My cortisol at night is above-range. I now have explanation for my night sweats, diminished appetitie (evening), and lowered thryoid function. My main problem has been SLEEP. I haven't had a memorable night of quality sleep in probably 2 years. Here are the results: Cortisol Morning.........6.6 (3.7-9.5) Cortisol Noon..............1.9 (1.2-3.0) Cortisol Evening..........2.1 (0.6-1.9) HIGH Cortisol Night...............1.8 (0.4-1.0) HIGH You guys that take Isocort/Cortef, are your levels high or low? I have a stressful job and it taxes my adrenals, would cortisol supplement be beneficial? I actually spoke to a very knowledgeable person regarding adrenal fatigue. She's a pharmacist at a compounding pharmacy. And she attended a conference on AF a few wks ago. She gave me a printout of some OTC remedies. We talked for about 15 minutes. It was nice talking to medical professional that actually knows about this stuff. To combat this problem, I'm taking Phosphatidylserine (lower cortisol) in latter part of afternoon. And L-Theanine (relax/anxiety reducer)in the evening after dinner. Right before bed, I'm taking Trazodone (help sleep). Any ideas? Would taking cortisol in day help lower levels at night? Would taking cortisol help "rest" adrenals and regulate out-of-whack pattern?