I have high SHBG. My TT is borderline high and E2 borderline low. Pathology Thyroid Function TSH = 3.5 (0.5-3.8 mIU/L) FT4 = 18 (12-21 pmol/L) FT3 4.2 (4-6.8 pmol/L) prolactin 12 (4-15 ug/L) DHEAS 4 (0-14 umol/L) TT 27 (10-28 nmol/L) SHBG (86.7 (14.5-48.4 nmol/L) E2 53 (50-218 pmol/L) DHT - 2346 (860 - 3406 can't remember units) Cortisol 500 (170-540 nmol/L) My DHT used to above the top of the range and now, being in the middle of the range, seems to be partially contributing to my breast pain. In fact, since starting low dose (about 2mg) Andractim (DHT cream) my pain has decreased significatly. (I'm super-sensitive to meds, hence the micro doses). Last year when I used low dose danazol (2.5mg - 5mg per day), it made me feel better at first before it lowered my E2 and DHT too much and I caused me breast pain. Any idea how to increase E2 slightly so that I can take danaozl to lower my SHBG.