My Blood Test Results On Testosterone base In DMSO

Discussion in 'Steroid Forum' started by Goingstronger, Dec 4, 2019 at 4:37 PM.

  1. Goingstronger

    Goingstronger Member

    As some of you know already, I'm applying a solution of test base powder in 100% pure DMSO on my scrotum twice a day, for a total of roughly 75mg testosterone a day.

    I went ahead and did a blood test as I was curious to know how much test would be left in my blood 10h after applying it on my scrotum.
    I'm absolutely baffled at the results:
    Total test: 2492ng/dl (240-870)
    DHT: 427ng/dl (33-120)
    E2: 36pg/ml (11-44)

    They didn't test for free T although it was written on the script.

    My main experiment goal was to know whether much of the test would be in my blood 10h after application as it's not attached to an ester, and was expecting the value to be low.
    I'm just amazed
     
  2. johntt44

    johntt44 Member

    That's pretty high!
     
  3. SteroidsBro

    SteroidsBro Member

    How can e2 be that low?

    Why on the sack? Why not just a leg?
     
  4. Goingstronger

    Goingstronger Member

    That was after only two days worth of application and a 30 days wash of period off of everything.
    The t hadn't had time to fully aromatize yet, just like the DHT wasn't sky high yet as it should be with scrotal test application
     
  5. Grab Bag

    Grab Bag Member

    Holy shit dude.

    have you ever done the same experiment with an esterized test? REALLY looking forward to seeing follow up bloods in the future as far as what happens with estrogen, dht, and other related values. Also very keen to hear how your scrotum skin holds up, I hope that you don’t have any issues.
    Very interesting stuff!
     
  6. SteroidsBro

    SteroidsBro Member

    How can test be so high even if your scrotum absorbed 100% of the 150mg of test?
     
  7. Iron Frenchie

    Iron Frenchie Member

    Definitely something up with the half life. Maybe at 10h it’s peaked out.
     
  8. Goingstronger

    Goingstronger Member

    Not 150mg, it's 75mg total testosterone a day.
    How is it NOT possible is the question, with 100% absorption: 75mg/day = 525mg/week.

    Are those levels unheard of for someone on 500mg/week?
     
  9. Weights

    Weights Member

    Pharmaceutical test cream recommends putting it on your shoulders or stomach. Why did you choose your scrotum?
     
    Rosconow likes this.
  10. SteroidsBro

    SteroidsBro Member

    Oh ya. That's crazy the scrotum absorbs so much.
     
  11. proken

    proken Member

    Any hair loss on your ball sack? Did you measure your testicle size pre-dosing? I'm just trying to be humorous but I am very interested in the absorption. This is a very cool experiment. How did you think of it?
     
  12. Goingstronger

    Goingstronger Member

    Higher absorption.
    Higher DHT conversion.
     
    OnTheRize likes this.
  13. Old

    Old Member

    Guess the question now is, what would it be if you injected 75mg TNE and measured 10 hours later? That would help establish absorption amount - though it appears that you are getting a large amount in this way.

    Case Study: Absorption of Testosterone Cream via Scrotal Delivery. - PubMed - NCBI

    "Transdermal testosterone has been used for years to treat patients with low testosterone symptoms. Clinically, we have monitored patients to evaluate results of testosterone absorption via blood serum concentrations. The data on multiple time points to determine trough and peak concentrations is lacking in the literature. In this case study, we demonstrate the absorption of testosterone cream via scrotal delivery. The data suggests that after application therapeutic levels are reached with concentrations of (1204.7 ng/dL) within two hours. Additionally, consistent concentrations (1320.6 ng/dL) remain beyond six hours. To our knowledge, this is the first study to collect and measure multiple time points for testosterone via transdermal delivery. The research indicates that testosterone via transdermal delivery is an excellent method to achieve therapeutic concentrations of testosterone. Most importantly, the patient's symptoms resolved without side effects."​


    androgel absorbs over many hours. [ Don't know about your DSMO mix ] One is not supposed to swim or bath for 5 hours after application. AndroGel (Testosterone Gel for Topical Use): Side Effects, Interactions, Warning, Dosage & Uses

    "AndroGel 1% is a hydroalcoholic formulation that dries quickly when applied to the skin surface. The skin serves as areservoir for the sustained release of testosterone into the systemic circulation. Approximately 10% of the testosterone dose applied on the skin surface from AndroGel is absorbed into systemic circulation. In a study with AndroGel 1% 100 mg , all patients showed an increase in serum testosterone within 30 minutes, and eight of nine patients had a serum testosterone concentration within normal range by 4 hours after the initial application. Absorption of testosterone into the blood continues for the entire 24-hour dosing interval. Serum concentrations approximate the steady-state concentration by the end of the first 24 hours and are at steady state by the second or third day of dosing."​

    Perhaps the low (10%) absorption of AndroGel matches IM application if this link is true. TESTOSTERONE CREAM | Compounding Pharmacy - Empower Pharmacy

    "About 90% of an intramuscular testosterone dose is excreted in the urine as conjugates of glucuronic and sulfuric acids."​
     
  14. OnTheRize

    OnTheRize Member

    DMSO (dimethyl sulfoxide) is a solvent that has been used for many many years in chemistry. It had a short period of widespread medical use in the 80' where it was touted as a cure all for musculoskeletal injuries by a few select doctors. It fell out of favor with the medical field...though I can't remember why.

    DMSO has a the unique property of being able to rapidly pass other substances mixed with it into the skin...however, it imparts a nasty garlicky, rotten cabbage, and oyster like taste in the mouth and lungs when it is applied to the skin. I believe that this is one of the reasons DMSO is not used as a carrier to make other oral or IM only drugs available transdermally. I believe that biggest reason DMSO is not used as a carrier in common medicine is because it is such an efficient agent at transporting EVERYTHING through the skin membrane that it is nonselective of what other agents cross through the skin into the bloodstream...this is problematic if the skin is not completely clean and absent of any other substances aside from the agent which is desired to enter the blood stream. The skin is a protective barrier on the body which serves, in part, to keep a large degree of undesired chemicals out of the bloodstream. In other words, you would not want ANYTHING on the DMSO application site which you are not willing to inject...this includes soap residue, substances with traces of heavy metals or chemical impurities, traces of lotion or skin care products, ANYTHING at all which you do not want transported into your blood stream. DMSO is that efficient at delivering outside substances inside your body.
    When I was younger...and much more stupid...my friends and I used to put cocaine and DMSO on our wrists and rub it in. The effect produced by the cocaine was almost immediate. It was so quick and efficient at absorbing the drug into our system that it was very similar to IV'ing the drug. THAT IS HOW EFFICIENT DMSO IS and I believe it's ability to transfer ALL chemicals, desired or otherwise, through the skin so rapidly and efficiently might be a major contributing factor as to why we don't hear about DMSO more.
    DMSO is, as far as I know, not known to cause any medical problems applied by itself. I wouldn't baptize a baby in the stuff but from what I remember, it's harmless by itself.

    @Old The PubMed study is spot on with the scrotal cream. I would say that the compounding pharmacy "empower" isn't a reliable source of information since it is a company with monetary motives driving what it publishes and they compound a hydroalcoholic T-gel equivalent to Androgel...Androgel is riddled with problems as a TRT product and absorbs differently on different skin types and under different conditions such as humid/cold weather. Androgel is transferrable to other people for up to 6 hours after application...Androgel...is...crap.
     
    Goingstronger and Old like this.
  15. Weights

    Weights Member

    Why do you want higher dht? You can get prostate issues from that
     
  16. OnTheRize

    OnTheRize Member

    The only benefits I can think of is that higher DHT is known to lower SHBG and unbind testosterone allowing it to be more bioavailable and, from what I understand, DHT is a component of libido that may be beneficial for someone who doesn't easily convert test through the 5-ar pathway...for many, very high DHT can be problematic but for others it might be desirable.

    I personally don't want my DHT levels any higher since my body hair increases on test cycles alone anyway.



    All transdermal scrotal applications of Testosterone (including the scrotal creams and scrotal patches) lead to higher elevations in DHT than do IM injections of test.
     
  17. Goingstronger

    Goingstronger Member

    DHT heavily opposes estrogen action.
    DHT has never been the identified culprit in prostate issues. However, high testosterone in the absence of high DHT has
     
    johntt44 likes this.
  18. OnTheRize

    OnTheRize Member

    Interesting...didn't know this and am definitely not going to argue it but are there any studies to support the idea that DHT doesn't promote BPH and LUTS? I'd like to research it.
    It's particularly interesting because doctors still prescribe 5-ARI's as the first line of defense to treat BPH. Why would finasteride and dutasteride still be prescribed to men with BPH? These medications are also thought to aid in reducing present prostate cancers by one third via reducing the amount of DHT present in the bloodstream by about 25-55%

    What are your thoughts?
     
  19. Old

    Old Member

    Never worked with DMSO. The main thing I remember was it was popular in the 70s and 80s for 'detoxing'. It will attach to a lot of stuff but of course, the usual problem of 'detoxing' where one loosens toxins but the body simply can't remove it that fast (that is why they accumulated in the first place). So people get headaches, fatigue, general malaise, and worse.
    Still, your account of 'needleless mainlining' is rather amusing.

    Doctors do this because they are decades behind. Google: estrogen prostate pubmed and you should find that E is the main problem with cancer and these studies go back 3 decades. Oddly, my Urologist mentioned this last year. But until medical instructions are altered, doctors must treat this way.

    As for 5-ARI's, they do reduce prostate size and PSA but actually hide cancers until they are aggressive and far more dangerous. [ There are threads on this forum both regarding finasteride and the prostate ]

    There is even a study showing that SHBG causes prostate problems when elevated through direct action (not its binding to hormones). Curiously, high SHBG will reduce DHT the most, then T some, then E2 a little bit so that the most active hormones shift toward E2.