MESO-Rx
Anabolic Steroids
The generic vs pharma GH discussion
- Thread starter justaphan
- Start date
AlexDavis43
Member
Half the time the ChatGPT isn't even relevant. But sure provides a good source from which to cherry pick.
Plus, there are people with actual real experience here. That trumps ChatGPT any day imo.
Great point! Should have included tertiary structure in the comments as well but this would be first trial and I am unsure the capability of the lab (far vs near UV). Jano offered to reach out to lab for more info.
Background:
Structure-function studies on human growth hormone. Evidence that tertiary structure is essential for biological activity - PubMed
The relationship between the conformation of human pituitary growth hormone (hGH), biological activity, and ligand binding activity was studied by comparing conformational details previously published on in vivo and in vitro studies of identical samples of hGH and its known derivatives. In vivo...
pubmed.ncbi.nlm.nih.gov
Non-native Intermediate Conformational States of Human Growth Hormone in the Presence of Organic Solvents - Pharmaceutical Research
Purpose. Manufacturing processes expose protein pharmaceuticals to organic solvents that may perturb the native folded state, increasing the potential for irreversible aggregation or surface adsorption. The aim of this study was to characterize the conformational states of human growth hormone...
link.springer.com
Most likely iterative in process as we learn more. The journey is the fun, right?
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BamaCrazy
Banned
lol. I know you are big money. Let’s do this!What? I'm not good for it?
AlexDavis43
Member
A poor IGF1 response doesn't always mean shit GH
BUT, a good IGF1 response is a decent indicator that it's not shit GH
Or conduct a million nerd tests
yes I know IGF1 isn't the only benefit of GH
BUT, a good IGF1 response is a decent indicator that it's not shit GH
Or conduct a million nerd tests
yes I know IGF1 isn't the only benefit of GH
Spaceman Spiff
Subscriber
I am sure readalot would.
Ghoul on the other hand talks about this shit and has not even posted any collected data of his own. Not even igf1 markers to reflect any type of "bio activity" it has on his igf1. (We know igf1 doesn't mean everything)
I have atleast compared igf1 and janos testing on serostim to QSC on paper for my trailer park customers. UGL HGH unfiltered with alot of aggregates causing immunogenicity doesnt seem to cause issues.
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brutalbuilt
Member
igf-1 blood test only shows whats in serum which doesn't mean shit for muscle
what matters is the igf-1 in muscle
Spaceman Spiff
Subscriber
Yeah but how do we even know that? It it's not really that relevant if we can't measure it
AlexDavis43
Member
Just having diarrhea of the mouth? That has nothing to do with the conversation.
TheScholarOfBrew
Banned
I will chip in! Sign me up. 100 bucks from everyone
brutalbuilt
Member
you got dementia? you forgot that you posted a comment about igf-1 grandpa
brutalbuilt
Member
get a biopsy to measure it in muscle
thats why you see skinny guys making no progress still test high igf-1
AlexDavis43
Member
So anytime someone says anything about IGF1 you drop the muscle IGF1 comment. Cool.
brutalbuilt
Member
you was talking about igf1 response to gh
Spaceman Spiff
Subscriber
Meh, I'll pass on my own muscle biopsy. Lol.
But some people like for real time data collection which is great
Status?
I was planning on getting some more Serostim so I could run head to head against a "premium" UG GH and a typical UG "generic" GH. The "premium" supposedly tests better against pharma standard with HPLC-MS. I don't have that data and vendor won't share it.
The price Jano quoted me was 400 USD for a pair wise comparison with CD and 600 USD for 3 samples. He stated this was no markup on his part with outside lab. I want to speak with this lab first if we go with CD to confirm near vs far UV and make sure it isn't a mess like the oil based endotoxin analyses.
If someone orders NMR then you are on your own as Jano doesn't have the bandwidth to interpret results and that ain't my thing. Do we have NMR guru here?
Hence CD is probably best incremental test we could pursue IMO. Interpretation is simple if you get the testing conditions right.
Fyi.
Thoughts/feedback?
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Spaceman Spiff
Subscriber
I like how he pretty much ignored your question to contribute to fucking harm reduction he has been preaching this whole time
Diixencider
Member
ill throw some money in
rockyraccoon
Member
I'll chip in if usdt is accepted.
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