What’s the current state of generic GH

[Ghoul]

you are Verrry Thorough, gives me new stuff to "study" on hgh and all that's involved,,,

Thanks. The sum total of this, for those who care, is that whatever steps one is willing to take to control the factors we can to reduce immunogenicity has a payoff. Maybe small, maybe, in the long run, huge. I'm not calling anyone an idiot for failing to follow all the best practices. I certainly don't every time. But it's info worthy of being put out there and considered. Thats all. The health of randos, with a few exceptions, is of no concern to me.

I used to "show my work", but it's too much effort, most don't read it, fewer comprehend it. I'm always happy to go into more detail on request to help others learn, and the exercise benefits me as well. since it prompts me to update my knowledge with current research. But I guarantee you, if some clown wants to step up for a smackdown, I'm always well prepared for that too.

 

[Ateam2023]

Thanks. The sum total of this, for those who care, is that whatever steps one is willing to take to control the factors we can to reduce immunogenicity has a payoff. Maybe small, maybe, in the long run, huge. I'm not calling anyone an idiot for failing to follow all the best practices. I certainly don't every time. But it's info worthy of being put out there and considered. Thats all. The health of randos, with a few exceptions, is of no concern to me.

I used to "show my work", but it's too much effort, most don't read it, fewer comprehend it. I'm always happy to go into more detail on request to help others learn, and the exercise benefits me as well. since it prompts me to update my knowledge with current research. But I guarantee you, if some clown wants to step up for a smackdown, I'm always well prepared for that too.

Indeed, "gotta stay ready, so you don't have to get ready",,,,,

 

[songsofpyramids]

take to control the factors we can to reduce immunogenicity has a payoff

I will be filtering all my peptides from here out after reading the sources you’ve posted about it. I will even be filtering stuff from a compounding pharma, not just ugl as the information about aggregation has been that convincing and alarming to me. Thank you for sharing that information. I honestly think it’s likely some of the more important harm reduction shared for peptide users since I joined meso. I am currently shopping around for some good pes .22um filters and some vials.

 

[Ghoul]

Indeed, "gotta stay ready, so you don't have to get ready",,,,,

It's funny, I almost didn't bother posting about immunogenicity here, but I was reminded of the existence of "private testing groups" yesterday, and how much they irritate me.

I get it, you put in time and resources to have Jano do some comprehensive testing of one sort or another. The payoff from that is you get your specific questions answered, on your terms. But to then keep the results private, for no reason other than you can, strikes me as the worst kind of selfishness. There's simply nothing to gain from that, other than being able to hoard knowledge in order to stroke your ego.

What I share here isn't to preach (maybe a gentle "sell" of what I see as harm reduction), but I could save myself the trouble. I can handle a good faith disagreement, hell, I welcome it, but to straight up spit in my face in response to sharing what I've discovered is such uncalled for low class behavior that it can't go unresponded to.

 

[egruberman]

A photo of your Edward Green collection would suffice.

That’s a bigger ask than a $100 donation. I have two custom pairs, rarely worn, not in a shoe box and dusty as hell. I’d be embarrassed to take a photo without cleaning and polishing first.

West coast tech bro here. I’m presently wearing some Vivo barefoot sneakers.

 

[Ghoul]

That’s a bigger ask than a $100 donation. I have two custom pairs, rarely worn, not in a shoe box and dusty as hell. I’d be embarrassed to take a photo without cleaning and polishing first.

West coast tech bro here. I’m presently wearing some Vivo barefoot sneakers.

Feet just aren't meant to be confined. I stay in sandals or barefoot as much as possible, despite enjoying a high quality, bespoke shoe myself.

 

[Spaceman Spiff]

Who in the fuck takes a week to go through a vial of GH? Even the largest vial of GH only lasts 3 days TOPS in my fridge.

Spoiler: What's this?

Very serious, but, humor is the only intent.

"But online says to use 4iu a day, so I pull it to 4 on the syringe, it lasts me about 3 weeks"

 

[Benf15harp]

I haven’t paid for my own clothing or shoes …..ever
Guess I’m a poor.

 

[Black Beard]

Hey all,

So I know this is a constant point of discussion but I wanted to get some current takes from experienced members on generic GH.

I’ve heard advice from both ends of the spectrum. Save your money up and use pharma or don’t use it at all. And, that generics can yield comparable results and don’t blow your money on pharma GH.

For example I was looking at a product that was tested by jano and the price was right, but I always wonder if buying GH based on price is kind of like shopping for a heart surgeon based on price.

Here’s the testing and wanted to hear your thoughts. View attachment 306704

At the end of the day, generics raise IGF-1. That has benefits, period. Mainly anti-aging (maintaining body composition) and also benefits for cardiovascular system, and brain health among other things.


Cosmetically is up for debate, but many many many shredded/aesthetics/pro physiques are built on generics, and many competitors run generics all into show day.


Many members here have improved quality of life, recovery and other benefits from generics.

 

[Trenbolonetax]

"But online says to use 4iu a day, so I pull it to 4 on the syringe, it lasts me about 3 weeks"

Dude…if I had a nickel for every time I heard this… unfuckingbelieveable.

 

[Trenbolonetax]

That’s a bigger ask than a $100 donation. I have two custom pairs, rarely worn, not in a shoe box and dusty as hell. I’d be embarrassed to take a photo without cleaning and polishing first.

West coast tech bro here. I’m presently wearing some Vivo barefoot sneakers.

Your broken link makes complete sense now.

 

[bjjgear]

That’s a bigger ask than a $100 donation. I have two custom pairs, rarely worn, not in a shoe box and dusty as hell. I’d be embarrassed to take a photo without cleaning and polishing first.

West coast tech bro here. I’m presently wearing some Vivo barefoot sneakers.

Same with my Ferrari and beach house. Both way too dirty to show right now but I do have a picture of a one hundred dollar bill in my wallet.

 

[Trenbolonetax]

What the fuck are you talking about retard?

Let me demonstrate what resulted from your mother's poor decision making one night.

I don't like to go into the evidence too deeply because it's TLDR and I'm not here to educate idiots like you.

I'll make an exception for the benefit of others.

Patients on growth hormone are closely monitored for the expected progress and IGF levels while on treatment. If those aren't maintained, they're tested for anti-growth hormone antibodies, which result from an immunogenetic reaction to rHGH.

If high "titers" of anti-growth hormone antibodies are found, the options are:

-Increase the dose to overcome immunogenicity.

-Take a break and try again when (if) the level of antibodies goes down.

-Switch brands

-Stop treatment

Here's a table with the levels of antibodies in patients who's results weren't as expected. and the percentage of rHGH neutralized.

These reactions develop in response to high quality PHARMA formulations, not UGL trash, stored in uncontrolled temps, reconstituted to some random PH, into "patients" who aren't monitored for response or antibodies.

I'm sure that unlike pharma, UGL can't possibly induce the same loss of effectiveness right?

View attachment 306842

The patients who had the strongest immunogenic responses (The RIA number), 10,11, and 15, completely stopped responding to rHGH. This happened AFTER 10-23 months of daily rHGH injections. All were changed to another brand. 10 and 11 had no improvement and treatment failed entirely. 15 was able to continue with the new brand, immunogenicity was reduced, and growth resumed.

The other patients kept growing, but at a slower rate due to increased inhibition of rHGH.

So either I'm a crackpot, or you're the product of a crackwhore. For the sake of your mother's honor, I'm sure you'll be able to demolish this "theory" with your own evidence.


PS: The same anti-GH Antibody tests are available at walk in testing centers like Quest, for $269, in case anyone feels like GH isn't working like it used to and wants to know if this is the reason.

View attachment 306847

Okay. If you tell me my HGH might stop working you now seriously have my attention.

Fuck. TrenT is getting some filters and vials (oils and peps) for Christmas.

The gift that keeps on giving.

 

[bjjgear]

Feet just aren't meant to be confined. I stay in sandals or barefoot as much as possible, despite enjoying a high quality, bespoke shoe myself.

Same here tbh. My daily drivers are Adidas slides, even in the winter as I wear them with socks.

 

[Toaster]

What the fuck are you talking about retard?

Let me demonstrate what resulted from your mother's poor decision making one night.

I don't like to go into the evidence too deeply because it's TLDR and I'm not here to educate idiots like you.

I'll make an exception for the benefit of others.

Patients on growth hormone are closely monitored for the expected progress and IGF levels while on treatment. If those aren't maintained, they're tested for anti-growth hormone antibodies, which result from an immunogenetic reaction to rHGH.

If high "titers" of anti-growth hormone antibodies are found, the options are:

-Increase the dose to overcome immunogenicity.

-Take a break and try again when (if) the level of antibodies goes down.

-Switch brands

-Stop treatment

Here's a table with the levels of antibodies in patients who's results weren't as expected. and the percentage of rHGH neutralized.

These reactions develop in response to high quality PHARMA formulations, not UGL trash, stored in uncontrolled temps, reconstituted to some random PH, into "patients" who aren't monitored for response or antibodies.

I'm sure that unlike pharma, UGL can't possibly induce the same loss of effectiveness right?

View attachment 306842

The patients who had the strongest immunogenic responses (The RIA number), 10,11, and 15, completely stopped responding to rHGH. This happened AFTER 10-23 months of daily rHGH injections. All were changed to another brand. 10 and 11 had no improvement and treatment failed entirely. 15 was able to continue with the new brand, immunogenicity was reduced, and growth resumed.

The other patients kept growing, but at a slower rate due to increased inhibition of rHGH.

So either I'm a crackpot, or you're the product of a crackwhore. For the sake of your mother's honor, I'm sure you'll be able to demolish this "theory" with your own evidence.


PS: The same anti-GH Antibody tests are available at walk in testing centers like Quest, for $269, in case anyone feels like GH isn't working like it used to and wants to know if this is the reason.

View attachment 306847

I'm talking about you being a methed out crackpot who cherry picks data to confidently confirm his bias.

 

[Ateam2023]

It's funny, I almost didn't bother posting about immunogenicity here, but I was reminded of the existence of "private testing groups" yesterday, and how much they irritate me.

I get it, you put in time and resources to have Jano do some comprehensive testing of one sort or another. The payoff from that is you get your specific questions answered, on your terms. But to then keep the results private, for no reason other than you can, strikes me as the worst kind of selfishness. There's simply nothing to gain from that, other than being able to hoard knowledge in order to stroke your ego.

What I share here isn't to preach (maybe a gentle "sell" of what I see as harm reduction), but I could save myself the trouble. I can handle a good faith disagreement, hell, I welcome it, but to straight up spit in my face in response to sharing what I've discovered is such uncalled for low class behavior that it can't go unresponded to.

i didn't mean it as any Disrespect Ghoul , i am in total agreement of all you do for this forum , it makes more dilligent in my own "research" as you pose questions i wouldn't think of ,, Again i Respect "Everything" you post Ghoul so excuse the confusion on my part

 

[Ghoul]

i didn't mean it as any Disrespect Ghoul , i am in total agreement of all you do for this forum , it makes more dilligent in my own "research" as you pose questions i wouldn't think of ,,

Bro, I'm not talking about you. We're good. .