First it was Depo about two months ago. When my hemocrit levels raised when I went from 100mg to 125mg I was yanked off rather quickly - I have 25 stents and take Plavix so high hematocrit is off the table. I was on Testim in the past and never had an issue before I almost successfully completed a protocol to restart my own HPTA axis and did not follow through with another year of TRT before trying the protocol again - I have idiopathic hypogonadism and the testes, pituitary, and hypothalamus all responded to the protocol so they are working fine. But that is not what I am talking about here. I doubled my dose of Testim and my BP is about 145/95 and my cardiologist would like it no higher than about 125/85. I also noted my pulse rate is high - around 95, but both BP and pulse rate do drop during the day. The Depo was awesome at first, but then libido and erectile dysfunction hit and hit hard. I switched to Testim, got some arimidex (which I have yet to start at .25mg every third day), and do 250IU of hcg every three days. No real lab data on any of this yet. I know everyone is going to scream at me here for not starting the T, waiting, getting a measurement along with E2, then stepping up at the right time to arimidex (if necessary) and then on to HCG when everything is stabilized. I am going to do this when I return from my anniversary cruise. Right now, my libido and ED are normalizing to a point where I may be able to use a PDE5 inhibitor (Levitra is my choice). As my insurance does not cover Testim, when I return I am stopping everything and starting with 10g androgel, which it does cover and then taking the slow approach described above. I did not respond at all to 5g in the past, but on 5g of Testim I had morning numbers around 560 with one and only one measurement of 795 total T (I think this was an outlier). No gyno, no tender nipples, some water retention but not a great deal. Taking an HCTZ blood pressure pill (which is a diuretic) did not make that much of a difference. I am already on 10mg of Norvasc/day. I'm thinking cortisol caused by T being a little too high? Or maybe E2 being elevated but not enough to cause gyno, just enough to cause anxiety. My BP is tightly correlated to anxiety levels and I am on clonazepam to control this. I just want to make it through my anniversary cruise and be able to function sexually. After that, I have no problem with the slow methodical approach. I am just asking for some theories as to what the high BP, anxiety, and higher pulse rate MAY be caused by.