I'd like to chime in on that. A while ago I complained about a vendor's orals, that there was no noticable effect (Jano test was good). People who fap to a Jano tests, told me to test it. Everybody's different, I get it. Nonetheless I do not see the point testing when there is literally zero benefit. The vendor won't change factory's production process anyway.
So let's take a look at other points than active ingredient here and this is where I just want to say "Fe3Lz RePoRt" might be not just for retards. This is by ChatGPT, I know some people here are smarter, they can ignore that post.
1. Formulation & Manufacturing Errors
- No protective matrix or coating: Without enteric coating or matrix protection, the compound may degrade in the stomach or even before ingestion is complete.
- Lack of micronization: If the raw powder isn't finely ground (micronized), it won’t dissolve efficiently in the gut → minimal absorption.
- No lipid-based carrier: These steroids are lipophilic (fat-soluble), and without fat or oil in the formulation, their absorption is significantly impaired.
- Inappropriate excipients: Certain fillers like talc, dicalcium phosphate, or poorly chosen binders can hinder proper disintegration or absorption.
2. Issues with the Active Ingredient
- Improper synthesis: If the molecule is not correctly synthesized, it may be chemically inactive or unstable.
- Degradation from poor storage: Light, heat, air, or moisture can oxidize or denature the compound, making it ineffective.
- Adulteration or dilution: The presence of bulking agents or impurities reduces actual dose and potency.
3. Bioavailability Problems
- First-pass liver metabolism: If the compound isn’t formulated to resist heavy hepatic breakdown, it may be almost entirely metabolized before reaching circulation.
- Incorrect pH exposure: Steroids require a certain pH to remain stable; if exposed to unfavorable pH without buffering, they may degrade.
- No protection against enzymatic breakdown: Some substances are sensitive to enzymes in the digestive tract and need protection to remain active.
4. Red Flag: Tablets Dissolve Too Quickly (e.g., in the mouth)
- This often indicates low compression pressure or weak binders used during tableting.
- Rapid disintegration is unsuitable for lipophilic steroids → loss of active ingredient before proper absorption.
- Suggests poor formulation design and likely poor systemic delivery.
5. What Would a Proper Tablet Require?
- Finely micronized and stable active compound.
- Lipid-based delivery (e.g., with MCT oil or lecithin).
- Adequate binding and timed disintegration—not too fast, not too slow.
- Optional: enteric coating or pH-sensitive matrix to bypass stomach degradation.