Prolactin what controls it & how much is too much

Discussion in 'Men's Health Forum' started by gregxy, Mar 22, 2006.

  1. #1

    gregxy Junior Member

    I have been on TRT for a few months but it has not done much in
    terms of sex. (My T level went from 380 - 1000). I have tried estrogen
    blockers at various levels (ATD, DIM, letrozole) and they help but
    not enough. The TRT did work at first but seemed to wear off after
    a few weeks.

    The only hormone that was out of the ref range was
    prolactin at 15 [3 - 13]. The Dr did an MRI but found nothing.

    The literature says prolactin supresses sex drive by reducing Test AND
    some other mechanism that is not understood, however usually this
    is in guys with prloactemia where the prolactin level is over 100.

    I'm thinking of getting some cabergoline and trying it. Anyone out there
    know more about prolactin?

    I've never done steroids but my sex drive always has been low and
    now it is getting lower as I get older.

  2. #2

    marianco Doctor of Medicine

    Dopamine controls prolactin levels - reducing prolactin release from the pituitary. testosterone increases dopamine levels.

    When testosterone is high but libido is low, among some thoughts:
    1. Is enough DHT being made from testosterone? DHT (dihydrotestosterone) is the active form of testosterone in the brain that promotes libido. DHT can be increased by using a transdermal testosterone - with the highest amounts if placed on the scrotum. DHT can also be used directly in a transdermal gel. Some men who genetically have low alpha-reductase activity (who happen to also have a full head of hair as a result), may have low DHT and low libido.
    2. Is there too much estrogen or too little estrogen activity? An aromatase inhibitor or Diindoylmethane or Indol-3-Carbinol can be used to adjust estrogen level downwards until the correct amount is achieved.
    3. Is there some unidentified hormone from the testes which improves libido? hcg treatment often increases libido more often than by using testosterone alone. The testes make more than 17 other hormones, including progesterone and oxytocin, which may have a role in increasing libido.
    4. Is progesterone low? This and low DHEA are some of the clues that adrenal fatigue is present. Adrenal fatigue needs to be addressed in order to have adequate energy and hormones for libido.
    5. Is dopamine level functionally low despite the increase in testosterone/DHT, since testosterone/DHT increase dopamine levels? For whatever reason (including Parkinson's disease or depression or ADHD, etc.), if dopamine level is too low, libido will be low. Low dopamine results in high prolactin. Some cases of ADHD involve dopamine-resistance. Higher dopamine levels are needed to get the same effect as normal attention people. In these cases, the use of a stimulant or other medication that increases dopamine may be useful.
  3. #3

    jawbone Junior Member

    vit B6 will lower prolactin if thats what you want to do.
  4. #4

    heavyuser Junior Member


    Is this explanation of my problem, when i am on the steroid cycle ( testosteron 1000mg weekly), also have dificulties with erections, and libido is very low???
  5. #5

    chap Junior Member

    could be an explanation, or not

    blood tests would help

    I've had poor libido on testosterone even when prolactin was low

    there are many many hormones and variables to consider, prolactin is only one of them
  6. #6

    gregxy Junior Member


    Has it been shown that testosterone controls dopamine or are they
    just correlated? There is plenty of evidence that prolactin suppresses
    testosterone (as in prolactemia) so if they are corelated it could be
    dopamine which controls testosterone (through prolactin)

    If test does enhance dopamine then it appears that there may be a positive
    feedback loop: dopamine suppresses prolactin, prolactin suppresses
    testosterone, and testosterone enhances dopamine. (two negatives
    make a positive). Positive loops
    can be unstable and "lock" in a high or low state. A loop like this
    could explain how steroid users shut down their HPTA system.

    I believe that estrogen enhances prolactin so a strong estrogenic
    steriod could trigger this mechanism.

    Prolactin in the normal range may reduce test. See the attached
    paper, the normal range is stated as < 20, yet for some of the
    subjects Test levels did not start to rise until prolactin was below 20
    (see fig 1)

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