IV (Intravenous) HGH administration? Vs. IM/sub Q.

Mayne

Member
Maybe it will be better but will it be noticeable? I am unaware as I haven't done it myself yet. But I agree even if it is a minimal difference better choose the optimal
 

LeoTC

Member
Google just gives a shitload of search results that are unrelated. It seems like that’s all you get anymore, and you have to scroll through 10 pages of bullshit to find anything related to what you actually want to see.

Bing is better.
 

stone988

Member
Wow, one of the articles you posted (Regulation of muscle mass by growth hormone and IGF-I) which is all medical study, claims there is no muscle mass benefit/increase for healthy adults, with supraphysiological levels of HGH/IGF1. And they administered HGH and/or IGF-1 for periods up to 6 months, with no recorded effect on muscle mass growth. They even stated that in cases of acromegaly, it could be argued that, high levels of GH and IGF are detrimental to strength and muscle mass.

I find all of that very hard to believe.. Using HGH wouldn’t be so effective in bodybuilding if it had no effect on lean mass. I think these studies need to be revisited, and approached in a different manner.
Very true one must use testosterone to get any muscle building effects. IMO a dose that converts to a decent amount of estrogen as well.
 

Whoremoans

Member
I want to note something, based on this chart @Mayne posted. Looking at the dosages, for IM and subQ they used 0.1mg/kg. So lets assume the test subjects were average sized males, around 175-180lbs or roughly 80kg. That would equal 8mg (24iu) of HGH administered for IM and subQ, both resulting in a peak of about 60ng/mL.
For IV they only administered .02mg per kg. So assuming the same 80kg, that would equal only 1.6mg (4.8iu) HGH, which resulted in a peak of about 400ng/mL.

24iu HGH IM/subQ = peak of 60ng/mL
4.8iu HGH IV = peak of 400ng/mL

That’s an insane difference in plasma concentration, especially considering the doses.
But the IV admin rapidly dissipated, and was basically gone after 2 hours, where the other ROAs lasted 16 hours, and beyond, staying far more stable.
CADC72EE-EC15-420D-9FF3-F663CA200169.jpeg
 

Whoremoans

Member
Based on this information though, I’m still not sure which would be most effective for overall muscle growth, considering subQ results in the highest IGF conversion. I know HGH has muscle building “properties” other than its conversion to IGF, but isn’t that typically viewed as the primary means? There’s really always so much more to learn. Lol. Thank you for the useful info, again @Mayne

27A38438-9D05-4C45-811A-4581715C70BD.jpeg
 

Delt123

Member
Following. Will never put that in my veins tho. For all I knew, GH doesn't build muscle. I dont have a strong opnion on it either because it's clearly doing something. I have the idea that it's like 1+1=3 : being steroids + GH.
 

Whoremoans

Member
Following. Will never put that in my veins tho. For all I knew, GH doesn't build muscle. I dont have a strong opnion on it either because it's clearly doing something. I have the idea that it's like 1+1=3 : being steroids + GH.
I’ve always thought of it the same way, and explained it exactly as you just did, the 1+1=3 concept because of their synergistic nature, but I never would’ve guessed HGH alone had no muscle building benefit.
 

biggerben69

Member
I’ve always thought of it the same way, and explained it exactly as you just did, the 1+1=3 concept because of their synergistic nature, but I never would’ve guessed HGH alone had no muscle building benefit.
Hope you're doing well, Whoremoans?
Over at the iron den there are a couple of guys that run gh by way of IV. Think Sponge is one of the guys I remember discussing it?
Sponge is also at undergroundbodybuilding and does what mac11wildcat does here on both those boards and has for been at it since at least 2010 when the Den went online.
He was clear, that in his opinion, IV was the most effective ROA. Most effective in regards to what, exactly, I don't recall?
What stuck in my head from one of his posts many years ago is a little confusing based on your post that you took from what at a glance looked likema clinical trial of some kind?
Your posted how IV has the fastest clearance of gh.
Sponge said the goal was to keep something circulating in the blood as long as possible.

I'm thinking that though IV clears the fastest, because the gh is directly inj into the bloodstream, something in the gh will remain longer than when it is inj IM or Subc that has the gh make its way to the bloodstream after inj?
I could also not be remembering correctly?
Mands still spends a decent amount of time there so you might ask him?
Also, Wm, you know I've only used Serostim and have since 2005. If I was to ever run gh it would only be with US Pharm gh. I'd be concerned about contamination with generics. Take care.
 

Mayne

Member
Hope you're doing well, Whoremoans?
Over at the iron den there are a couple of guys that run gh by way of IV. Think Sponge is one of the guys I remember discussing it?
Sponge is also at undergroundbodybuilding and does what mac11wildcat does here on both those boards and has for been at it since at least 2010 when the Den went online.
He was clear, that in his opinion, IV was the most effective ROA. Most effective in regards to what, exactly, I don't recall?
What stuck in my head from one of his posts many years ago is a little confusing based on your post that you took from what at a glance looked likema clinical trial of some kind?
Your posted how IV has the fastest clearance of gh.
Sponge said the goal was to keep something circulating in the blood as long as possible.

I'm thinking that though IV clears the fastest, because the gh is directly inj into the bloodstream, something in the gh will remain longer than when it is inj IM or Subc that has the gh make its way to the bloodstream after inj?
I could also not be remembering correctly?
Mands still spends a decent amount of time there so you might ask him?
Also, Wm, you know I've only used Serostim and have since 2005. If I was to ever run gh it would only be with US Pharm gh. I'd be concerned about contamination with generics. Take care.
Pardon me but if people inject h and what not IV why would you be worried about underground rhGH which I think would have a better chance at being checked for quality and safety in a way
 

biggerben69

Member
Pardon me but if people inject h and what not IV why would you be worried about underground rhGH which I think would have a better chance at being checked for quality and safety in a way
I don't and never have slammed street drugs. However, with smack don't throw some heat at the spoon and then filter into your rig?
Heat would destroy the delicate gh so you'll mix and then bang?
We do know the fda isn't supervising whats going down in the Schezwyan Province so who knows how the powder is handled?
I quoted Wh but you're certainly welcome to engage. You doing ok, Mayne? We have some unfiinished businessess I've forgotten about?
 

Mayne

Member
I don't and never have slammed street drugs. However, with smack don't throw some heat at the spoon and then filter into your rig?
Heat would destroy the delicate gh so you'll mix and then bang?
We do know the fda isn't supervising whats going down in the Schezwyan Province so who knows how the powder is handled?
I quoted Wh but you're certainly welcome to engage. You doing ok, Mayne? We have some unfiinished businessess I've forgotten about?
That heat point I didn't actually think about. I wonder how much difference is there from injecting IM and IV if both ways the rhGH will find it's way into the blood stream. I am all okay ben and nope none that I have in mind
 

biggerben69

Member
Pardon me but if people inject h and what not IV why would you be worried about underground rhGH which I think would have a better chance at being checked for quality and safety in a way
Are you implying that you and others here are active IV heroin users and are interested in not wasting any space left in your rig and figure, gh, why not?
I don't have any real issue with any of that. I just didn't know it was that kind of party.
Whoremoans knows me. I'd expect an invite based on him knowing that, even though i might not join in, I'd for sure show up and the gift I'd bring would be worth the price of admission for anyone else that happens to show up.
Isnt that right, @Whoremoans?
 

biggerben69

Member
I don't and never have slammed street drugs. However, with smack don't you throw some heat at the spoon and then filter into your rig?
Heat would destroy the delicate gh so you'll mix and then bang?
We do know the fda isn't supervising whats going down in the Schezwyan Province so who knows how the powder is handled?
I quoted Wh but you're certainly welcome to engage. You doing ok, Mayne? We have some unfiinished businessess I've forgotten about?
 

biggerben69

Member
I don't and never have slammed street drugs. However, with smack don't you throw some heat at the spoon and then filter into your rig?
Heat would destroy the delicate gh so you'll mix and then bang?
We do know the fda isn't supervising whats going down in the Schezwyan Province so who knows how the powder is handled?
I quoted Wh but you're certainly welcome to engage. You doing ok, Mayne? We have some unfiinished businessess I've forgotten about?
 

Mayne

Member
Are you implying that you and others here are active IV heroin users and are interested in not wasting any space left in your rig and figure, gh, why not?
I don't have any real issue with any of that. I just didn't know it was that kind of party.
Whoremoans knows me. I'd expect an invite based on him knowing that, even though i might not join in, I'd for sure show up and the gift I'd bring would be worth the price of admission for anyone else that happens to show up.
Isnt that right, @Whoremoans?
I haven't injected anything IV, my question was purely based on curiosity with the example made to reinforce the idea and understand better the harm reduction part of injecting rhGH through IV approach instead of IM/subq if we find enough information to demonstrate the benefit
 

Whoremoans

Member
Hope you're doing well, Whoremoans?
Over at the iron den there are a couple of guys that run gh by way of IV. Think Sponge is one of the guys I remember discussing it?
Sponge is also at undergroundbodybuilding and does what mac11wildcat does here on both those boards and has for been at it since at least 2010 when the Den went online.
He was clear, that in his opinion, IV was the most effective ROA. Most effective in regards to what, exactly, I don't recall?
What stuck in my head from one of his posts many years ago is a little confusing based on your post that you took from what at a glance looked likema clinical trial of some kind?
Your posted how IV has the fastest clearance of gh.
Sponge said the goal was to keep something circulating in the blood as long as possible.

I'm thinking that though IV clears the fastest, because the gh is directly inj into the bloodstream, something in the gh will remain longer than when it is inj IM or Subc that has the gh make its way to the bloodstream after inj?
I could also not be remembering correctly?
Mands still spends a decent amount of time there so you might ask him?
Also, Wm, you know I've only used Serostim and have since 2005. If I was to ever run gh it would only be with US Pharm gh. I'd be concerned about contamination with generics. Take care.
I’d say there is a tad more risk with IVing generics, but assuming quality control is up to par, I wouldn’t worry too much, personally. I’ve risked far more dangerous things in the past lol. Serostim or other pharm grade would definitely be the way to go though if available.
 

jJjburton

Member
AnabolicLab.com Supporter
Yea the track marks alone would not be good. Since to keep levels elevated you would have to be pinning a bunch each day.
 

Mayne

Member
A tiny update from me, I have decided on a change from subq to IM and noticed within basically a day numbness in the fingers which I usually experience extremely rarely but it is now nearly daily. I have been reading more on the subject and I believe Bill Roberts pointed out increased chance to be affected by side effects when doing IM. Also he mentioned that bioavailability with both subq and IM is nearly at 100%. I wonder which information to believe because then on elitefts there is a post which mentioned subq being at 75% and IM at 63%. Either way information I have found interesting is that injecting IM will benefit better because of the higher amount of blood vessels and it being nearly equal to IV which I believe is what dat also had in mind.
 

Tiredandhot

Member
A tiny update from me, I have decided on a change from subq to IM and noticed within basically a day numbness in the fingers which I usually experience extremely rarely but it is now nearly daily. I have been reading more on the subject and I believe Bill Roberts pointed out increased chance to be affected by side effects when doing IM. Also he mentioned that bioavailability with both subq and IM is nearly at 100%. I wonder which information to believe because then on elitefts there is a post which mentioned subq being at 75% and IM at 63%. Either way information I have found interesting is that injecting IM will benefit better because of the higher amount of blood vessels and it being nearly equal to IV which I believe is what dat also had in mind.
I'd trust Robert's over Elitefitness, that's for sure. Believe IM just causes faster absorption over SC.
 

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