I also posted this note in the Antidepressants thread which is sort of buried in the sea of stickys. Thanks. Which of the SSRI's is the least activating? I am told that Prozac will hype you up the most. I know that it was activating to me. Is Prozac known to be the biggest activator? Which one is known to have the least activating effect? Prozac, Zoloft, Paxil, Luvox, celexa, lexapro? I tried Paxil for a few days about 5 years ago and it seemed to make me feel slightly sedated. But a Doc told me it is just as activating as all the rest. Not from what I felt. I have talked with many people that have used Zoloft without any side effects at all. They said none at all. Men and women. They took anywhere from 25 to 150 mgs. Only one women told me that it made her a bit sleepless and dry mouth for 8 weeks than went away. Everyone said it was a godsend to them in term of how it helped them. Also is Buspar an alternative to SSRI's? Does it have the same clinical effects on depression/anxiety/panic/OCD that the main SSRI group has??? Someone told me that it won't activate you or make you anxious as the SSRI's because it only raises certain serotonin levels and not all. Whatever that means. Docs please.