Opioid-Induced Adrenal Insufficiency

Discussion in 'Men's Health Forum' started by Michael Scally MD, Oct 12, 2018.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Opioid-Induced Adrenal Insufficiency

    One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized.

    Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy.

    Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.

    Donegan D, Bancos I. Opioid-Induced Adrenal Insufficiency. Mayo Clinic proceedings 2018;93:937-44. https://www.mayoclinicproceedings.org/article/S0025-6196(18)30283-0/fulltext
  2. Thaistick

    Thaistick Member

    Is there any more you can post from this? I only get an error message when I click on the link. I'm very interested in this.
  3. balco

    balco Member

    Interesting. It doesn't state what happens when your levels are low though, I really interested in this because I know a ton of people on long term opiate treatment.