SARMs are like steroids 2.0

[m314]

I was interested in RAD140 (testolone) for it's supposed prostate benefits. Some guys say it prevents prostate enlargement on steroid cycles with compounds like masteron. I only lasted 2 days on it. I was running low dose test and trest at the time and feeling great. As soon as I added RAD140, I felt pissed off and irritable all day. This happened twice in two weeks. I didn't know that was a side effect until I looked it up.

Ostarine felt like a really mild anavar to me. LGD-4033 gave me high blood pressure with no actual gains. I haven't found a SARM yet that can compare to actual steroids in terms of gains and side effects.

 

[jwarr]

As a pharmacist, I gotta admit, I'm amazed by some of the ignorance in this thread. SARM's are any drugs that have differential effect on the various AR-expressing tissues. Trestolone (MENT) is a well known SARM with a steroid structure. YK11 is a less tested, but similarly steroid-structure SARM. To dismiss the non-steroid SARM's are somehow inferior out of hand is silly. All drugs exist on a spectrum, and they can range from unsafe (DNP, cardarine, etc), probably not great for you (clenbuterol, YK11), to reasonably safe (trestolone, RAD-140).

Without a doubt, the prostate-sparing effects of SARM's makes them a useful and safe drug. It's crazy to hear someone running multiple grams of gear calling something like RAD-140 unsafe.

My 2c is that one would probably get great results running TRT-level test + RAD-140

 

[m314]

As a pharmacist, I gotta admit, I'm amazed by some of the ignorance in this thread. SARM's are any drugs that have differential effect on the various AR-expressing tissues. Trestolone (MENT) is a well known SARM with a steroid structure. YK11 is a less tested, but similarly steroid-structure SARM. To dismiss the non-steroid SARM's are somehow inferior out of hand is silly. All drugs exist on a spectrum, and they can range from unsafe (DNP, cardarine, etc), probably not great for you (clenbuterol, YK11), to reasonably safe (trestolone, RAD-140).

Without a doubt, the prostate-sparing effects of SARM's makes them a useful and safe drug. It's crazy to hear someone running multiple grams of gear calling something like RAD-140 unsafe.

My 2c is that one would probably get great results running TRT-level test + RAD-140

I haven't heard of this definition of SARM before. Trestolone is a SARM? Are trenbolone and nandrolone SARMs too? Those are the closest relatives to trestolone that are commonly used. What makes a compound a SARM, anything that's more anabolic than androgenic?

I didn't say RAD140 is unsafe. I said it made me feel irritated and angry all day. I don't get this side effect from any anabolic steroid other than tren. I'm a low dose guy, though. I've never come close to doing multiple grams in a week.

I also don't dismiss a class of compounds out of hand. I've seen hundreds of posts saying trestolone sucks because their favorite bodybuilder didn't need it. The people who said that didn't actually try trestolone.

I have not personally tried a non steroidal SARM that I liked. I will probably try more in the future.

 

[MisterSuperGod]

The poster boy for SARMs. Nuff said!

 

[rfan2020]

creatine poppers and androfiz are better than steroids too

 

[Silentlemon1011]

As a pharmacist, I gotta admit, I'm amazed by some of the ignorance in this thread. SARM's are any drugs that have differential effect on the various AR-expressing tissues. Trestolone (MENT) is a well known SARM with a steroid structure. YK11 is a less tested, but similarly steroid-structure SARM. To dismiss the non-steroid SARM's are somehow inferior out of hand is silly. All drugs exist on a spectrum, and they can range from unsafe (DNP, cardarine, etc), probably not great for you (clenbuterol, YK11), to reasonably safe (trestolone, RAD-140).

Without a doubt, the prostate-sparing effects of SARM's makes them a useful and safe drug. It's crazy to hear someone running multiple grams of gear calling something like RAD-140 unsafe.

My 2c is that one would probably get great results running TRT-level test + RAD-140

As a pharmacist (You)
I'm surprised you would recomend using an untested drug.

Of which we have ZERO idea what long term side effects are.
As for the prostate effects, pure bro science right now.

One study, said "This looks cool... we should follow up on this"
and all of a sudden everyone thinks it's a prostate agonist.

That would be like saying cocaine burns fat, it doesnt... it just kills appetite, we do not know WHY sarms do what they do with the prostate... so let's not pretend we do please.

 

[MFAAS]

I haven't heard of this definition of SARM before. Trestolone is a SARM? Are trenbolone and nandrolone SARMs too? Those are the closest relatives to trestolone that are commonly used. What makes a compound a SARM, anything that's more anabolic than androgenic?

I didn't say RAD140 is unsafe. I said it made me feel irritated and angry all day. I don't get this side effect from any anabolic steroid other than tren. I'm a low dose guy, though. I've never come close to doing multiple grams in a week.

I also don't dismiss a class of compounds out of hand. I've seen hundreds of posts saying trestolone sucks because their favorite bodybuilder didn't need it. The people who said that didn't actually try trestolone.

I have not personally tried a non steroidal SARM that I liked. I will probably try more in the future.

I think the pharmacist was just confusing Trestolone (MENT, which is a 19-nor) and Testolone (RAD-140, which is actually a a SARM).

The pharmacists post is decent, but seems to lack real world knowledge about SARMs vs steroids, He said people would get great results running TRT + RAD-140. For many people, sure, they quite probably would. Those same people would also probably get much better results TRT + NPP, or Tren, Primo, or even just blasting test and taking some anavar. Really just all the same shit this community is already doing lol...

SARMs are pretty fascinating and amazing drugs for what they were designed for so far: preventing muscle wasting due to other illnesses, I do think they hold some great potential for possibly being good add-ons to real AAS cycles in the future. But right now Ostraine/LGD/RAD-140 just aren't all that great yet I have tried them all and they just don't even come CLOSE to real gear and often have shitty side effects too. You will get better results every single time just running a classic 500mg test cycle..

That said, NOBODY is dismissing an entire class of compounds here so I don't know where you go that idea. SARMs have a lot of potential and someday some SARMs might be the go-to substances for body builders or powerlifters. We don't know what the future will hold, but RIGHT NOW, SARMs are not as good as most AAS and we know less about the safety of them. Additionally some of them have weird and terrible side effects (I had INSANE RAD-140 insomnia, OMFG). Nobody is "writing off" SARMs as a complete failure, but anybody who says they are "steroids 2.0" or that they are better than the gear we already have available is just plain fooling themselves. Maybe someday though!!!

Personally I truly hope they continue heavily investing and researching into SARMs for a multitude of potential drug and disease applications!

 

[jwarr]

I'm bowing out here. The bro-science is too real. Lets at least google words like agonist and antagonist before using them. For anyone that is interested in refs.

Evidence of tissue selectivity in MENT, making it a SARM:

Evidence for Tissue Selectivity of the Synthetic Androgen 7α-Methyl-19-Nortestosterone in Hypogonadal Men

The potent synthetic androgen 7α-methyl-19-nortestosterone (MENT) is resistant to 5α-reductase but is a substrate for aromatase. It may therefore offer sel

academic.oup.com

Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators - PMC

Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable ...

www.ncbi.nlm.nih.gov

Evidence of prostate sparing effect in RAD-140 (which has demonstrated safety in a phase I trial):

[PDF] Selective Androgen Receptor Modulators (SARMs): | Semantic Scholar

The ability of SARMs to promote both muscle strength and bone mechanical strength constitutes a unique advantage over other therapies for osteoporosis, that only increase bone density. Selective Androgen Receptor Modulators (SARMs) were discovered in the late 1990’s.They may have an application...

pdfs.semanticscholar.org

 

[Silentlemon1011]

I'm bowing out here. The bro-science is too real. Lets at least google words like agonist and antagonist before using them. For anyone that is interested in refs.

Evidence of tissue selectivity in MENT, making it a SARM:

Evidence for Tissue Selectivity of the Synthetic Androgen 7α-Methyl-19-Nortestosterone in Hypogonadal Men

The potent synthetic androgen 7α-methyl-19-nortestosterone (MENT) is resistant to 5α-reductase but is a substrate for aromatase. It may therefore offer sel

academic.oup.com

Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators - PMC

Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable ...

www.ncbi.nlm.nih.gov

Evidence of prostate sparing effect in RAD-140 (which has demonstrated safety in a phase I trial):

[PDF] Selective Androgen Receptor Modulators (SARMs): | Semantic Scholar

The ability of SARMs to promote both muscle strength and bone mechanical strength constitutes a unique advantage over other therapies for osteoporosis, that only increase bone density. Selective Androgen Receptor Modulators (SARMs) were discovered in the late 1990’s.They may have an application...

pdfs.semanticscholar.org

That was only one of the study I was referring to.

Let's get something perfectly clear.

The one you posted is a PHASE ONE TRIAL ON RATS
Not human.
We are HUMANS not rats

As for its Prostate Agonist properties....
I guess the doctors are wrong eh?


You're also far behind in your research
There have been human studies on OTHER SARMs
In which they HYPOTHESIZE that they COULD act as a prostate agonist, but decided a specific follow up study is required

Furthernore, as for Rad140 that you are suggesting.... the current findings are that it is an ag list for BREAST CANCER CELLS.

and not appreciably for the Prostate

(From the study you posted, where is CLEARLY states that Rad140 is NOT used for that
It also clearly states the dosage required for muscle growth us LOWER than would be required for Rad140 to actually inflame the prostate, insinuating that Rad140 does enlarge (Other study was done on TRT plus Rad140 and saw inflamation)




This HUMAN cell study,CLEARLY states that it does NOT act as YOURE saying.



So yeah

Please curb your bioscience

 

[jwarr]

Jesus Christ man, there is no such thing as a Phase I trial in rats. That is called pre-clinical research. Here is the phase I trial (humans) of RAD-140. Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer - Full Text View - ClinicalTrials.gov

You clearly have no idea what you're talking about, so I will not be responding to any of your further comments. Feel free to read all the articles I posted, they support the prostate sparing effect of SARMs.

 

[Silentlemon1011]

Jesus Christ man, there is no such thing as a Phase I trial in rats. That is called pre-clinical research. Here is the phase I trial (humans) of RAD-140. Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer - Full Text View - ClinicalTrials.gov

You clearly have no idea what you're talking about, so I will not be responding to any of your further comments. Feel free to read all the articles I posted, they support the prostate sparing effect of SARMs.

I already quoted that one.
See above.

Usually I'm quite nice about discussions as we are all here to learn and grow.


But you're a fucking dick.

 

[Silentlemon1011]

Jesus Christ man, there is no such thing as a Phase I trial in rats. That is called pre-clinical research. Here is the phase I trial (humans) of RAD-140. Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer - Full Text View - ClinicalTrials.gov

You clearly have no idea what you're talking about, so I will not be responding to any of your further comments. Feel free to read all the articles I posted, they support the prostate sparing effect of SARMs.

From the one you posted.
PhAsE oNe TrIaL

 

[Silentlemon1011]

Dylan Gemelli
Is that you?

 

[Human_backhoe]

Sarms cure Aids bro. Only if you hoop them.

Dylan Gemelli
Is that you?

 

[shackleford]

As a pharmacist

Hi sym!

 

[grey]

Feel free to read all the articles I posted, they support the prostate sparing effect of SARMs.

You read fucking poorly.