TRT and Testosterone ShutDown

Discussion in 'Steroid Forum' started by Giza, Aug 7, 2018.

  1. Giza

    Giza Junior Member

    If you are on TRT/HRT for life (as in taking testosterone C, hcg, and Estrogen Blockers routinely) do you need to worry about the side effect of shutting down testosterone production from things like deca?
     
    Michael Scally MD likes this.
  2. brutus79

    brutus79 Member

    Um. The testosterone will shut down your normal production, and you can't shut it down while it's already shut down. You said trt for life so it wouldn't matter how long the deca takes to clear because the test will never clear on lifetime dosing.
     
  3. BIGSWEEZ

    BIGSWEEZ Member

    Just saw my DR yesterday and I'm medicated for life. I've been on trt 7 years he says it's too late for me. My testicles are the size of grapes, literally. So yes it will shut you down.
     
  4. Giza

    Giza Junior Member

    Thanks. Now I know I can kind of throw caution to the wind on the testosterone shut down side.
     
  5. Test_Subject

    Test_Subject Member

    You'll already be shut down from your TRT, so no.

    There are other side effects of deca worth considering, but shutdown isn't one of them, in your case.
     
    DrankSlangin likes this.
  6. Giza

    Giza Junior Member


    Since I'd be on testosterone and hcg would Deca Dick still be a worry?
     
  7. Test_Subject

    Test_Subject Member

    Hard to say. Nandrolone affects people differently. You'd have to try it and find out.
     
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  8. master.on

    master.on Member

    Theoretically you don't have to worry.

    But most people doing cycles, even heavy cycles
    can avoid permanent by using HCG during cycle, and bit into pct/off cycle.
    Most people jump into HRT without fully trying HCG for several months.

    Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.
    Coviello AD1, Matsumoto AM, Bremner WJ, Herbst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP.
    Author information

    Abstract
    In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum testosterone (T), suggesting that high ITT is needed relative to serum T for normal spermatogenesis in men. However, the quantitative relationship between ITT and spermatogenesis is not known. To begin to address this issue experimentally, we determined the dose-response relationship between human chorionic gonadotropin (hCG) and ITT to ascertain the minimum dose needed to maintain ITT in the normal range. Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk. ITT was assessed in testicular fluid obtained by percutaneous fine needle aspiration at baseline and at the end of treatment. Baseline serum T (14.1 nmol/liter) was 1.2% of ITT (1174 nmol/liter). LH and FSH were profoundly suppressed to 5% and 3% of baseline, respectively, and ITT was suppressed by 94% (1234 to 72 nmol/liter) in the T enanthate/placebo group. ITT increased linearly with increasing hCG dose (P < 0.001). Posttreatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group. These results demonstrate that relatively low dose hCG maintains ITT within the normal range in healthy men with gonadotropin suppression. Extensions of this study will allow determination of the ITT concentration threshold required to maintain

    Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression. - PubMed - NCBI
     
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  9. Theworm

    Theworm Member

    I think I get what the OP is trying to ask...

    When I’m on trt plus hcg my balls are full. When I add deca, my balls shrink. Maybe deca offsets the hcg? Maybe the progestins etc offset hcg working in the testes?
     
    TheBeat likes this.
  10. TheBeat

    TheBeat Member

    I can personally confirm is that hcg alone will maintain or bring back my sperm production while on anything except nandrolones/tren.
     
    master.on and NorthMich like this.
  11. Giza

    Giza Junior Member

    So even if I'm on permanent Test and HCG I will have some ball shrinkage and the possibility of Deca Dick. Any recommendations for a beginner cycle based on my situation of permanent Test, HCG, and E Blockers? (More focused on building mass right now compared to cutting down)