Metformin seems to be an amazing drug for purposes of increasing insulin sensitivity but it is clearly documented that it inhibits igf-1 release. I can't make heads or tails of the exactly how significant this is based on the studies I am reading. Does it inhibit IGF-1 release by 100%, like no IGF1 is being released? Is it a small margin? Will HGH mitigate it? Since I know we have some smart guys on meso, even a few doctors, I thought I would ask this over here. I asked on other forums and didn't really get any insight.