Process of Making Testosterone

Discussion in 'Steroid Homebrew' started by BIGMESC, Jan 12, 2015.

  1. BIGMESC

    BIGMESC Member

    This has been discussed in a few other thread and in an effort to make MESO-RX
    the Library of Alexandria of the PED world, I though if its out there we should have it here.

    I will post up some information that is freely available on the web for theoretical research purposes only, of course.

    If anyone has comments, questions or additional information, please participate and post them.
     
    Last edited: Jan 12, 2015
  2. BIGMESC

    BIGMESC Member

    Copy and pasted from EF with discussion

    How to make test from dhea
    experimental: DHEA was purchased from china in one kg quantity, methanol
    or methylhydrate from canadian tire, sodium borohydride from a hydrogen
    cell engine supplier online fifteen grams for fifteen dollars, good for
    60 grams test. 10 grams DHEA dissolved in 400ml methanol and stirred using
    a milk frother in a regular glass nestled in ice. 2.5 grams sodium boro are
    slowly added as powder at a rate that does not allow the temp to exceed 40C.
    if a slurry forms thats good, it means product is forming, just add more cold
    methanol. after a total of one hour add vinegar until the bubbling on addition
    stops then dump into a liter of ice water. filter thru coffe filter and squeeze
    dry. dry in oven at 60C. activated manganese dioxide is made from manganese
    dioxide from a ceramics supplier and then its boiled in nitirc acid to activate.
    make nitric acid by adding boiled down battery acid to stump remover
    (potassium nitrate) then boiling inside a bottle with a hose running to another
    bottle nestled in ice to collect the nitric acid. filter and rinse with an anhydrous
    solvent like a fuel system water remover, activated mang diox must be absolute dry.
    put the diol from the first step in 300ml acetic acid then slowly add the mang diox as
    a powder same fashion as above, stir for six to ten hours, you won't over oxidize
    since exact molar equivalents are used. now flood the reaction with five times volume
    ice water and filter out the base test plus unreacted diol and DHEA, minimum purity
    will be about 70%
    Basically you're reducing the carbonyl in DHEAto form a diol which is then randomly oxidized (testosterone product favorable) to get at least 70% testosterone. The problem is that the position of the double bond in DHEA... It is one carbon away from where it is in testosterone... Does anyone have any ideas? How can this problem be solved or does it need to be solved? Do you think the hormone will work like testosterone to some degree?

    many of you have seen my other posts about making steroids synthetically but always in the context of a laboratory setting, a masters in organic synthesis etc.. Lord knows over the years i have had my hands in a fair number of batches of a multitude of steroids, many of you have probably tasted my fruits but will never know.
    myself and the boogeyman set out to attempt to do this synthesis with absolutely nothing from a scientific supply house, no glassware, no ph papers no fuck all. We succeeded and ended up with base test so pure it crystallized like shattered glass.
    THEORY: DHEA is two synthesis steps away from test base, one oxidation, one reduction. The most logical way is to reduce first the 17=O to create 5 androstenediol, this way there are many selective oxidation agents that will only convert the 3-OH to a =O and not the 17. Since DHEA is not water soluble one can not use water as a solvent for the reaction, the obvious choice is methanol since the reduction is done with sodium borohydride. A large excess of methanol is used because 5androdiol is much less soluble in methanol than DHEA so as it is formed it will slurry. The second step is full of possibilities but the available selective oxidizer is manganese dioxide, in this case the reaction is done in acetic acid which gives slight solubility to the androdiol to transiently come in and out of solution to react

    experimental: DHEA was purchased from china in one kg quantity, methanol or methylhydrate from canadian tire, sodium borohydride from a hydrogen cell engine supplier online fifteen grams for fifteen dollars, good for 60 grams test. 10 grams DHEA dissolved in 400ml methanol and stirred using a milk frother in a regular glass nestled in ice. 2.5 grams sodium boro are slowly added as powder at a rate that does not allow the temp to exceed 40C. if a slurry forms thats good, it means product is forming, just add more cold methanol. after a total of one hour add vinegar until the bubbling on addition stops then dump into a liter of ice water. filter thru coffe filter and squeeze dry. dry in oven at 60C.
    activated manganese dioxide is made from manganese dioxide from a ceramics supplier and then its boiled in nitirc acid to activate. make nitric acid by adding boiled down battery acid to stump remover (potassium nitrate) then boiling inside a bottle with a hose running to another bottle nestled in ice to collect the nitric acid. filter and rinse with an anhydrous solvent like a fuel system water remover, activated mang diox must be absolute dry. put the diol from the first step in 300ml acetic acid then slowly add the mang diox as a powder same fashion as above, stir for six to ten hours, you won't over oxidize since exact molar equivalents are used. now flood the reaction with five times volume ice water and filter out the base test plus unreacted diol and DHEA, minimum purity will be about 70%

    note we activated mang diox by azeotropic distillation with benzene as we are too lazy to make nitric acid.

    75 grams of DHEA can be had for about a buck a gram, all together maybe 2-4 dollars a gram for heat free decent test.
    Bremac can correct me if I'm wrong, and there could possibly be a better way, but I think the usual route would be esterification using the corresponding acid anhydride (ie: propionic anhydride for propionate ester) in pyridine. The anhydride would be used in excess to drive the reaction to the desired product, since its an equilibrium rxn.
    yes you can use the anhydride and that is in fact the premier way to go, but i triple do dare you to order propanoyl anhydride in the united states, even acetic anhydride is hot. If you go with the carboxylic acid it works but is longer reaction, plus you can form the acyl chloride from the acid which in pyridine is in my opinion just as good as the anhydride
    there would be no reason at all that would make using the stuff dangerous. starting from DHEA and reacting with sodium borohydride can produce ONLY one thing.......5androdiol. so you can have diol or DHEA, thats it, sodium borohydride is soluble in water so when you flood the first reaction with water the hormones precipitate (become solid and filterable) and the borohydride stays behind in the liquid.

    in the second step with dichromate as long as it is kept cold the only possible products are unreacted diol, DHEA, testosterone or androdione. the steroid skeleton lacks and signifigant chemical groups capable of allowing dangerous side reactions and by products. again dichromate is soluble in water so no contamination.

    you guys need confidence in yourselves, you may not really know what i'm talking about but I don't know the difference between a dumbell and a barbell, we all have areas of expertise, i'm sure i could go workout at a gym and come out alive just as you would coming into my world.

    anyone who is considering something like this should pm me there are very sympathetic chemical suppliers out there, i of course know them all.
    Yeah I was thinking the acyl chloride should work as well...and in pyridine you get the pyridine HCl instead of having to worry about generating HCl gas.
    Haha I love your posts dude.
    And yeah...definitely do NOT try to order acetic anhydride....used in the manufacture of heroin, and even small amounts are reportable.
    I'm glad you brought up the thing about my comment on using a carboxylic acid to form an ester. \this is really an equilibrium reaction and the products are only slightly favoured so a huge excess of an expensive and dangerous to obtain material like propionic acid would need to be employed and still you would get lots of unreacted material that has really only some type of preparative chromatography as a means of separation being that the solubilities are the same.
    Propionic calcium salt is available easily on ebay, this can be acidified and distilled at low temp, then chlorinated with Nchlorosuccinamide or chlorine gas or thionyl chloride etc.. its a bit of work but done in decent amount you only do it once.
    still it makes more sense to use acetyl chloride, it would form test acetate, themost expensive of the test esters. for what reason i have no clue. vinegar flavoured testosterone.
     
    Last edited: Jan 12, 2015
    RThoads, devildog93 and flenser like this.
  3. BIGMESC

    BIGMESC Member

    US patent 2109400

    Patented Feb. 22, 1938 UNITED STATES ESTERS 0F testosterone AND PROCESS OF MAKING SAME Karl Miescher, Riehen, near Basel, and Albert Wettstein and Caesar Scholz, Basel, Switzerland, assignors to the flrm of Society 0! Chemical Industry in Basie, Basel, Switzerland No Drawing. Application September 8, 1936, Se
    rial No. 99,856. In 1935 16 Claims.
    This invention relates to the manufacture of new esters of saturated or unsaturated oxyketones of the type of androstane-S-one-l'l-ol by treating the oxyketone with an acylating agent having more than two carbon atoms and containing in addition to the acylating group no group havinga tendency to form salt or group capable of conversion into a salt-forming group.
    As compared with testosterone and testosterone-acetate thenew esters are characterized by their protractive eifect. Esters derived from medium fatty acids, from propionic acid onwards, have proved to have a particularly strong eflicacy in tests on rats.
    For the acylation either the free acid itself I or its anhydride, halide or ester derived from a lower alcohol may be used. Suitable acid components are, for instance, propionic acid, butyric acids, valerianio acids, capric acid, benzoic acid, crotonic acid or the like.
    The following oxyketones are examples of the parent materials: testosterone (A -androstene- 3-one-1'7-ol), dihydrotestosterone (androstene- 3-one-17-ol), 1'7-methyl-testosterone (A -17- methyl-androstene-3-one- 17-01) 17 -methyldihydrotestosterone (17-methyl-androstane-3-one 17-01).
    The new products have been tested biologically by the following methods:
    (A) Castrated rats received on the 1st and 6th experimental days each 1 mg. of the compound to be investigated. On the 16th or 21st day the rates were killed and the weight of the seminal vesicles were ascertained.
    (B) Castrated rats received on the 1st experimental day 2 mgs. of the compound to be investigated. On the 6th and 11th days the rats were killed and the weights of the seminal vesicles were ascertained.
    The following table shows the particularly high activity of the new products as compared with the known testosterone, its acetate and the dihydrotestosterone Weight of seminal vesicle of the rat in mg. 7 Compounds investigated Method A Method 16 days 21 days 6 days 11 days Testosterone l5 14 18 14 Dihydrotestosteroncn 15 i4 18 14 l7-methyl-testosterone 16 14 27 17 l7-methyl-dihydrotestosteronc 16 14 25 16 Testosterone-formate 61 46 86 35 Testosterone-meta te 89 33 93 41 Testosterone-propionate 285 106 101 265 Testosterone-n-butyrate 375 320 130 306 Testosterone-iso-butyratc 334 135 150 312 Testosterone-n-va1eriauate 400 514 140 235 Testosterone-caprinate 165 190 58 7 Testosterone -benzoate 113 170 Dihydrotestcsterone-formate 40 Dihydrotestosterone-acetate 35 Dihydrotestosterone-proplonatea 230 Switzerland October 5,
    The new esters are applicable in therapeutics. The following examples illustrate the invention, the parts being by weight:-
    Example 1 1 part of testosterone is dissolved in 4 parts of dry pyridine and the solution is heated with 1.5 parts of propionic acid anhydride for 1 .hours at C. The whole is then poured into water and allowed to stand for some time during which crystallization occurs. The crystalline mass is filtered by suction, washed with water, dried over phosphorous pentoxide and re-crystallized from hexane; colourless testosterone propionate is thus obtained of melting point 121-123 C.
    The reaction may occur in the presence of another tertiary base or even in the absence of such a base.
    Example 2 A solution of 1 part of testosterone in 4 parts of pyridine is heated with 2 parts of n-butyric acid anhydride in an oil bath at 125 C. for 1 hours. Water-is then added and the mixture allowed to standfor a long time during which crystallization occurs. The crystals are filtered by suction, washed with water and dried over phosphorus pentoxide. When re-crystallized from hexane or dilute methanol the product yields testosterone-n-butyrate in the form of slender needles which melt at Ill-113 C.
    Example 3 1 part of testosterone is dissolved in 3 parts of dry pyridine and the solution is heated together with 2 parts of iso-butyric acid anhydride at 125 C. for 2% hours. The mass is then poured into warm water and stirred somewhat; after a short time crystallization begins.- The crystals are filtered by suction, washed with water and dried over phosphorus pentoxide. After recrystallization from hexane or dilute acetone testosterone-iso-butyrate is obtained in the form of thick needles of melting point 134-136 C.
    Example 4 Instead of valerianic acid chloride another halide of the acid may be used, for instance bromide.
    In like manner, one can obtain the iso-valerianic acid ester of melting point 138-139.5 C.
    Example 5 Equal parts of testosterone and capric acid are heated together in an atmosphere of nitrogen for 3 hours at 200 C. The mass is then taken up with ether, the ethereal solution being washed with sodium carbonate solution and water and then evaporated. The residue which crystallizes after standing for some time is re-crystallized from absolute alcohol or aqueous methyl alcohol so as to obtain the testosterone capric acid ester of melting point 555'7 C.
    In quite analogous manner for example the esters of capronic acids, oenanthic acids, caprilic acids, pelargonic acids and the like may also be obtained.
    Example 6 1.44 parts of testosterone is dissolved in absolute pyridine and to this solution 1 part of benzoyl chloride is added. The mixture is allowed to stand'for several hours and then poured into dilute sulfuric acid; the mass is then extracted with ether and the ethereal extract is washed repeatedly with dilute acid, dilute caustic soda solution and finally water. The residue of the dried ether solution is purified by re-crystallization from hexane or by sublimation in a high vacuum or by both methodsoi purification, whereby the testosterone benzoate of melting point 198 200 C. is obtained.
    17-alky1-testosterones such as, for example, the 17-methyl compound or the 1'7-ethyl compound are esterified in analogous manner, for example the propionates, butyrates, valerianates,
    benzoates and the like are produced as crystalline compounds.
    Example 7 In quite analogous manner the butyric acid ester of melting point 91-92" C., and the n-valerianic acid ester and other esters may be obtained.
    1'7-alkyl-dihydrotestosterones such as, for example, the 17-methyl compound or the 17-ethyl compound are esterifled in analogous manner, for example the propionates, butyrates, valerianates, benzoates and the like are produced as crystalline compounds. 4
    In like manner there may be made, for instance androstane 3 one-l'l-trans-ol-hexa-hydrobenzoate of melting point 165-166 C. and androstane 3 one 1'7 cis-olhexahydrobenzoate of melting point 13613'7 0.,
    What we claim is: 1. 'The 3 keto-cyclopentanopolyhydrophenanthrenes containing in PI-position the group wherein R is a member of the group consisting of hydrogen and a lower aliphatic hydrocarbon radical, and Ac stands for an unsubstituted monocarboxylic acid radical containing more than two carbon atoms.
    2. The 3-keto-cyclopentanopolyhydrophenanthrenes containing in l'l-position the group wherein R, is a member of the group consisting wherein R. is a member.o1' the group consisting of hydrogen and a lower aliphatic hydrocarbon radical.
    5. The 3-keto-cyclopentanopolyhydrophenanthrenes containing in l'l-position the group \O'COC4H wherein R is a member of the group consisting of hydrogen and a lower aliphatic hydrocarbon radical.
    6. The testosterone propionate o! the formula of melting point 121-423 C.
    7. A process for the manufacture of esters of the B-keto-cyclopentanopolyhydrophenanthrenes containing in 17-position the group wherein R is a member of the group consisting of hydrogen and a lower aliphatic hydrocarbon radicaL-consisting in treating the said B-ketocyclopentanopolyhydrophenanthreneswithagents capable of introducing unsubstituted monocar:
    boxylic acid radicals containing more than two carbon atoms. a
    8. A pro ess for the manufacture of esters of the 3-keto-cyclopentanopolyhydrophenanthrenes containing in l7-position the group wherein R is a member of the group consisting in hydrogen and a lower aliphatic hydrocarbon radical, consisting in treating the said 3-ketocyclopentanopolyhydrophenanthrenes with allphatic agents capable of introducing unsubstituted monocarboxylic acid radicals containing more than two carbon atoms.
    9. A process for the manufacture of propionates of the -3-keto-cyclopentanopolyhydrophenanthrenes containing in 17-position the group wherein R. is a member of the group consisting of hydrogen and a' lower aliphatic hydrocarbon radical, consisting in treating the said 3-ketocyclopentanopolyhydrophenanthrenes with propionylating agents.
    10. A process for the manufacture of butyrates o f t h e 3-keto-cyclopentanopolyhydrophenanthrenes containing in 17-position the group \OH wherein R. is a member of the group consisting of hydrogen and a lower aliphatic hydrocarbon radical, consisting in treating the said S-ketdcyclopentanopolyhydrophenanthrenes with butyrylating agents.
    11. A process for the manufacture of valerianates of the 3 keto cyclopentanopolyhydrophenanthrenes containing in l'l-position the group wherein R is a member of the group consisting of hydrogen and a lower aliphatic hydrocarbon radical, consisting in treating the said 3-ketocyclopentanopolyhydrophenanthrenes with valerianylating agents.
    12. A process for the manufacture of testosterone-propionate of the formula (IJH: /H
    O-CO-CHr-CH:
    wherein testosterone of the formula is treated with a propionylating agent.
    13. The testosterone-n-butyrate of the formula CH1 OH.
    I :-C00HrCHr-CHa of melting point 111-113 C.
    14. The testosterone-n-valerianate of the formula of melting point 109-111 C.
    15. A process for the manufacture of testosterone-n-butyrate of the formula CH: CH,
    I -c0-cmcmom wherein testosterone of the formula OH: on, I
    is treated with a n-butyrylating agent.
    16. A process for the manufacture of testosterone-mvalerianate of the formula CH! CH:
    is treated with a n-valerianylating agent.
    ALBERT WE'ITS'I'EIN. CAESAR SCHOIZ.
     

    Attached Files:

  4. BIGMESC

    BIGMESC Member

    US patent 2236574

    "SYNTHESIS OF testosterone FROM DHEA
    Testerone from bacteria culture US Patent # 2,236,574
    Suspend 40g yeast in 160 ml water and add, if possible, 1.5g of disodium hydrogen phosphate and potassium dihydrogen phosphate. Shake in oxygen atmosphere for 1 day and then add lg (1000mg) DHEA suspended in 150ml of water and shake for another 2 days in oxygen atmosphere. Then add 130g invert sugar (or brown sugar or honey) and let stand 3 days at room temperature. The mixture is then extracted with three 50ml portions of ether (shaken with the ether then the ether separated) or methylene chloride, and the ether washed by shaking with water and separating ether solution. Evaporate ether to get testosterone.
    SYNTHESIS OF ESTER OF TESTOSTERONE (cypionate and propionate)
    Dissolve 5g testosterone (or analog) in 25mi pyridine or dry ether and add 3g propionic anhydride (or propionyl chloride) OR cypionyl chloride(cyclopentylpropionyl chloride) to get the propionate and cypionate respectively. Let stand over night and add excess water, filter, wash, and dry.
    Steroids Related to Testosterone
    Oil-soluble derivatives of testosterone itself predate those of its 19-nor congener, these agents too are used to administer depot injections so as to provide in effect long term blood levels of drug. Thus, acylation of testosterone with propionyl chloride in the presence of pyridine yields testosterone propionate; acylation by means of decanoic anhydride yields testosterone decanoate. Finally, reaction with 3-cyclopentylpropionyl chloride affords testosterone cypionate. This last undergoes hydrolysis unusually slowly because of the presence of two substituents at the 6 postion.
    Reaction of dehydroepiandrosterone (DHEA) with an excess of methylmagnesium bromide affords the 17a-methyl compound; again the aforementioned stedc effects lead to high stereoselectivity. Oppenauer oxidation of the resultant intermediate proceeds with a shift of the double bond into conjugation to yield methyltestosterone. When the initial condensation is canted out with the Grignard reagent from allyl bromide instead, this sequence yields allylestrenol. Perhaps most startling is the fact that the product obtained from the use of a metal acetylide in this synthesis . ethisterone, shows little if any, if any androgenic potency. Instead, the compound is an orally effective progestin.
    These agents have all been used at one time as orally active anabolic-androgenic agents. Dehydrogenation of methyltestosterone by means of chloranil extends the conjugation to afford the 4,6-diene-3-one- system. This compound in turn undergoes 1,6 conjugate addition of methylmagnesium bromide in the presence of cuprous chloride to afford largely the 6a-methyl product,known as bolasterones. Dehydrogenation with selenium dioxide, on the other hand, affords the cross conjugated diene, aka Dianabol.
    Hydroxylation of the double bond of methyltestosterone by means of osmium tetro dde and hydrogen peroxide afford the 4,5 diol. This undergoes beta elimination on treatment with base to yield oxymestrone.
    Catalytic reduction of DHEA goes as expected largely from the unhindered side of the molecule to afford a trans A/B dng fusion. Reaction with methyl Grignard reagent followed by oxidation of the intermediate yields androstanolone (1). Formylation of (1) with ethyl formate and base gives oxymetholone (aka Anadrol), Catalytic reduction of the analogous hydroxmethylene compound from dihydrotestosterone propionate gives first the 28-methyl product. Treatment with base leads this to isomerize to the thermodynamically favored equatedal 2a-methyl compound., dromostanolone propionate. The formyl ketone undergoes a reaction typical of this fuctional array on treatment with hydazine, leading to formation of the anabolic steroidal pyrazole, stanazole."
    SYNTHESIS OF TESTOSTERONE FROM DHEA
    Testerone from bacteria culture
    US Patent # 2,236,574

    Suspend 40g yeast in 160 ml water and add, if
    possible, 1.5g of disodium hydrogen phosphate and
    potassium dihydrogen phosphate. Shake in oxygen
    atmosphere for 1 day and then add lg (1000mg) DHEA
    suspended in 150ml of
    water and shake for another 2 days in oxygen
    atmosphere. Then add 130g invert sugar (or brown sugar
    or honey) and let stand 3 days at room temperature.
    The mixture is then extracted with three 50ml portions
    of ether (shaken with the
    ether then the ether separated) or methylene chloride,
    and the ether washed by shaking with water and
    separating ether solution. Evaporate ether to get
    testosterone.

    SYNTHESIS OF ESTER OF TESTOSTERONE
    (cypionate and propionate)

    Dissolve 5g testosterone (or analog) in 25mi pyridine
    or dry ether and add 3g propionic anhydride (or
    propionyl chloride) OR cypionyl
    chloride(cyclopentylpropionyl chloride) to get the
    propionate and cypionate
    respectively. Let stand over night and add excess
    water, filter, wash, and dry.


    Steroids Related to Testosterone

    Oil-soluble derivatives of testosterone itself predate
    those of its 19-nor congener, these agents too are
    used to administer depot injections so as to provide
    in effect long term blood levels of drug. Thus,
    acylation of testosterone with propionyl chloride in
    the presence of pyridine yields
    testosterone propionate; acylation by means of
    decanoic anhydride yields testosterone decanoate.
    Finally, reaction with 3-cyclopentylpropionyl chloride
    affords testosterone cypionate. This last undergoes
    hydrolysis unusually slowly because of the presence of
    two substituents at the 6 postion.

    Reaction of dehydroepiandrosterone (DHEA) with an
    excess of methylmagnesium bromide affords the
    17a-methyl compound; again the aforementioned stedc
    effects lead to high stereoselectivity. Oppenauer
    oxidation of the resultant
    intermediate proceeds with a shift of the double bond
    into conjugation to yield methyltestosterone. When the
    initial condensation is canted out with the Grignard
    reagent from allyl bromide instead, this sequence
    yields allylestrenol. Perhaps most startling is the
    fact that the product obtained
    from the use of a metal acetylide in this synthesis .
    ethisterone, shows little if any, if any androgenic
    potency. Instead, the compound is an orally effective
    progestin.

    These agents have all been used at one time as orally
    active
    anabolic-androgenic agents. Dehydrogenation of
    methyltestosterone by means of chloranil extends the
    conjugation to afford the 4,6-diene-3-one- system.
    This
    compound in turn undergoes 1,6 conjugate addition of
    methylmagnesium bromide in the presence of cuprous
    chloride to afford largely the 6a-methyl product,known
    as bolasterones.
    Dehydrogenation with selenium dioxide, on the other
    hand, affords the cross conjugated diene, aka
    Dianabol.

    Hydroxylation of the double bond of methyltestosterone
    by means of osmium tetro dde and hydrogen peroxide
    afford the 4,5 diol. This undergoes beta elimination
    on treatment with base to yield oxymestrone.

    Catalytic reduction of DHEA goes as expected largely
    from the unhindered side of the molecule to afford a
    trans A/B dng fusion. Reaction with methyl Grignard
    reagent followed by oxidation of the intermediate
    yields androstanolone (1). Formylation of (1) with
    ethyl formate and base gives
    oxymetholone (aka Anadrol), Catalytic reduction of the
    analogous hydroxmethylene compound from
    dihydrotestosterone propionate gives first the
    28-methyl product. Treatment with base leads this to
    isomerize to the thermodynamically favored equatedal
    2a-methyl compound., dromostanolone
    propionate. The formyl ketone undergoes a reaction
    typical of this fuctional array on treatment with
    hydazine, leading to formation of the anabolic
    steroidal pyrazole, stanazole.
     

    Attached Files:

    Jayman likes this.
  5. BIGMESC

    BIGMESC Member

    Copy and paste from EF

    how to make 4-androstenediol from DHEA
    You reflux (boil) 0.6g (notice the decimal point) of sodium hydroxide (crystal clog remover) in 250ml (one quarter Liter) anyhydrous isopropanol (rubbing alcohol) until it dissolves (goes away.) After allowing it to cool to 20C (room temperature) add 5g (no decimal point)or a stoichiometric amount (the same amount of molecules of) DHEA to the mixture. Watch it turn immediately yellow (piss-colored. Isn't refractrometry special?) Bring it to reflux (boil it some more) via microwave irradiation (put it in the microwave on defrost,) for a total of six minutes in 30-90 second increments (half-a-minute to a minute and a half.)

    Work up (gettin' the stuff you want out,) is facilitated (done) via aqueous elution (pour COLD water in until it looks like milk. DO NOT DRINK!!!) Set aside (go watch TV) for 30 minutes (half an hour.) Purification (getting the poisonous bits out) is achieved via gravity filtration (use your mom's coffee pot.) Press (wring it out) and dessicate (put in ziplock with the clear kind of kitty litter) until dry.

    Note that this procedure produces the largely biologicially inactive Δ-5 system. However, you will have synthesized the aforementioned diol in respectable yield. Conversion to the Δ-4 system is accomplished via reductive oxidation of the 3-hydroxyl system to it's corresponding ketone under mildly acidic conditions. (keto-enol tautomerism is largely responsible for the migration of the double bond, and the intermediary is protonated by the appropriate Brønsted-Lowry acid to yield the desired Δ-4 system.) The resulting 3-enone is then reduced by any number of appropriate means, (lithium-aluminium hydride, catalyitic hydrogenation, or microbial assisted enzymatic synthesis,) to yield your desired prohormone.

    Best of luck! Try not to get exploded!
     
  6. I should have took chemistry in school , another regret . This goes right over my head but is very interesting . testosterone made from DHEA ? Didnt know it could be done ....
     
  7. BIGMESC

    BIGMESC Member

     
  8. BIGMESC

    BIGMESC Member

     
  9. jymis

    jymis Member

    Even though they say this doesn't produce dangerous by products it still scares me. I think this is def something i want to work on getting up the nerve to do.
     
  10. Bradly

    Bradly Member

    In at least one of the above synthesis above, nitric acid is mentioned as well as a simplified distillation method.
    1. Nitric acid is used in the synthesis of most explosives. Watched? you betcha
    2. Home distillation is not easy and can evolve poisonous gas, do not use some anarchist crapbook method to make your own nitric acid you will wind up dead of pulminary edema.
    on a 1 to 10 scale its a 6, and if you can pull it off, you can make your own semtex ;)
     
  11. A-a-Ron

    A-a-Ron Member

    Good reading, but holy fuck...I'd rather make meth for the following reasons:
    1). The person taking it has a death wish anyway.
    2) You have a better chance of blowing yourself up making this shit.
    3). The cops will think you are making meth anyway, so why not make something that you get more profit per gram?
    4) a tweeker is not going to do a lab max or get bloods
     
    IronBrothers, Nick9, BIGMESC and 2 others like this.
  12. Jayman

    Jayman Member

    The one where you add sugar at one point to the dhea in order to make test prop/cyp is freaking awesome seems too easy. I know just because its a patent doesnt mean its scientifically true/possible...
     
  13. Warrior Saint

    Warrior Saint Junior Member

    Nice post, i have that same DHEA conversion recipe, just never had the stones to try it.
     
  14. A-a-Ron

    A-a-Ron Member

    I'd be so worried about leaving something in it that would melt my insides that I'd ruin it in the final steps.
     
  15. Semi- on topic, Does Test Prop oxidize at its original melting point in solution?