I have been reading this excellent forum for some time now and just joined. I will apologize in advance for my first post being so long. Some basic info I am 64 years old and had signs of low T starting about 2 years ago. I didn't think much of the mild ED and loss of strength, but then depression, mood swings and loss of libido started about 18 months ago. I did web searches for these symptoms and discovered that it sounded like low T, so I brought it up with my doctor at my next appointment. He agreed that is what it sounded like and tested my total T. Unfortunately he did not test all the other things like LH, FSH, E2, etc. Here is my history. I started to take 50 mg of DHEA daily February 2008. I have also taken 320 mg of saw Palmetto and 500 mg of nettle root extract for my BPH, which has helped the BPH a lot. I also take zinc, copper and a bunch of other vitamins and minerals. All tests at Quest except E2 at local lab. May 2008 DHEA-S = 450 (25-95 for age group) Seems like good place to be. Total T = 304 (250-1100) Low even though in lab range. Dr agreed that it should be at least 500 for someone my age and started me on androgel 5 gm. July 2008 Total T = 357 (250-1100) Still low Free T % = 2 (1.5-2.2) Free T = 69 (35-155) Lower than it should be. E2 = 25.6 (20-56) - Good Depression was better, but not much change in anything else. Upped Androgel to 7.5 gm. November 2008 DHEA-S = 617 (25-95 for age group) Too high. Total T 277 (250-1100) Not good at all. Free T % = 3 (1.5-2.2) E2 = 46.5 (20-56) Getting too high. I was feeling no better or even a little worse. I had read about Testim having better absorption, so I asked the Dr to switch me to Testim 10 gm. I also reduced DHEA to 25 mg and started to take 200 mg of Source Naturals DIM. February 2009 Total T 644 (250-1100) Things are looking up. I had been feeling better for a couple of months and my ED was better, but not gone as 2 years prior when I was 62. I had none until 2 years ago. Annual physical May 2009 DHEA-S = 232 (25-95 for age group) DHEA = 99 (61-1636) Total T = 862 (250-1100) Testim is really working. Free T = 179 (35-155) High. Free T % = 2 (1.5-2.2) E2 = 57.2 (20-56) Too high. DHT = 132 (25-75) Too high. So it seems like I need to lower my Free T and DHT and of course, try to get E2 into the 20-30 range. Here are the changes I have made: I think that the DHEA is converting to E2, so I have stopped taking DHEA. I have cut the Testim to 7.5 gm daily. I have added another 160 mg of saw palmetto to try to bring DHT down. I have added 6 mg of progesterone cream at night, as it is a 5 alpha reductase inhibitor and possibly a weak AI. I have stopped the Source Naturals DIM and started on one tablet of Indolplex DIM and 750 mg of TMG. I have been on this for just over 2 weeks now and ED is worse and libido is down. I guess I've screwed something up. My guess is the progesterone cream is at fault, as I tried that a few months ago and it hurt libido, so I stopped. Normally 25 mg of viagra would do wonders for the ED and 50 mg would bring me back to my younger years , but now neither seem to work. Any thoughts and suggestions would be greatly appreciated.