Insulin-like Growth Factor-1 Deficiency

Discussion in 'Human Growth Hormone and Peptides' started by Michael Scally MD, Oct 1, 2019.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Ittoop T, Reddy SSK. Insulin-like Growth Factor-1 Deficiency. In: McDermott MT, ed. Management of Patients with Pseudo-Endocrine Disorders: A Case-Based Pocket Guide. Cham: Springer International Publishing; 2019:235-49. Insulin-like Growth Factor-1 Deficiency

    Since insulin-like growth factor-1 (igf-1) measurement has become widely known to reflect cumulative growth hormone (GH) secretion, it is not surprising for clinicians to be tempted to use IGF-1 levels to not only screen for GH excess but for GH deficiency also (Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med. 1997;336:633–40).

    Can low IGF-1 levels be used as a surrogate indicator of reduced GH secretion?
    Are low IGF-1 levels prognostic of other pathologies?

    To interpret IGF-1 levels properly, it is important to understand IGF-1/GH regulation and related variables.

    The causes of IGF-1 deficiency can be classified into two main types: primary and secondary.
    Primary IGF-1 deficiency refers to IGF-1 impairment but with normal GH secretion.
    Secondary IGF-1 deficiency refers to IGF-1 impairment due to some dysregulation in GH secretion.

    Low IGF-1 levels without no GH related issues, may be a prognostic indicator of one of the individual’s co-morbidities.