Onset Of Effects Of Testosterone Treatment And Time Span To Maximum Effects

Discussion in 'Men's Health Forum' started by Michael Scally MD, Jul 14, 2011.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [Recently, I noticed I was approaching my 5,000 post. It came as a surprise, a pleasant surprise. I wanted the 5,000th post to be somewhat meaningful when along came this study. I hope it is of value. Have a great day and thank you Meso!]

    Onset Of Effects Of testosterone Treatment And Time Span Until Maximum Effects Are Achieved

    Treatment of hypogonadal men with testosterone is rewarding, for the patients as well as the physician. The patient experiences, to his satisfaction, profound changes in his physical appearance and his mental make-up. The attending physician observes the changes the patient undergoes and rarely fails to be fascinated by the multitude of functions testosterone appears to have in the process of masculinization in the broadest sense

    While the effects of testosterone have been described in detail, relatively little attention has been given to the time these effects take to occur and achieve a full expression. This seems relevant. To the attending physician, monitoring the effects of administration of testosterone will be facilitated when it is known when certain effects can and should be expected. Patients like to receive information when the effects will set in. Further, this information is relevant for the design of clinical trials on testosterone replacement therapy. It is important to have information when an effect can be expected and when its maximum has been attained.







    Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.

    Design: Studies in PubMed on testosterone replacement so far providing information on time course.

    Results: Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer. Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks. First effects on erythropoiesis after 3 months, peaking at 9-12 months. Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy. Effects on lipids appear after 4 weeks, maximal after 6-12 months. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3-12 months. Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years. Effects on inflammation occur within 3 to 12 weeks. Effects on bone detectable after 6 months but continue at least for 3 years.

    Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.

    Attached Files:

    Last edited: Jul 14, 2011
  2. zkt

    zkt Member

    That, sir, is a most excellent 5000th post.:):tiphat
    Gonnabe hard to top this.
  3. CubbieBlue

    CubbieBlue Member

    Wow - great charts.

    Were these all hypogonadal men? What was the dosage? Frequency?
  4. CGrayx

    CGrayx Junior Member

    Brilliant post - but would also, like the guy above, like to know whether frequency, dosage, etc was measured or whether it was just TRT in general.
  5. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    A great review for those on TRT.
    LittleD90 likes this.
  6. Pericles

    Pericles Member

    The take away is that it can take a while, and one needs to be patient.
  7. Donzi

    Donzi Member

    Just stay on.
    its Science after 30 men tank. TRT keeps it real. PERIOD. I am so over the Haters.
  8. Pericles

    Pericles Member

    Technically, it is after 28. about 2 % a year or so. I have seen guys in the 700's who are 45, but that is the exception, not the rule.

    I have a long time friend and I sold him some D-aspartic acid and also I think I gave him some nolva.

    At 45, I thought his natty production would be low, but lucky bastid was measured at 750. I was discussing my trt doc, and he seemed interested. He also said he was interested in a cycle come spring. I told him the smart move was to stay all natural until that 750 dropped.
  9. akiravp82

    akiravp82 Member

    I wonder if the people on these charts were on gels or injections ? i would think gels would work alot faster and maybe these charts on based on injections ? never the less amazing post doc :)
  10. biceps72

    biceps72 Member

    outstanding post!!!! WOW!
  11. MarkHolland

    MarkHolland Junior Member

    This is a magnificent pots.

    Mark Holland
  12. tgrusso78

    tgrusso78 Member

    An interesting read for anyone considering, just starting or even months into a TRT regimen.
  13. Noblenutria

    Noblenutria Junior Member

    thank you for posting this. This is exactly the kind of information I was looking for. I have a question though. The rate at which people recover from low T must depend on the specific amount of T for specific people. The charts don't say how much T or hcg people are taking. The charts must assume that the hypogonadal men are being treated with the right amount of HCG or T for their unique problems and were diagnosed correctly.
  14. MR10X

    MR10X Member

    I think it also depends on the type of ester that the testosterone has. I was on ADT for 1 year and i was at 132 TT when i took a shot of sustanon 250 mg and by the 2nd day i was getting morning wood.
  15. Beergut75

    Beergut75 Member

    Very cool thanks for sharing!
  16. irishchamp

    irishchamp Member

    I saved all those graphs, hope you don't mind. Excellent info!
  17. integralbasic

    integralbasic Junior Member

    I'm assuming that the esters are the traditional injectable ethanate and cypionate and perhaps sustanon as well. But I'm not sure shorter esters would make a difference, as even longer esters achieve high end range blood levels in less than a day. There seems to be a delay between the blood level concentrations and the effective treatment of the symptoms which I don't really understand.

    This study shows levels in the high normal range, near supra physiological, hours after the first injection:

  18. TurkeyBacon

    TurkeyBacon Junior Member

    Thank you for bumping this thread up it is informative and reassuring. Im on trt for about 7 months now, on test cyp 100mg a week divided into two doses weekly and can attest to some of the studies, specifically the morning/nocturnal erections and sexual thoughts. That started at around the 2-3 week mark for me. My sense of well being/confidence returned at about 8 week mark I would say and sometimes would decrease and increase. My strength started really increasing around the 12-16 week mark and I would say I have maybe started to plateu. Probably because I started dialing in my diet again. I was actually lean when I started trt and have gained some fat since starting trt but that is in regards to my diet as my appetite has increased tremendously since starting. I regret that I was not diagnosed with anything other than "low test" from my gp as im not sure that I received the accurate diagnosis (My doc was eager to start me on trt) in any case, just thought I could share my experience.

    Have a good one everyone.
  19. mindblah

    mindblah Junior Member

    Should someone being treated for secondary hypogonadism with, say, clomid (but not test shots or gels) factor in an additional several weeks/few months to the estimates given in the paper?