nuclear receptor insensitivity (GC)

zkt

Member
[ame=http://en.wikipedia.org/wiki/Theophylline]Theophylline - Wikipedia, the free encyclopedia[/ame]

You might not be to far off to generalize this to sex steroid hormones IMHO.

It has been shown that theophylline may reverse the clinical observations of steroid insensitivity in patients with COPD and asthmatics that are active smokers (a condition resulting in oxidative stress) via a distinctly separate mechanism. Theophylline in vitro can restore the reduced HDAC (histone deacetylase) activity that is induced by oxidative stress (i.e., in smokers), returning steroid responsiveness toward normal.
 

Mr. Joe

Member
The idea is nice, but technically this isn't inhibition of corticosteroid receptor desensitization. This is simply synergy between theophylline and corticosteroid-induced HDAC activity. It would only be of use if the androgen receptor similarly induced HDAC activity targeted toward catabolic genes.

HDACs turn off gene expression, so you could speculate that theophylline supplementation could even counteract supplementation with AAS.

In theory though, there are probably several compounds which augment second messengers of the AR which could be beneficial.

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
 

zkt

Member
The idea is nice, but technically this isn't inhibition of corticosteroid receptor desensitization. This is simply synergy between theophylline and corticosteroid-induced HDAC activity. It would only be of use if the androgen receptor similarly induced HDAC activity targeted toward catabolic genes.

HDACs turn off gene expression, so you could speculate that theophylline supplementation could even counteract supplementation with AAS.

In theory though, there are probably several compounds which augment second messengers of the AR which could be beneficial.

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

Yes, its a nice idea and you`re correct AR insensitivity and GC insensitivity arent the same thing. My point, and poorly made was that nuclear receptors do exhibit down-regulation.

More on the subject:
An Error Occurred Setting Your User Cookie
 
Last edited:
Top