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You are here: Home / Anabolic Steroids and Performance-Enhancing Drugs / Deca Durabolin (Nandrolone Decanoate)

Deca Durabolin (Nandrolone Decanoate)

Andromedica Deca 250

Deca, also known as Deca Durabolin or nandrolone decanoate, is perhaps the second-best known injectable anabolic steroid after testosterone. It seems that almost every steroid novice and many who are experienced with steroid cycles believe that for best results they may need to include Deca. However, in fact this compound has no special anabolic properties: other injectable steroids can do everything for muscle growth that Deca can.

Popularity of Deca Durabolin

The unusual properties of Deca Durabolin are due to its parent steroid, nandrolone, also known as 19-nortestosterone. One of the principal positive qualities of nandrolone is that it has relatively low conversion to estrogen compared to testosterone.

In earlier years, testosterone and nandrolone were the only pharmaceutical injectables that were both widely available to bodybuilders and economical. Estrogen control did not then exist. For this reason, Deca’s low aromatizing properties were then quite useful. Deca therefore won wide popularity.

Deca Durabolin Effects on Hair and Skin

An additional advantage of Deca Durabolin (nandrolone) is that this compound is relatively mild in terms of adverse side effects on the scalp and skin. This is because the 5-alpha reductase enzyme acts to reduce the potency of nandrolone, while in contrast many other anabolic steroids are unaffected by this enzyme, and testosterone’s potency is actually increased by it.

Deca Durabolin and Joints

Further, where athletes have joint problems, in many instances use of Deca in a steroid cycle has the positive side effect of providing some aid. Even doses as low as 100 mg/week can entirely suffice for this purpose in many instances.

Deca Durabolin and Recovery of Testosterone Production

Unfortunately, Deca Durabolin usage very commonly has the adverse side effect of interfering with recovery of natural testosterone production after a steroid cycle. Adverse side effect on libido and/or erectile function is also common, but typically only when dosage is at least 200-400 mg/week or when the drug is used alone at any effective dose. Problems are worse when Deca is not combined with testosterone or substantial doses of more androgenic compounds such as trenbolone, Masteron, or Dianabol. There is wide individual variability in response with regard to side effects on libido and erectile function. Depression of mood is also possible.

Deca Durabolin Recommendations

For these reasons I generally recommend against Deca Durabolin use except where the athlete already knows that he can experience joint relief from the compound, or he wishes to see if that will be the case for him and he understands the possible adverse side effects. I prefer for Deca use to be as low as is effective for any such joint problems, and for the majority of the total steroid dosage to be from other compounds.

The long half-life of the drug results in slow clearance. For this reason, Deca Durabolin is unsuited to short cycles or where drug testing is a possibility. I also consider the drug a poor choice for women due to being at least as virilizing per milligram as most other anabolic steroids except testosterone and taking too long to clear if side-effects occur.

“Deca Durabolin” is a registered trademark belonging to Organon. Injectable steroid products are properly called this only when produced by Organon, but the name is often used for underground preparations as well. The Organon preparation is provided at 200 mg/mL.

Parapharma Deca Durabolin

About the author

Bill Roberts
Medicinal chemist

Bill Roberts is an internationally-recognized expert on anabolic steroids and performance-enhancing drugs (PEDs). He received a bachelor degree in Microbiology and Cell Science and completed the educational and research requirements for a PhD in Medicinal Chemistry at a major American university.

Bill entered the nutritional supplement industry prior to completing his doctoral thesis but his education was invaluable so far as being able to design/improve nutritional supplement compounds, since it was in the field of designing drug molecules and secondarily some work in transdermal delivery.

His education was not specifically "geared" toward anabolic steroids other than expertise with pharmacological principles having broad applications. This has allowed Bill to provide unique insight into the field of anabolic pharmacology with knowledge of points which he would not have known otherwise.

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Avatar of Ankle pick Ankle pick Apr 10, 2022 #1

Hey so who has any exponent experience with Deca as it relates to rebuilding rejuvenating joints I’ve been through orthopedic hell and was attracted to HGH for this I know Anabar can help with tendons and stuff sometimes budeca seems the best,
I’m gonna run a TRT dose of test E (200-250) with 4ius EOD of optitropin. I was looking for a kick starter bulker but deca is interesting Because of the joint help
What are you guys think 10200 mg data on top of the HEH and test?

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b broskii88 Jun 12, 2022 #2

bumping because I too am adding deca for joint relief. im currently on 3iu daily of generic gh for 45 days so far and although its working for my skin/nails/sleep it hasn't done shit for my aching body yet and even caused me to re-injure by pushing myself too hard because it gives a boost to me mentally. can anyone chime in with how long it takes for deca to start working on the joints once its in my system?

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b broskii88 Jun 12, 2022 #3

well thats strange. all the literature suggests nandrolone is good for the joints, and a quick search turned up tons of anecdotes about dbol causing joint pain. we all truly respond differently huh? I'll have my hands on a 300/ml vial of deca on Monday, and figured id start with 75mg a week along with my 175 trt. Praying for instant relief but these things take time.

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Avatar of lukiss96 lukiss96 Jun 12, 2022 #4

Deca better left alone cuz bicycle riders once you crash your bike (come off/pct time) you are gonna make it hard for yourself. Unfortunately it's one of the most available and popular steroids, so guys just naturally think deca as big gains and don't care about the consequences much. Younger ones especially.

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Avatar of Iamnatty Iamnatty Jun 12, 2022 #5

What you mean. I don't get what your saying here

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Avatar of lukiss96 lukiss96 Jun 12, 2022 #6

Basically the guys that cycle and then pct and I think they shouldn't do deca.

Here's why: deca is a long decanoate ester (~14-15 days half life), now say someone took deca at 600mg for 12 weeks with frontload like it's popular in forums.

Long half life means long clearance of the drug, so 14-15 days later in this case we still have 300mg and a month later we still have 150mg and after month and a half still 75mg and on...

See deca is suppressive even at small dosages, so your planned pct therefore must be 8-10 weeks after stopping this drug, which makes it inconvenient and hard to recover for cycle & pct guys, especially newbies.

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Avatar of Clyde Clyde Jun 12, 2022 #7

There's always NPP for a shorter ester nandrolone.

Still doesn't change potential larger issues getting HPTA back on line after 19-nor usage compared to other AAS from what I understand.

I believe all the 19-nors would make it much more challenging to restore endogenous T production, regardless of the PCT protocol used.

Agree with you that deca (and other 19-nors) are probably best avoided for anyone cycling gear.

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Avatar of canadian mutant canadian mutant Jun 12, 2022 #8

It helps my joints a lot, nandrolone is by far my fav PED. It takes a while tho, deca is a long ester, takes longer to kick in then other PEDs

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b broskii88 Jun 12, 2022 #9

thanks for the info. I was hoping there would be some quick relief with deca so I dont have to take it easy. Perhaps I should have gone with NPP. Either way, just going to have to tough it out for a few weeks and hope the hgh and deca provide some synergistic relief in the long run. Sometimes I feel like the HGH made things worse with the joints but could be my imagination.

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T The_Dane Jun 16, 2022 #10

Clinic talked me into deca over anavar. Beside learning to not waste my money at a clinic for any reason than legally being on tons of test, I learned I have the worst fucking reactions to deca and the hell that is coming off of it. This shit rocked me mentally.

I hated myself and everyone, I wanted to fuck everyone, I wanted to cry, if my girl wasn't getting dicked daily she wouldn't have dealt with my ass, I thought she was cheating on me with this bone skinny queer dude at work who cant even maintain eye contact. Not to mention the headaches. I only took it for 7 weeks because of the sides, I have no idea how guys with sides put up with this shit for a whole cycle.

I wish I was exagerating this but I never plan to touch this shit again. the gains were so minimal for the amount of bullshit my head went through.

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Avatar of Iamnatty Iamnatty Jun 16, 2022 #11

It's crazy how it effects people different. I had simular experience. It'd been a year I was gonna try it again and see if any different lol

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Avatar of lukiss96 lukiss96 Jun 16, 2022 #12

Don't, if you got bad reaction chances are your body is gonna hate you for doing this again. If you really wish to "try it again" do npp, but in my experience if you don't get along with 19nors first time then you never will. Take it as you want, I dislike 19nors and so does my body I never enjoyed any of them no matter how low dose I did and how different I approached it. After years of playing around, I know I do good on testosterone and it's closest derivatives and only some dhts.

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Avatar of Theworm Theworm Jul 16, 2022 #13

I think I started seeing gains at week 8-10… how about you?

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Avatar of Broskie Broskie Jan 25, 2023 #14

Please mention or make note of the safety profile for Deca.

The joint "lubricating" effects are attributed to the LARGE increase in collagen production this compound promotes.

COLLAGEN IS CONTRIBUTORY TO BLOOD VESSEL CALCIFICATION.

You should be EXPECTING this to be quite harsh on the development of plaque, especially at middle ages and older.

Please keep this in mind. If you come from a family with a history of blood clots, heart attacks, or other cardiovascular disease, this drug WILL push you closer to the development of these issues QUICKER than most any other steroid at the typicall "bodybuilding" doses. I would keep STRONGLY reccomend keeping this compound in the 200-450mg range and treat is as an accessory compound and not the compound you are relying on heavily for mass should you be prone to cardiovascular diseases.

No steroid comes for FREE and this is one of Deca's BIGGEST downsides second to the proported neuro-toxicity of 19-NOR compounds.

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W Whopperflopper Jan 26, 2023 #15

Hmm, last spring I suffered a knee injury and added Deca and Hgh to my Trt dose to help heal.

After a month or so, my calf swelled even more. Woke up one morning, ran out breath trying to tie shoes. At ER, found out I had a blood clot from ankle to groin and a piece had traveled to my lungs.

I'm only 50, no family history, great labs to this point.

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Avatar of Theworm Theworm Apr 30, 2023 #16

That’s scary!

I used to use a lot of nandrolone cause I was always worried about my hair. But the more I read it seems to be harsh on vascular endothelial cells and the heart.
@Type-IIx any thoughts on this toxic aspect of nandrolone? There’s that infamous study that showed the compound to be 11x more damaging on the vascular endothelial cells than testosterone (study was on rats though)…

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