Reta vs Tirz

[seelos]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

 

[BP_6]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

I had the same decision a while ago. I would have likely been happy with whatever route I chose and there is no real wrong choice. I did however personally choose Triz for the following reasons that at least for me gave it a small edge.

1. A bit less expensive
2. Much more data and much better tested and proven
3. I don't want my RHR to be much faster than it already can be.
4. The three receptor all in sounds really good. However as with all things there are sacrifices. The more different receptors you try to hit you have to generally give up a bit on other receptors. For example semaglutide hits the GLP-1 receptor harder and longer than any other GLP-1 as it all it has to target. It is whatever drug has the best overall synergy with the different receptors. A bit over simplified, but that it is in a nutshell.

Either way, I think you are just fine with the reta. I haven't had too many people complain one way or another.

 

[hexagonal]

I swapped from tirz to reta.

For me, I have more energy on reta, and I have an easier time eating. Tirz I literally could not eat enough. Reta I feel like I'm fully in control of how much I eat.

It does increase my RHR more than tirz did.

 

[TarzanNRW]

Is reta available in Europe?

 

[Diixencider]

i like reta. i pin 2x a week at 3mg a pin for 6mg total weekly. Love the stuff

 

[BamaCrazy]

Tirz - better for weight loss than Reta. Superior hunger suppression. Eating was a boring chore and I would struggle to eat enough calories to make meaningful gains in the gym. I lost 45 pounds before switching to Reta.
Reta - I didn’t feel true hunger suppression on Reta. I felt in control of how much or how little I wanted to eat. It’s like being on a weight loss medication but feeling like you are not on a medication. Reta was the perfect GLP to switch to for maintenance and weightlifting.

 

[hexagonal]

Tirz - better for weight loss than Reta. Superior hunger suppression. Eating was a boring chore and I would struggle to eat enough calories to make meaningful gains in the gym. I lost 45 pounds before switching to Reta.
Reta - I didn’t feel true hunger suppression on Reta. I felt in control of how much or how little I wanted to eat. It’s like being on a weight loss medication but feeling like you are not on a medication. Reta was the perfect GLP to switch to for maintenance and weightlifting.

The reta trials have shown more weight loss over the shorter period than the tirz trials and without the plateaus (that's why they keep extending the phase 3s)

22.1% over 48 weeks for reta, 17.8% over 72 weeks for tirz.

I definitely am eating more on reta so I don't have a specific explanation here beyond the glucagon receptor activation increasing metabolism enough to more than balance it out.

 

[BamaCrazy]

The reta trials have shown more weight loss over the shorter period than the tirz trials and without the plateaus (that's why they keep extending the phase 3s)

22.1% over 48 weeks for reta, 17.8% over 72 weeks for tirz.

I definitely am eating more on reta so I don't have a specific explanation here beyond the glucagon receptor activation increasing metabolism enough to more than balance it out.

I had lost all the weight I wanted to lose by the time I switched to Reta. Tirz made weight loss easy because I couldn’t eat much, nor was I interested in eating. What I liked about Reta was I could eat too much and I still didn’t gain fat. It definitely does something to the metabolism.

 

[Naralol]

Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?.

Yup, just a bunch of people with no experience with diet and training who hop on glp1s who also have no self-control. Usually normies and tiktok mums

 

[17SS]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

I take both. 3mg Reta and 6mg Tirz every 4 or 5 days.

 

[Yugo92]

I take both. 3mg Reta and 6mg Tirz every 4 or 5 days.

Is there a proven advantage to combining Reta with Tirz? just curious

 

[BP_6]

Is there a proven advantage to combining Reta with Tirz? just curious

Proven? No just some bro science like so many other things. People experimenting.

Personally, I wouldn't mix GLP-1's, but if I had to, I would probably pick something like Maz, or survo to mix with my tirz. Both those compounds are showing very good results in trials and are kind of left in the dark with tirz and reta taking up all the spotlight.

 

[Ghoul]

Yup, just a bunch of people with no experience with diet and training who hop on glp1s who also have no self-control. Usually normies and tiktok mums

That's not what the facts show. 90%+ of people who successfully lose 10% + weight by traditional diets regain it within 5 years. They had the self control to pursue and achieve the loss by calorie restriction but an appetite that's malfunctioning and demanding excess calories can be as potent as a heroin or nicotine addiction. Most people will succumb to the pressure of an abundant food environment when they can't dedicate all their attention to battling an unrelenting appetite.

I hear a lot of anger toward GLPs from people who've been conditioned to think their properly functioning, or weak appetite, where their parents had to force their scrawny asses to eat, is some kind of superpower. There's a reason some people have to seek out appetite stimulants to be able to eat enough to put on gains.

 

[BP_6]

That's not what the facts show. 90%+ of people who successfully lose 10% + weight by traditional diets regain it within 5 years. They had the self control to pursue and achieve the loss by calorie restriction but an appetite that's malfunctioning and demanding excess calories can be as potent as a heroin or nicotine addiction. Most people will succumb to the pressure of an abundant food environment when they can't dedicate all their attention to battling an unrelenting appetite.

I hear a lot of anger toward GLPs from people who've been conditioned to think their properly functioning, or weak appetite, where their parents had to force their scrawny asses to eat, is some kind of superpower. There's a reason some people have to seek out appetite stimulants to be able to eat enough to put on gains.

I have stated before I don't get some of the hate I see for GLP-1 users. More often than not they are anabolic users themselves the ones putting them down.

It doesn't come across as trying to help anyone out either like, I don't think you need that. Why don't you try xyz to your max and make progress. Then if you are making progress then add them in as a little extra help. It is more of an "I am better than you" and a sense of self righteousness. I find it odd.

 

[Ghoul]

Is there a proven advantage to combining Reta with Tirz? just curious

Nothing proven, and I don't think it should be considered unless the max dose of a single compound proves insufficient. Even then, Sema and Tirz have increased doses(for poor responders) on the verge of approval, and are demonstrated safe. Up to 25mg Tirz and incredibly, 7.2mg sema. So there's more room for those compounds to be increased.

If someone feels like they must use an add on to Tirz or Reta, imo a tiny dose of Sema is the best route.

This way you're only boosting GLP agonism, the main appetite suppression mechanism, and not competing for GIP receptors against Reta or Tirz. GIP agonism varies greatly between these compounds. I wouldn't want to block a GIP receptor with Tirz, which replicates natural binding strength, from Reta which is 8x stronger when the difference is likely an important part of the "balance" in each of those compound's formula. .

 

[Ghoul]

I have stated before I don't get some of the hate I see for GLP-1 users. More often than not they are anabolic users themselves the ones putting them down.

It doesn't come across as trying to help anyone out either like, I don't think you need that. Why don't you try xyz to your max and make progress. Then if you are making progress then add them in as a little extra help. It is more of an "I am better than you" and a sense of self righteousness. I find it odd.

I hate to use this because it sounds so despicably "woke", but in many cases I think the resentment comes from "metabolic privledge". These days, my "self control" is used to choose healthy foods, and stop eating when I'm full. Previously, feeling full was rare, and the volume of food it took to get there was way beyond calorie requirements. You realize this is what the people who've never had to struggle experience. A normal appetite. So they assume anyone who's got excess weight must be forcing themselves to eat more out of sheer gluttony, persistent poor choices. and not an insatiable appetite.

As GLPs become more available though, not using them is a choice for many and inexcusable. Only 10% of people who qualify and have coverage are using them. So for that group, which is something like 70% of the overweight population in the US, there really is no excuse. Same goes for those who quit, which is common within the first year.

There's no justification for blasting the people using GLPs to get healthier and the body they want. They're willingly giving up the pleasure of food, suffering nasty side effects, and let's not forget, normal people are NOT excited about injecting themselves with anything, so they have to get over that too. The weight loss doesn't come without sacrifice, just a relief of psychological pressure so they have the bandwidth to make better choices.

 

[explodingHeart]

I have stated before I don't get some of the hate I see for GLP-1 users. More often than not they are anabolic users themselves the ones putting them down.

It doesn't come across as trying to help anyone out either like, I don't think you need that. Why don't you try xyz to your max and make progress. Then if you are making progress then add them in as a little extra help. It is more of an "I am better than you" and a sense of self righteousness. I find it odd.

I hate to use this because it sounds so despicably "woke", but in many cases I think the resentment comes from "metabolic privledge". These days, my "self control" is used to choose healthy foods, and stop eating when I'm full. Previously, feeling full was rare, and the volume of food it took to get there was way beyond calorie requirements. You realize this is what the people who've never had to struggle experience. A normal appetite. So they assume anyone who's got excess weight must be forcing themselves to eat more out of sheer gluttony, persistent poor choices. and not an insatiable appetite.

As GLPs become more available though, not using them is a choice for many and inexcusable. Only 10% of people who qualify and have coverage are using them. So for that group, which is something like 70% of the overweight population in the US, there really is no excuse. Same goes for those who quit, which is common within the first year.

There's no justification for blasting the people using GLPs to get healthier and the body they want. They're willingly giving up the pleasure of food, suffering nasty side effects, and let's not forget, normal people are NOT excited about injecting themselves with anything, so they have to get over that too. The weight loss doesn't come without sacrifice, just a relief of psychological pressure so they have the bandwidth to make better choices.

"The drugs I use are pure, good and moral."

"The drugs you use are evil, not natural, and are for cheaters."

 

[17SS]

Is there a proven advantage to combining Reta with Tirz? just curious

The Reta appetite suppression is weaker for me at lower dosages and I have a kit of Tirz I’m trying to finish off. My a1c is down to 4.7 so it’s definitely working.

 

[Ghoul]

"The drugs I use are pure, good and moral."

"The drugs you use are evil, not natural, and are for cheaters."

....it used to be much, much worse here.

A year ago if you wanted to be a lightning rod for hate say something positive about GLPs.

As someone who uses both, it was surreal arguing with people who had a religious fundamentalist level of anti-GLP zeal, because exogenous GLP hormones ( that's what they are) are a filthy "cheat" for the weak, while their use of exogenous hormones to achieve the body they want, often at the expense of health, was somehow noble.

The same rationale for anti-steroid hate from normies, "it's cheating!", was used by them against GLPs.

So many BBs have used them now, getting the "food noise gone" epiphany of just how biological the drive to eat is and not an issue of morality, that anti-GLP stuff is pretty rare now.

 

[Ghoul]

The Reta appetite suppression is weaker for me at lower dosages and I have a kit of Tirz I’m trying to finish off. My a1c is down to 4.7 so it’s definitely working.

Personally I think if you're using anything above physiologic doses of rHGH, it's foolish not to run a GLP to keep the strain off your beta cells. I can see the effects of growth hormone induced insulin resistance on my CGM, but glucose clearance post meal is very sharp and Tirz keeps me in a tight range consistently. I'm confident I could go long term without inducing pre-diabetes thanks to the protection the GLP provides.