is only 1-2 hours. Considering this difference in excretion time, it is best to space each dose of hCG at least 4 days apart for the optimal “peak and valley” replication. However, going more than 7 days between each hCG shot may promote increase the rate of desensitization from lack of LH or hCG stimulation.

    If you are starting hCG late in the cycle, one could calculate a rough estimate for their required hCG “kick starting” dosage by multiplying 40iu x days of LH absence. (ie. 40iu x 60 days = 2400iu HCG dose) Remember, since the testes will be desensitized later in a cycle, you will require a higher dose. Also, the maximum daily dose of hCG should not exceed 5000iu, and 4-7 days must be taken off between each shot. Generally, a higher dose will require a longer off period between each shot. (eg., 2500iu = 7 days between each shot)

    Note: If following the on cycle hCG protocol, hCG should NOT be used for pct.

    Recap -

    For preservation of testicular sensitivity, use 250iu every 4 days starting 14 days after your first AAS dose. At the end of the cycle, drop the hCG two weeks before the AAS clear the system. For example, you would drop hCG about the same time as your last Testosterone Enanthate shot. Or, if you are ending the cycle with orals, you would drop the hCG about 10 days before your last oral dose. This will allow for a sudden and even clearance in hormone levels. This will initiate a strong LH and FSH surge from the pituitary, to begin stimulating your testes to produce testosterone. Remember, recovery doesn’t begin until you are off hCG since your body will not release its own LH until the hCG has cleared the system.

    In conclusion, we have learned that utilizing hCG during a steroid cycle will significantly prevent testicular degeneration. This helps create a seamless transition from “on cycle” to “off cycle” thus avoiding the post cycle crash.

    Now I would actually use 100iu hCG ED starting 3 days after your first AAS dose.

    A more convenient alternative to the above recommendation would be a weekly shot of 500iu hCG, throughout the entire cycle. Beyond this dose, one could calculate a rough estimate for their required hCG dosage by multiplying 40iu x days of LH absence. (40iu x 60 days = 2400iu HCG dose)

    The dose one needs varies and can be adjusted mid cycle if
    necessary. Because leptin is a major inhibitor of gonadal function
    in men, men with higher body fat levels require larger doses of HCG
    to get the same effect.

    Body Fat Percentage

    <10%: 250-300 iu twice weekly
    10-15%: 300-350 iu twice weekly
    >15%: 350-500 iu twice weekly

    5) Do the math to determine the volume you need for your desired
    dose. 1 cc = 1,000 iu, so 0.5 cc = 500 iu, 0.25 cc = 250 iu etc.

    6) Use an insulin syringe (29 gauge is ideal) to measure your dose
    and inject subcutaneously one inch to either side of your belly

    If testicular atrophy begins to occur on your selected dose, simply
    raise yourself to the next bracket. It is better to not use more
    than you need if you plan to come off cycle eventually. Minor
    atrophy is quickly reversed with proper Post Cycle Therapy.

    Cheers Rek
  2. bigrobbie

    bigrobbie Member AnabolicLab.com Supporter

    Nice info, and kudos for giving credit to the author of the post. Thanks for your honesty and for sharing!
  3. REK

    REK Member

    My pleasure bro.

  4. ultimate domination

    ultimate domination Junior Member

    i planned to start hcg week 3 but now i feel like i should start immediately or week 2. 250iu 2x/wk tho this made me consider 300iu 2x/wk because im closer to 15% than i am 10%

    what do you think?
  5. Bill Roberts

    Bill Roberts Steroid Forum Leader

    There's no reason to reduce the dose unless you are trying to stretch out your supply.

    There's no problem with starting sooner.

    On comparing same total IU usage staring a little bit sooner but at slightly lower dosage, I wouldn't know which might work better. I'd expect little if any difference in results.
  6. ultimate domination

    ultimate domination Junior Member

    thanks for the info man
  7. Bill Roberts

    Bill Roberts Steroid Forum Leader

    You're welcome!
  8. jp4355

    jp4355 Member

    Good Info, it's sometimes difficult to come by......................JP
  9. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    I will throw a wrench into the thread. There are a few valid points, but for the most part the OP sucks! Going further, Portratz is mo more than a scammer and fool.

    GMAFB! The recap should throw UP all sorts of alarm bells.
  10. ironborn34

    ironborn34 Member

    I always run hcg on cycle 250 iu 2x wk, it was embarrasing when id bring nnew women home when both my balls could fit in one 20 oz pepsi bottle cap. 2 wks and the difference was huge and they never shrunk again.
  11. Nitrust

    Nitrust Member

    Not to hijack your thread but can hcg be taken sublingually?
  12. Eloquence

    Eloquence Member

    Bump for knowledge
  13. Equinob

    Equinob Member

    Good read. I've been dosing 400iu EOD since week one. That was based on the idea I needed a minimum of 1,000iu/week. This would imply that based on body fat %, I need as little as 600-700iu/week. Curious about the every 4 day administration, as Bill Roberts speaks of Peaks and Valleys ... it would seem like a more constant state, say 200u EOD would provide more stable levels throughout the week, unless the half-life requires that 300-350 peak, every 4 days for some reason.
  14. crossfitisgay

    crossfitisgay Member AnabolicLab.com Supporter

    i just find pregnant women to pee in my mouth it tastes better
    Spooby, Buffhunter and Harmswhey like this.
  15. Ryno1980

    Ryno1980 Member

  16. Rickybrazil

    Rickybrazil Junior Member

    Does OTC sublingual hcg works?
  17. jp4355

    jp4355 Member

    You need to get Injectable HCG.
    It will come with a Vial of BA water to reconstitute it.................... JP
  18. Michael7

    Michael7 Member

    Nice info , thanks for sharing
  19. bygogo00

    bygogo00 Junior Member

    Profesional sir, get to know more...
  20. WyattEarp

    WyattEarp Member

    Can you elaborate? I’ve used it on cycle once. It stoped testicular atrophy etc. I have also read it can ruin a cycle, something to do with test absorption? What does your experience speak to sir?