I trained with a couple sheriff deputies about 10 years ago. I supplied their gear. I also knew a US Marshall who used peds. I feel that I could have counted on a call if they ever caught wind of an investigation by LE. Not all cops are pricks.
MESO-Rx
Anabolic Steroids
So my weed days are done. Who can relate.
- Thread starter Mdrock98
- Start date
Mdrock98
Member
Lol
That’s all you have to say? So much shit to talk to big Paul and all you can muster up for me is a measly “lol” ? Fucking lame..
edit: thanks for quoting me though, I’m actually pretty proud I’ve cut back so much, I feel much better too physically having reduced my intake so much!
Mdrock98
Member
Here you go for "medical backround"It’s also used in a number is seizure disorders and some nerve disorders where the patients can’t even fucking move properly without smoking a joint, now tell us some more about your medical background so you can keep telling us how it has no medical uses? Would love to hear it
Conclusion
There is insufficient evidence to form a reliable conclusion regarding the efficacy of marijuana as an antiepileptic agent. Despite case reports demonstrating efficacy in reducing seizure frequency and severity, limited clinical studies have been published on its use for this indication. Additionally, the studies conducted were inadequately powered, lacked complete information, and used small sample sizes. There are few studies of long-term administration of cannabis and its safety profile. Currently, legal restrictions on cannabis make it difficult to conduct large-scale clinical trials, as the FDA has classified marijuana as a Schedule I controlled substance. The utility of marijuana for the therapeutic treatment of epilepsy cannot be determined at this time; more large-scale studies are needed that assess the efficacy and safety of treatment with either high CBD-THC ratio marijuana or isolated CBD compounds.
REFERENCES
1. Chang BS, Lowenstein DH. Epilepsy. N Engl J Med. 2003;349:1257-1266.
2. Marson A, Jacoby A, Johnson A, et al. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet. 2005;365:2007-2013.
3. Berg AT. Risk of recurrence after a first unprovoked seizure. Epilepsia. 2008;49(suppl 1):13-18.
4. Gloss D, Vickrey B. Cannabinoids for epilepsy. Cochrane Database Syst Rev. 2014;(3):CD009270.
5. Hill TD, Cascio MG, Romano B, et al. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. Br J Pharmacol. 2013;170:679-692.
6. Devinsky O, Cilio MR, Cross H, et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia. 2014;55:791-802.
7. Maa E, Figi P. The case for medical marijuana in epilepsy. Epilepsia. 2014;55:783-786.
8. Watson SJ, Benson JA Jr, Joy JE. Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Arch Gen Psychiatry. 2000;57:547-552.
9. Cilio MR, Thiele EA, Devinsky O. The case for assessing cannabidiol in epilepsy. Epilepsia. 2014;55:787-790.
10. Hill AJ, Williams CM, Whalley BJ, Stephens GJ. Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacol Ther. 2012;133:79-97.
11. Hawksworth G, McArdle K. Metabolism and pharmacokinetics of cannabinoids. In: Whittle BA, Guy GW, Robson PJ, eds. Medicinal Uses of Cannabis and Cannabinoids. London, England: Pharmaceutical Press; 2004:205-228.
12. Lodzki M, Godin B, Rakou L, et al. Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. J Control Release. 2003;93:377-387.
13. Mechoulam R. Marihuana chemistry. Science. 1970;168:1159-1166.
14. Cunha JM, Carlini EA, Pereira AE, et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology. 1980;21:175-185.
15. Trembly B, Sherman M. Double-blind clinical study of cannabidiol as a secondary anticonvulsant. Paper presented at: Marijuana ’90 International Conference on Cannabis and Cannabinoids; July 8-11, 1990; Kolympari, Crete.
16. Ames FR, Cridland S. Anticonvulsant effect of cannabidiol. S Afr Med J. 1986;69:14.
17. Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy Behav. 2013;29:574-577.
18. Hegde M, Santos-Sanchez C, Hess CP, et al. Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. Epilepsy Behav. 2012;25:563-566.
19. Volkow ND, Baler RD, Compton WM, Weiss SR. Adverse health effects of marijuana use. N Engl J Med. 2014;370:2219-2227.
20. Bergamaschi MM, Queiroz RH, Zuardi AW, Crippa JA. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011;6:237-249.
21. ProCon.org. Legal medical marijuana states and DC. Legal Medical Marijuana States and DC - Medical Marijuana - ProCon.org. Accessed September 9, 2014.
22. FDA. FDA and marijuana. www.fda.gov/NewsEvents/PublicHealthFocus/ucm421163.htm. Accessed December 3, 2014.
Mdrock98
Member
Here you go genius.
Is marijuana helpful in the treatment of epilepsy?
Epilepsy is a common neurological disease that affects 1 in 26 people at any point in their lifetime. Today more than three million Americans, including almost 400,000 children, live with epilepsy, with one-third living with treatment-resistant seizures.
The recent stories we hear about the children who have had positive outcomes from the marijuana derivative, cannabidiol (CBD), give reason for hope and should encourage further studies.
However, any treatment decision must involve an assessment of benefit versus risk. Although some cases reported in the media suggest potential for benefit, pediatric neurologists at Children's Colorado have also seen a number of cases where CBD has had no or minimal positive effect. In some instances CBD treatment has been associated with a worsening of seizures or other serious side effects leading children to be hospitalized.
Recent statistics in epilepsy treatment
Of the more than 75 children with epilepsy who we have seen who reportedly have received a marijuana derivative for treatment of seizures, only approximately 1 in 3 have shown any improvement in their seizures based on parental reports. It is important to note that none of these improvements has been confirmed when objective testing by EEG—which records electrical signals from the brain—has been performed.
More medical marijuana research is needed
This substantial gap between the various anecdotal reports underscores the desperate need for robust scientific evidence for the potential benefit and risks of marijuana in people with epilepsy. Healthcare professionals do not currently know if marijuana is a safe and effective treatment for epilepsy, nor do we know the long-term effects that marijuana will have on learning, memory and behavior, especially in infants and young children.
However, we do know, based on both clinical data in adolescents and adults, and laboratory data in animals, that there are potential negative effects of marijuana on these critical brain functions.
Every case of epilepsy is different and the disease itself is highly variable. Certain treatments that are effective for one type of epilepsy can be ineffective for or even worsen other types of epilepsy. Scientific studies in people with epilepsy help us to understand how and why various treatments work, and for whom they are effective. Research also helps us understand the correct dose, side effects and potential interactions with other medications.
The research needed to determine if marijuana derivatives are safe and effective for the treatment of children or adults with epilepsy cannot occur without funding. At the present time it is difficult, if not impossible, to obtain federal funding to complete research on medical marijuana due to the designation of marijuana as a DEA schedule 1 drug.
It is imperative that these studies be performed by medical researchers who have expertise in pediatric epilepsy and know how to conduct clinical research studies. It's also critical that these investigators have no financial interest in the results of these studies, so that the public can have the utmost confidence that the resulting findings are valid and unbiased.
Physicians and patients and their families need all the necessary information to make the best decisions regarding care.
Just means there’s a lack of real trials, that’s like saying trenbelone doesn’t work because there’s been a clear lack of human trials despite real world shown efficacy.
Did I say epilepsy ? I said A NUMBER OF SEIZURE DISORDERS, epilepsy is only one, genius.. also what you posted essentially says in the case of epilepsy 1/3 showed improvement, and that more medical testing is needed..
Mdrock98
Member
Mdrock98
Member
Mdrock98
Member
Again. Genius. No quality supporting evidence. Your addiction is justifying its "medical uses" when it's "medical uses" has no solid foundation. Period
Mdrock98
Member
My man.
WHAT THE RESEARCH SUGGESTS
THC and CBD can be useful in blocking pain associated with various medical conditions. These chemicals bind with receptors in your brain, blocking the transmission of pain signals. However, CBD also binds to more than just pain receptors and affects other signaling systems in your brain.
Years of research suggests CBD does have benefits for patients who experience epileptic seizures, although the impact is not entirely understood. The US Food and Drug Administration (FDA) approved the first CBD medication for seizure treatment in 2018. The medication, Epidiolex, was authorized for the treatment of two rare forms of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome.
Genius. The only approved medication is "Epidiolex"
Not "a joint"
[emoji38][emoji1787]lol [emoji38][emoji23]
Mdrock98
Member
Bro. I agree. Good form.
Mdrock98
Member
Lol. Both are pills. Not "joints", "bowls", or "blunts"
Lmfao.
How to use Nabilone Capsule
See also Side Effects section.
Read the Patient Information Leaflet if available from your pharmacist before you start taking nabilone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 2 to 3 times a day. The first dose may be taken the night before chemotherapy treatment. On the day you start chemotherapy, take nabilone 1 to 3 hours before chemotherapy begins. Continue to take this medication as directed by your doctor throughout your chemotherapy treatment cycle. Your doctor may also direct you to continue taking this medication until 24 to 48 hours after your treatment cycle ends. Follow your doctor's instructions carefully.
The dosage is based on your medical condition and response to treatment.
Marinol Dosage
Medically reviewed by Drugs.com. Last updated on March 28, 2021.
Generic name: DRONABINOL 2.5mg
Dosage form: capsule
Anorexia Associated with Weight Loss in Adult Patients with AIDS
Starting Dosage
The recommended adult starting dosage of MARINOL is 2.5 mg orally twice daily, one hour before lunch and dinner.
In elderly patients or patients unable to tolerate 2.5 mg twice daily, consider initiating MARINOL at 2.5 mg once daily one hour before dinner or at bedtime to reduce the risk of central nervous system (CNS) symptoms [see Use in Specific Populations (8.5)].
Dosing later in the day may reduce the frequency of CNS adverse reactions. CNS adverse reactions are dose-related [see Warnings and Precautions (5.1)]; therefore monitor patients and reduce the dosage as needed. If CNS adverse reactions of feeling high, dizziness, confusion, and somnolence occur, they usually resolve in 1 to 3 days and usually do not require dosage reduction. If CNS adverse reactions are severe or persistent, reduce the dosage to 2.5 mg in the evening or at bedtime.
Mdrock98
Member
Actually, you don't know as much as you think and those medical pills you listed are not "medical marijuana"
Spare me your bullshit
Spare me your bullshit
Mdrock98
Member
Actually you don't know as much as you think. Those medications you listed is not "medical marijuana"
Spare me your bullshit.
Spare me your bullshit.
They’re fda approved synthetic canaboids, either way I retracted my comment because I see that you’re still stuck on the topic of epilepsy for whatever reason... I know they’re not medical marijuana, and in Canada we have much better access to medical marijuana for a plethora of ailments. I choose not to take the nabilone because it’s almost like its too strong, when compared to actual flower I don’t feel like how strong the nabilone is.
Mdrock98
Member
Right. Indeed they are. Please read some of posts earlier. Those medications that you listed are indeed the only approved "cannabidiol" medication that has valid scientific evidence supporting its claim.
Marinol
Medically reviewed by Drugs.com. Last updated on March 28, 2021.
Generic name: DRONABINOL 2.5mg
Dosage form: capsule
Anorexia Associated with Weight Loss in Adult Patients with AIDS
And
This medication is used to treat severe nausea and vomiting caused by cancer drug treatment (chemotherapy). Nabilone is a man-made drug similar to the natural substances found in marijuana (cannabis). It is works by decreasing the signals in the brain that lead to nausea and vomiting.
You see genius. I specifically wrote those conditions earlier. Again, not "joints"
The "plethora of alignments" your talking about is, still hypothetical bullshit with unconclusive evidence supporting its validity of medical use.
Wow dude.
"plethora of alignments"
Sounds like you pulled that off Wikipedia..
So I have neither cancer nor nausea and I have a prescription for nabilone, so you see how that information above applies to very specific situations, yet it’s used for more than what the wiki page you copied that from says? Anyways you make valid points, but many of them are again, very case specific like the epilepsy ones you posted, true, but limited to few isolated and Recorded incidents, there’s plenty that doesn’t make its way into tease arch papers until it’s actually you know.. researched, but it would be fair to say that this shit needs more medical exploration, or maybe you feel it doesn’t, either way it’s valid as opinion, but to say medical marijuana is useless, unfounded and has no space with the context of your argument when everything points to needs more medical exploration and clinical data just seems wrong..
Mdrock98
Member
Right. You are prescribed nabilobe, not "joints" or "flower" What I'm saying, it's over hyped as medication, (as of now) it is more or ao along the lines of alcohol. With that being said, I think it should be legal, but I also see the consequences it can cause, due to personal experience, just as alcohol.
