Mr. Haycock, I consider myself well versed on steroids and how they work, but one thing that continually has me puzzled is this; if there is only one androgen receptor that all steroids bind to in order to induce growth, how come there are so many diverse effects of different synthetic steroids. Some make you […]
Using Growth Hormone? One New Drug May Make It More Effective
Effects of Troglitazone on hepatic and peripheral insulin resistance induced by growth hormone excess in rats. Researchers: mm,Sugimoto M, Takeda N, Nakashima K, Okumura S, Takami K, Yoshino K, Hattori J, Ishimori M, Takami R, Sasaki A, Yasuda KThird Department of Internal Medicine, Gifu University School of Medicine, Japan.Source: Metabolism 1998 Jul;47(7):783-787 Summary: The purpose of the present […]
Androgen Receptors Downregulate Don’t They? Part 2
In part 1 of this article we discussed the mistake of thinking about androgen receptors (testosterone receptors) in the same way we think of other receptors such as beta-receptors. Beta-receptors down regulate in response to beta-adrenergic stimulation whereas there is good evidence that androgen receptors increase in numbers in response to androgens. We also discussed […]
Androgen Receptors Downregulate Don’t They? Part 1
There is as much misinformation about steroids as there is good information had among bodybuilding enthusiasts. Go to any gym and you will hear some kid spouting off to his buddies about how steroids do this, or how they do that, or whatever. This soon starts somewhat of a pissing contest (excuse the expression) as […]
Prostaglandin PGF2a
Prostaglandins are part of a class of substances called eicosanoids. Eicosanoids are a group of substances derived from fatty acids and include prostaglandins, thromboxanes, and leukotrienes, all of which are formed from precursor fatty acids by the incorporation of oxygen atoms into the fatty acid chains. This reaction is called oxygenation and is carried out […]
Testosterone – The Good, the Bad, the Ugly
One of the most infamous hormones around is Testosterone. You hear Clueless news anchors about it on the evening news. You hear about it in the gym. You even read about it in the “growing older with style” magazines. Depending on who you talk to, it is both the good, the bad, and the ugly […]
Post Exercise Nutrition to Maximize the Training Effect
Introduction All too often athletes are looking for a food or diet that will increase their performance “during competition”. This is a misguided approach. The key role for nutritional intervention is during the training period. Nutrition will have the greatest impact on “performance” if it is used as an adaptive facilitator after appropriately periodized training […]
Are Steroids Your Key to Preventing Andropause?
Long-term suppression of leydig cell steroidogenesis prevents leydig cell aging Researchers: Chen H, Zirkin BR Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. Source: Proc Natl Acad Sci U S A 1999 Dec 21;96(26):14877-81 Summary: Based […]
Shooting Blanks? It May Be the Tamoxifen
Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata). Researchers: Rao AJ, Ramachandra SG, Ramesh V, Krishnamurthy HN, Jayaraman S, Gopalakrishnan K, Juneja HS Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India. Source: Andrologia 1998 May-Jun;30(3):129-32 Summary: Administration of Tamoxifen via the Alzet pump at […]
Oxandrolone Offers Relief to Spinal Cord Injury Patients
Treatment with an anabolic agent is associated with improvement in respiratory function in persons with tetraplegia: A pilot study.Researchers:Spungen AM., Grimm DR., Strakhan M., Pizzolato PM., & Bauman WA. Work originated at Spinal Cord Damage Research Center, Mount Sinai School of Medicine, New York, NY; and Medicine and Spinal Cord Injury Services, Veterans Affairs Medical […]