Pathogenesis and Diagnosis of Growth Hormone Deficiency

Discussion in 'Human Growth Hormone and Peptides' started by Michael Scally MD, Sep 23, 2019.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Pathogenesis and Diagnosis of Growth Hormone Deficiency

    In a landmark 1962 review of growth hormone, Raben wrote, “Pituitary growth hormone is distinctive in causing growth of almost all tissues and in increasing size without advancing maturation . . . .”

    Written in an era of hormone bioassays, before the introduction of peptide sequencing, his description has remained accurate with the subsequent development of rigorous growth hormone assays and the introduction of recombinant growth hormone for clinical use.

    This review discusses the production and action of growth hormone, the pathogenesis and diagnosis of adult growth hormone deficiency states, and the safety of growth hormone in adults.

    Melmed S. Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults. New England Journal of Medicine 2019;380:2551-62. https://doi.org/10.1056/NEJMra1817346


    According to the review article, insulin-induced hypoglycemia (insulin-tolerance test) is the reference standard for making the diagnosis of adult growth hormone deficiency.” Moreover, “isolated igf-1 measurements are of limited diagnostic use because levels in adults with growth hormone deficiency may still be within normal limits, and isolated low IGF-1 levels are more commonly due to aging or catabolic illness than to adult growth hormone deficiency.”
     

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    Old, Millard Baker and mands like this.