Should hCG be kept frozen for later use?

Discussion in 'Steroid Forum' started by Michael Scally MD, Jun 26, 2013.

Can hCG be kept frozen for later use?

  1. Yes

    19 vote(s)
    46.3%
  2. No

    22 vote(s)
    53.7%
  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    As many know, hcg is an important part of treatment. Is it safe to freeze reconstituted hCG for later use.
     
    Millard Baker likes this.
  2. Iatola

    Iatola Member

    Good to know. Thanks Doc
     
  3. Iatola

    Iatola Member

    I initially misread that as a statement, the product of a quick read on an iPhone. Sorry Doc.

    This would be interesting to know, especially with higher concentration vials and a low dose schedule. You could potentially preload and freeze.
     
  4. nattydread

    nattydread Member

    I remember a while back people would do that with their IGF. Don't know if it would work with hcg. I'll keep checking in cause I would like to know the answer as well
     
  5. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Take the Poll!!!

    It is just a click. And, possibly very important.
     
  6. cobra500

    cobra500 Member

    It would be great if it could!
     
  7. mands

    mands Member AnabolicLab.com Supporter

    I don't believe it's recommended for stability reasons. BUT, the question Dr. Scally has presented it possibly could be done with success. Do I know how...? NOPE!!!

    mands
     
  8. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    As a corollary question, would you freeze reconstituted hGH for later use?

    Take The Poll!
     
  9. Pericles

    Pericles Member

    It is my understanding, and correct me if I am wrong, but freezing destroys reconstituted hcg.

    I made the mistake of putting it in the freezer a couple of times.

    The HCG I get from a compounding pharmacy says "do not freeze."
     
    Michael Scally MD likes this.
  10. cobra500

    cobra500 Member

    Couldn't we answer this by freezing some, letting out the then treating it on a pregnancy test? If I had any left I'd do that right now to see.
     
  11. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    No! In fact, even doing a specific quantitative assay would not be adequate. Do you know why?
     
  12. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    How big and complex is hcg v hGH?

    NUTROPIN (somatropin)
    NUTROPIN (SOMATROPIN) KIT [GENENTECH, INC.]

    Nutropin® [somatropin (rDNA origin) for injection] is a human growth hormone (hGH) produced by recombinant DNA technology. Nutropin has 191 amino acid residues and a molecular weight of 22,125 daltons. The amino acid sequence of the product is identical to that of pituitary derived human growth hormone.

    STABILITY AND STORAGE

    Before Reconstitution—Nutropin and Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), must be stored at 2–8°C/36–46°F (under refrigeration). Avoid freezing the vials of Nutropin and Bacteriostatic Water for Injection, USP (benzyl alcohol preserved). Expiration dates are stated on the labels.

    After Reconstitution—Vial contents are stable for 14 days when reconstituted with Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), and stored at 2–8°C/36–46°F (under refrigeration). Avoid freezing the reconstituted vial of Nutropin and the Bacteriostatic Water for Injection, USP (benzyl alcohol preserved).
     
    Millard Baker likes this.
  13. cobra500

    cobra500 Member

    I have no idea, but want to learn.
     
  14. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    An assay will show that which comes up within their limits, but not necessarily that which is bioactive. In order to see whether freezing is not harmful there would need to be clinical trials to test for bioactivity, serum testosterone levels. It would be easy to have immunologically active hcg that is NOT biologically active.
     
    Last edited: Jun 30, 2013
    Millard Baker likes this.
  15. Pericles

    Pericles Member

    Or, I could just read the big fat sticker from my pharmacy that says "DO NOT FREEZE"[:eek:)]
     
    Michael Scally MD likes this.
  16. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    What about a very similar drug (LH)! This should put to rest the notion that one can safely freeze hcg for later use. If you do, it is based upon NO evidence, contrary evidence, and at your own risk (and $$$).

    MENOPUR (follitropin and luteinizing hormone)
    MENOPUR (FOLLITROPIN AND LUTEINIZING HORMONE) KIT [FERRING PHARMACEUTICALS INC.]

    How should I store Menopur®? Store Menopur® in the refrigerator at 36º to 46ºF (2º to 8ºC), or at room temperature, 68º to 77º F (20º to 25ºC).

    DO NOT FREEZE. [Emphasis in CAPS mine]
     
    Millard Baker likes this.
  17. Prior to this poll, I was my belief that hCG could NOT be frozen - just based on the package insert. When you started the poll, I started to second guess that and did some searching. All the manufacturers data I looked at, as well as any pharmaceutical research I found, warned against freezing reconstituted hCG. I was unable to find any evidence showing freezing is acceptable..

    This is an important topic because it's generally accepted in the bro lore that freezing reconstituted hCG is okay. I looked at the bro lore to see if this was based on anything more than the usual personal opinion and anecdotes. Interestingly, I found much of the belief seems to stem from comments made by this Crisler character that was mentioned in the other thread. He claims to have been convinced by the data from some compounding pharmacy but the data cannot be published because it's "proprietary"... Un huh. :rolleyes:

    Given the less than stellar track record of most compounding pharmacies, I would be very apprehensive about taking their word over the big pharmaceutical companies with billions of dollars for R&D. Especially because their data is supposedly proprietary.

    Interesting topic.

    CBS
     
    Last edited: Jul 1, 2013
  18. mands

    mands Member AnabolicLab.com Supporter

    NO to your question, not your statement to take the poll ;)

    mands
     
    Michael Scally MD likes this.
  19. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    I think the evidence is not there to freeze hcg for later use without running the risk of decreasing effectiveness. Why take the chance for any decreased efficacy, especially since it is your BALLS.

    It would be nice (and easy) to test what freezing would do to hCG bioactivity. And, the end point must be bioactivity and NOT immunoactivity. As it would be a simple clinical trial, maybe someone will take the time to run.
     
    Blacken and Millard Baker like this.