Post Orgasmic Illness Syndrome (POIS)

Discussion in 'Men's Health Forum' started by Michael Scally MD, Jan 17, 2011.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Semen Allergy Blamed For Post-Orgasm Sickness
    Semen Allergy Blamed For Post-Orgasm Sickness

    There's a mysterious phenomenon in which some men, immediately after having an orgasm, come down with a flu-like illness. Now Dutch scientists are saying these men may be allergic to their own semen.

    The condition is known as post-orgasmic illness sydrome, or POIS. Though it's been on scientists' radars for nearly 10 years, it's not commonly known by patients or doctors. Many men who experience the post-ejaculate sickness don't come forward and tell their doctor about it out of embarassment, experts suspect.

    Marcel Waldinger, a professor of sexual psychopharmacology at Utrecht University in the Netherlands, and his team analyzed 45 Dutch men who had been diagnosed with POIS. From Reuters:

    Waldinger also identified a treatment for POIS, known as hyposensitisation, which essentially desensitizes the recipient of the treatment. The men were given skin injections of their own semen -- first highly diluted and eventually increased -- and after one to three years symptoms were greatly reduced.

    Symptoms of POIS include fever, runny nose, extreme fatigue and burning eyes. They come on straight after climax and can last up to a week, reported The Sun.
     
  2. ctrlaltdel

    ctrlaltdel Junior Member

    Interesting. Sure glad I don't have that...
     
  3. zkt

    zkt Member

    Autoimmunity is being found to be at the root of more and more problems all the time.
    Isnt there another symdrome where the guy just feels tired and burned out for days or longer?
    But thats a hormonal thing, PRL, I think.
     
  4. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Waldinger MD, Meinardi MMHM, Zwinderman AH, Schweitzer DH. Postorgasmic Illness Syndrome (POIS) in 45 Dutch Caucasian Males: Clinical Characteristics and Evidence for an Immunogenic Pathogenesis (Part 1). The Journal of Sexual Medicine:no-no. http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2010.02166.x/abstract

    Introduction. Postorgasmic illness syndrome (POIS) is a combination of local allergic symptoms and transient flu-like illness. In this study, the investigators propose five preliminary criteria to establish the diagnosis.

    Aim. To describe the clinical details in 45 males being suspected of having POIS and to test an immunogenic hypothesis as the underlying mechanism of their presentations.

    Methods. Forty-five males were studied according to standardized protocol, including neuropsychiatric and medical sexological evaluations; their complaints were categorized using their own words, and their self-perceived intravaginal ejaculation latency time (IELT). Skin-prick testing with autologous diluted Clinical features?semen in 33 men were also performed. Main Outcome Measures. of POIS including self-perceived IELTs and the results of skin-prick testing with autologous diluted seminal fluid.

    Results. Of the 45 included men, 33 subjects consented with skin-prick testing. Of them, 29 (88%) men had a positive skin-prick test with their own (autologous) semen, and four had a negative test. In 87% of men, POIS symptoms started within 30 minutes after ejaculation. Complaints of POIS were categorized in seven clusters of symptoms, e.g., general, flu-like, head, eyes, nose, throat, and muscles. Local allergic reactions of eyes and nose were reported in 44% and 33% of subjects, a flu-like syndrome in 78% of subjects, exhaustion and concentration difficulties in 80% and 87% of subjects. Of all subjects, 58% had an atopic constitution. Lifelong premature ejaculation, defined as self-perceived IELT <1 minute, was reported in 25 (56%) of subjects.

    Conclusions. The combination of allergic and systemic flu-like reactions post-ejaculation together with a positive skin-prick test in the majority of males underscores the hypothesis of an “immunogenic” etiology of POIS, e.g., that POIS is caused by Type-1 and Type-IV allergy to the males' own semen, as soon it is triggered by ejaculation.


    Waldinger MD, Meinardi MMHM, Schweitzer DH. Hyposensitization Therapy with Autologous Semen in Two Dutch Caucasian Males: Beneficial Effects in Postorgasmic Illness Syndrome (POIS; Part 2). The Journal of Sexual Medicine:no-no. Hyposensitization Therapy with Autologous Semen in Two Dutch Caucasian Males: Beneficial Effects in Postorgasmic Illness Syndrome (POIS; Part 2) - Waldinger - 2011 - The Journal of Sexual Medicine - Wiley Online Library

    Introduction. Postorgasmic illness syndrome (POIS) is a post-ejaculatory complex of local and/or systemic symptoms that nearly always occurs within seconds, minutes, or hours post-masturbation, coitus, or spontaneous ejaculation. Recent data suggest an autoimmunogenic/allergic underlying mechanism.

    Aim. To treat males with POIS by hyposensitization with their own semen (autologous semen).

    Methods. Two males suffering from POIS, of which one male with coincidental lifelong premature ejaculation (PE) were investigated. Based on their local and systemic symptoms including a positive dermatologic reaction after skin-prick testing with autologous semen, auto-allergy to semen was likely an underlying mechanism. A hyposensitization program was initiated, including multiple subcutaneous (SC) injections with autologous semen, initially at 2 weeks intervals in the first year and gradually at 4 weeks intervals in the second and third year. From initial semen dilutions of 1 on 40,000 and 1 on 20,000, the titers were gradually increased to 1 on 20 and 1 to 280, respectively.

    Main Evaluation with a dedicated questionnaire about severity of?Outcome Measures. POIS symptoms and specialized interviews on self-perceived intravaginal ejaculation latency times (IELT) before and during the desensitization program.

    Results. POIS was confirmed in both subjects, PE was confirmed in one male, and skin-prick tests with autologous semen in both subjects were positive. During the program, gradual reduction of complaints resulted in 60% and 90% amelioration of POIS complaints at 31 and 15 months, respectively, which coincided in one male with a delay of the IELT from 20 seconds at baseline to 10 minutes after 3 years of treatment. The cause of this association with IELT is unknown and remains to be elucidated.

    Conclusions. Two males with POIS were successfully treated by hyposensitization with autologous semen, which supports an immunogenic/allergic etiology and underscores the clinical implication for immunological sexual medicine.
     
  5. ergomaniac

    ergomaniac Member

    hint hint. dont procreate.
     
  6. CubbieBlue

    CubbieBlue Member

    Here, cum in this vial and then we are going to inject it back into you. Wild.
     
  7. DragonRider

    DragonRider Junior Member

    My understanding is that orgasm is a histamine reaction. Some of these symptoms seem like excessive histamine.
     
  8. fit4life10

    fit4life10 Junior Member

    I've also heard of a case where the wife was allergic to her husbands semen. I think in her case she would get deathly sick.
     
  9. Dr JIM

    Dr JIM Member

    Think I'll let more qualified DOCs with considerably more time than I have to pursue such a bizarre food allergy, lol!
    :)
     
  10. BBC3

    BBC3 Member

    Perhaps this is the indicator for the truth in "heterosexuality" and hence where the alpha porno males derived "shooting it out on to women" and not even leaving it in there to risk getting any on ones self:eek: LOL. Leaving a penis in a vagina post orgasm when attempting to get a woman pregnant is certainly not helpful to the cause. Perhaps an official objection forming to the perversion of natural progression of the species being currupted by science...:rolleyes: Or perhaps nothing more than a highly subverted marketing effort by Kleenex Brand.... LOL:drooling:
     
  11. zkt

    zkt Member

    Yes it does. Part ot the Sx seems to be a stuffy nose. But I would think that a theraputic dose of glucorticoids, 50mg prednisone, would aleviate the Sx, which it doesnt. But cabergoline does. This points toward too much prolactin and likely improper levels of other neurotransmitters as well. The dopamine-serotonin balance seems to be off, or perhaps there is a sudden receptor disregulation. Acetylcholine appears to also be effected as the dick is dead as a doornail for a while. More to it that autoimmune reastion, I think. Very complicated.
    Anyone else experience this ?
     
  12. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Primary Headache Associated with Sexual Activity: Case Report

    We present a rare case of primary headache associated with sexual activity. A 48-year-old man presented with a severe headache during sexual intercourse, particularly at the time of orgasm. A diagnosis of type 2 primary headache associated with sexual activity was made, and he was started on indomethacin 25 mg to be taken 30 min before intercourse and propranolol 40 mg twice a day, following which he noted a dramatic improvement within in a week. The case highlights the importance of paying attention to the differential diagnosis. For this patient, prophylactic treatment with beta-blockers and/or preemptive therapy with indomethacin was successful.

    Utku U. Primary Headache Associated with Sexual Activity: Case Report. Med Princ Pract. Medical Principles and Practice - Primary Headache Associated with Sexual Activity: Case Report - FullText - Karger Publishers
     
  13. zkt

    zkt Member

    Beta- blockers are sometimes effective in migraine headaches, for what that worth. Speaking of DDx: I think maybe he was doing either BBC3`s or my wife.
     
  14. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Nguyen HMT, Bala A, Gabrielson AT, Hellstrom WJG. Post-Orgasmic Illness Syndrome: A Review. Sex Med Rev 2017. http://www.smr.jsexmed.org/article/S2050-0521(17)30116-6/abstract

    Introduction - Post-orgasmic illness syndrome (POIS) is a rare but debilitating cluster of postejaculatory symptoms affecting men. It is a chronic disorder manifesting as a constellation of flulike and allergic symptoms within seconds, minutes, or hours after ejaculation. POIS can be followed by mental sequelae such as diminished concentration and irritability. POIS negatively affects the life of patients by limiting sexual encounters, dampening romantic prospects, creating internal struggles to avoid eroticism, and affecting patients’ schedules.

    First described in 2002, the prevalence and incidence of POIS are still unknown owing to a paucity of studies but is likely under-reported. There are approximately 50 cases of POIS in the literature. Despite the debilitating effects of POIS, the pathophysiology of POIS is still not well elucidated.

    Aim - To provide an update on the current literature on POIS, provide updated information on the pathophysiology of POIS, and discuss potential management options.

    Methods - Comprehensive review of literature pertaining to POIS.

    Main Outcome Measures - The symptoms, classification, pathophysiology, diagnostic considerations, and management of POIS were reviewed.

    Results - There are 5 preliminary diagnostic criteria for diagnosing this condition. POIS is categorized as primary or secondary. The autoimmune-allergy hypothesis is the most accepted hypothesis explaining the pathogenesis of POIS. A competing hypothesis involves a disorder involving endogenous μ-opioid receptors. Another hypothesis invokes impairment of the cytokine and neuroendocrine responses.

    There are no known treatment modalities for POIS; patients have been symptomatically treated with antihistamines, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful. A trial of non-steroidal anti-inflammatory medication helped 1 patient described in a single case report, but failed to successfully treat other patients.

    Conclusions - POIS is a rare condition that is underdiagnosed and under-reported. Further studies are warranted to investigate the prevalence, pathophysiology, and treatment of this debilitating condition.


     
  15. Throwback

    Throwback Member

    Could it be that the male experiencing pois just realized what he just screwed?
     
  16. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    First Assessment of The Validity of The Only Diagnostic Criteria for Postorgasmic Illness Syndrome (POIS).

    Postorgasmic illness syndrome (POIS) is a rare condition that affects men and about which little is known. According to Waldinger and colleagues, men with POIS fulfill three or more of five preliminary diagnostic criteria regarding symptoms, time to onset, setting, duration, and spontaneous disappearance.

    We conducted a self-report study to assess, for the first time, the validity of these criteria. One hundred and twenty-seven men with self-reported POIS have completed the survey, making this the largest study of such men to date. Almost all respondents fulfill a majority of the criteria for POIS; a large minority fulfills all five criteria.

    Almost all respondents always experience symptoms after ejaculating in at least one ejaculatory setting (sex, masturbation, or nocturnal emission), though only a small majority fulfill the criterion that symptoms occur after all ejaculations because a large minority always experience symptoms in one setting but not always in another.

    The most common symptom cluster from the criteria, involving fatigue, irritation, and concentration difficulties, is always experienced by 80% of respondents. Median symptom severity is 8 on a 0-10 scale.

    While almost all men with POIS fulfill a majority of the preliminary diagnostic criteria, there is room for refining some of the criteria.

    Strashny A. First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS). International journal of impotence research 2019. First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS)
     
  17. Dr JIM

    Dr JIM Member

    What will they think of next
    Post Steroid Anorgasmic Syndrome?
     
  18. LeoTC

    LeoTC Member

    I dun told them bitches that's why I was crying everytime I nut.

    They just thought the Pussy was that good.
     
  19. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Post Orgasmic Illness Syndrome: What Do We Know Till Now?

    Background: Peri orgasmic dysfunctions are very rare and little information exists on their diagnosis and treatment. One of these conditions is post-orgasmic illness syndrome (POIS), manifesting by a debilitating cluster of symptoms affecting men within seconds, minutes, or hours after ejaculation. The aim of this article is to do a thorough literature review about POIS, in order to elucidate the pathophysiology, the diagnosis and the management of this rare disease.

    Results: Updated literature review on Pubmed was done, using the following terms: "orgasm illness", "post-orgasmic" and "postorgasmic illness syndrome". The references of the 17 identified publications were also reviewed for additional 8 relevant articles that were all included in the results.

    POIS has 5 preliminary diagnostic criteria and criterion 1 has 7 described clusters. Pathophysiological hypotheses include: immunological phenomenon (most relevant), opioid-like withdrawal, neuroendocrine response, transient deregulation of the autonomic nervous system, hypersensitivity and disordered cytokines.

    Differential diagnoses include: chronic prostatitis, orgasmolepsy, benign orgasmic cephalgia, sneezing and rhinorrhea, postcoital dysphoria, post-coital asthma and rhinitis. Patients have been symptomatically treated with antihistamines, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful.

    Conclusion: POIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options. Further studies are warranted to investigate the prevalence, pathophysiology, and management of this debilitating condition.

    Abdessater M, Elias S, Mikhael E, Alhammadi A, Beley S. Post orgasmic illness syndrome: what do we know till now? Basic Clin Androl 2019;29:13. Post orgasmic illness syndrome: what do we know till now?
     
  20. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Successful Treatment of Post-Orgasmic Illness Syndrome with Human Chorionic Gonadotropin

    Post-orgasmic illness syndrome (POIS) is an uncommon condition in which men experience debilitating symptoms following orgasm, including anxiety, weakness, and lassitude. The etiology is unknown, and treatment challenging.

    We present a 25y man with POIS since puberty. He dreaded ejaculation due to his subsequent symptoms. Multiple prior treatments had failed. Blood tests revealed testosterone (T) deficiency. hcg was prescribed. At 6 weeks T levels normalized with near-complete resolution of symptoms.

    This successful result argues for hormonal investigation in men with POIS, and a trial of hCG or T therapy if total or free T is low or borderline.

    Bolanos J, Morgentaler A. Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin. Urol Case Rep. 2019;29:101078. Published 2019 Nov 22. Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin - ScienceDirect