Muscle AR Content Not Hormones is Associated with Hypertrophy

Discussion in 'Steroid Forum' started by Michael Scally MD, Sep 15, 2018.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Muscle Androgen Receptor Content but Not Systemic Hormones is Associated with Resistance Training-Induced Skeletal Muscle Hypertrophy

    The factors that underpin heterogeneity in muscle hypertrophy following resistance exercise training (RET) remain largely unknown. We examined circulating hormones, intramuscular hormones, and intramuscular hormone-related variables in resistance-trained men before and after 12 wk of RET.

    Backwards elimination and principal component regression evaluated the statistical significance of proposed circulating anabolic hormones (e.g., testosterone, free testosterone, dehydroepiandrosterone, dihydrotestosterone, insulin-like growth factor-1, free insulin-like growth factor-1, luteinizing hormone, and growth hormone) and RET-induced changes in muscle mass (n=49).

    Immunoblots and immunoassays were used to evaluate intramuscular free testosterone levels, dihydrotestosterone levels, 5a-reductase expression, and androgen receptor content in the highest- (HIR; n=10) and lowest- (LOR; n=10) responders to the 12 wk of RET.

    No hormone measured before exercise, after exercise, pre-intervention, or post-intervention was consistently significant or consistently selected in the final model for the change in: type 1 cross sectional area (CSA), type 2 CSA, or fat- and bone-free mass (LBM). Principal component analysis did not result in large dimension reduction and principal component regression was no more effective than unadjusted regression analyses.

    No hormone measured in the blood or muscle was different between HIR and LOR. The steroidogenic enzyme 5a-reductase increased following RET in the HIR (P<0.01) but not the LOR (P=0.32). Androgen receptor content was unchanged with RET but was higher at all times in HIR.

    Unlike intramuscular free testosterone, dihydrotestosterone, or 5a-reductase, there was a linear relationship between androgen receptor content and change in LBM (P<0.01), type 1 CSA (P<0.05), and type 2 CSA (P<0.01) both pre- and post-intervention.

    These results indicate that intramuscular androgen receptor content, but neither circulating nor intramuscular hormones (or the enzymes regulating their intramuscular production), influence skeletal muscle hypertrophy following RET in previously trained men.

    Morton RW, Sato K, Gallaugher MP, et al. Muscle Androgen Receptor Content but Not Systemic Hormones is Associated with Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men. Front. Physiol. Muscle Androgen Receptor Content but Not Systemic Hormones is Associated with Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men
     
    DrankSlangin and Millard Baker like this.
  2. 350lift

    350lift Member

    Well yeah because the hormones don’t do shit if they don’t bind to the receptor and activate them so they can carry out effects