Discover the unique pharmacological effects of Dianabol (Metandienone), highlighting its potent estrogenic activity via undetectable aromatization, significant suppression of cortisol through ACTH inhibition, hypertensive properties, and pronounced suppression of natural testosterone. Essential insights for informed harm reduction and safe usage considerations.

DHB is a non-aromatizable, hepatotoxic anabolic steroid with unique metabolism to DHT. Known for severe post-injection pain and carcinogenic risks, it may also act as a weak 17β-HSD1 inhibitor, influencing estrogen balance.

Methasterone (Superdrol) is a potent anabolic steroid known for its impressive muscle-building properties and low androgenic effects. However, it is highly hepatotoxic, limiting its use to advanced bodybuilders during contest prep despite limited supporting data.

Oxandrolone (Anavar) is a mild anabolic steroid known for reducing abdominal fat, enhancing strength via creatine synthesis, and anticatabolic effects through AR-GR crosstalk. While well-tolerated, it poses dyslipidemic risks.

Nandrolone, an anabolic-androgenic steroid, promotes collagen synthesis, supports joint health, and enhances oxygenation and vascularity. However, it poses risks like cardiac hypertrophy, sexual dysfunction, and cognitive issues. It’s valued for muscle growth, joint support, and performance enhancement.

Testosterone is a unique anabolic steroid, essential for male sexual function, muscle growth, and insulin sensitivity. It amplifies and aromatizes, unlike other AAS, contributing to its critical role in male physiology and bodybuilding practices.

MENT (trestolone) is an anabolic steroid with potent estrogenic and progestagenic effects, causing gynecomastia, fluid retention, and increased blood pressure. It is unsuitable for bodybuilding purposes.

Fluoxymesterone (Halo) is a potent androgen used by bodybuilders and athletes for its strength-enhancing, fat-reducing, and muscle-hardening effects. It antagonizes glucocorticoid receptors, reduces fat mass, increases muscle mass, and has notable effects on mood and behavior.

Learn about Stanozolol’s unique features. It is distinguished by its pyrazole ring attachment enhancing its half-life and biological effects. It modulates glucocorticoids, increases free IGF-I, and antagonizes progesterone receptors. However, it causes joint pain and is hepatotoxic.

This is the first in an eleven-part series exploring the unique features of anabolic-androgenic steroids (AAS), starting with trenbolone. It examines its insulin-sensitizing, anabolic, and anticatabolic effects, and its impact on the cardiovascular system.