Testicular Morphology After the Abuse of Anabolic Steroids

Discussion in 'Steroid Post Cycle Therapy and ASIH Treatment' started by Michael Scally MD, Sep 4, 2018.

  1. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Testicular Morphology in Hypogonadotropic Hypogonadism After the Abuse of Anabolic Steroids

    Hypogonadism in men results from the failure of the testes to produce physiological levels of testosterone and a normal number of spermatozoa due to a disruption of the hypothalamic-pituitary-testicular axis.

    An example of secondary hypogonadism as a result of anabolic steroid abuse is presented with the case report of a man who committed suicide after a history of aggressive behavior and physical abuse of his wife.

    The weight of normally developed adult testis in Caucasian men is 21.6 ± 0.4 g (right testis) and 20 ± 0.4 g (left testis). The mean testicular diameter of the longest axis is 4.6 cm (range 3.6– 5.5 cm), the shortest is 2.6 cm (range 2.1–3.2 cm). The testicular volume is between 15 to 25 mL.

    As the model of measuring is not described, it is not known if the data include epididymis, ductus deferens and tunica vaginalis, but we assume that the testes were measured without the other parts which are usually sent together for a pathological biopsy examination.

    A low-specific immunochemical analysis revealed a very high level of total testosterone (serum 109.8 nmol/L; urine 81.2 nmol/L). A more accurate analysis confirmed an overdose of synthetic anabolic steroids.

    The autopsy revealed shrunken testicles, with more than 30% of parenchymatous sclerosis, absent spermatogenesis, and very few Leydig cells detected only by immunohistochemistry.

    The weight of the right testicle (without the epididymis, ductus deferens and tunica vaginalis) was 6.85 g, and the left testicle 6.66 g. The dimensions of the testicles in the longest and shortest axis were: 3.2 × 2.7 cm (right testis) and 3.0 × 2.9 cm (left testis).

    Macroscopically visible degenerative changes with sclerosis of more than 30%of the displayed cut surface in both formalin fixed testicles were apparent. The remaining parts were of adequate macroscopic morphology, but the histological examination revealed large areas of hyalinization and atrophy of the seminiferous tubules, with practically absent spermatogenesis. The tubular basement membranes were thickened, and the tubular lumina contained only Sertoli cells or were completely obliterated. Only rarely, singular Leydig cells were detected using immunohistochemistry for inhibin, melan A and calretinin.

    Alibegović A. Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids. Forensic Science, Medicine and Pathology 2018. Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids
  2. rpbb

    rpbb Member AnabolicLab.com Supporter

    what does the shrunken testes have to do with the guy killing himself
  3. Brandaddy

    Brandaddy Member

    I don't believe anything. I believe they were just explaining how the cadaver came about.
  4. G2Ready

    G2Ready Member

    Under the observation/impression that no stimulation of Leydig cells to make inter testicular testosterone would affect sperm morphology negatively.

    BUT Morphology would not be affected by high levels off TT by AAS given by injection.
    (At least not substantially)
  5. TRT@40

    TRT@40 Member

    Hi @G2Ready , do you have any papers on this? I would like to learn more about this.
    Sperm motility and count is greatly negatively affected by AAS taken by injection based on my sperm test. Unfortunately, during my last test, they did not test morphology.
    I am coming off cycle and starting proper pct to prepare for another baby...so relevant info be appreciated
    G2Ready likes this.
  6. G2Ready

    G2Ready Member

    Lol, I’m not quick at study and knowledge as @Millard Baker Is

    ... my observation/impression is what I noticed with myself.. and the few studies/articles I read — I was more using my statement as a observation that still needed a question mark?
    ^^^ I got a stack of info I used — I’ll see if I have anything you can use in your journey.

    What I meant by what I said was that
    AAS use of course effects motility and count because of the feedback loop and inter testicular testosterone protection is often nil Nada....

    While having high TT by AAS — with the supplementation of hcg & HMG I had fantastic motility and morphology —- not as high as count as pre AAS but quality was better.

    Good luck on adding another member to the family:)
    TRT@40 likes this.
  7. TRT@40

    TRT@40 Member

    Thanks fella for your reply.
    What was your hcg and HMG protocol?
    How much AAS you were on while taking hcg and hmg and you still had fantastic motility and morphology?

    I have a prescription for HCG so I would like to get just HMG instead the combo. Since you had a good success, would you please PM me where you sourced HMG from?

    Thanks again for sharing your positive experience!
  8. G2Ready

    G2Ready Member


    Coming off complete and using a doctor is by far best method...

    My docs wouldn’t even prescribe hcg or clomid....

    One said he would but I’d have to come off and wait up to a year before he would prescribe.

    Having children is something everyone should consider before starting trt — I was actually prescribed trt while questioning fertility with a urologist lol

    My fault of course but I did what I felt I needed to do

    Good luck
    kaizoku likes this.
  9. TRT@40

    TRT@40 Member

    That's an amazing experience you share! Good sperm numbers while on 500mg of test cyp. Did I read that right?
    We have one child before starting TRT. did not think at the time of starting TRT that we would want another.
    75IU of HMG 3x weekly is gonna run over a couple of grand; that is expensive! but nothing compared to IVF cost though.
    Thanks brother for sharing very useful info.
  10. G2Ready

    G2Ready Member

    *** sorry boss to get thread off topic

    Believe original discussion was intendeded for
    Testicular morphology
    Sperm quality

    Just got me thinking as I try and learn:)