Search results for query: Chlorobutyl

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...medicine cabinet, like Band-Aid. By the way, it’s not the BA or BB that’s responsible for leaching this out of raw bromobutyl and chlorobutyl, it’s oil. Raw rubber stoppers are Type I, suitable for water based injectable drugs, oil based injectables are supposed to use Type II, either...

Shitty bromobutyl stoppers are common from China. Pharma in the US uses chlorobutyl, and they have to perform "leachable/extractable" accelerated aging tests to make sure they won't transfer anything into the liquid. I think QSC wins the prize for the most trash stoppers on earth. Some would...

Was definately my initial concern. Sterilization temps for bromobutyl stopper is 249f and chlorobutyl 320f, for 20 minutes. So at 170f we're below the rubber stopper limits, Also well below temps that would boil or harm any of the active ingredients, oil, BA, and BB.

No stupid questions. Bromobutyl stoppers are fine up to 260f, Chlorobutyl to 270f. All of the ingredients, oil. BA, BB, and Test C, E, U, and every other AAS raw I'm familiar with are stable at 170-200F for reasonably long periods of times. Certainly up to an hour will have no consequential...

Benzyl Benzoate turns silicone to goo and causes chemicals to leech into the solution making it unsuitable. PTFE coated bromo or chloro butyl rubber is the ultimate non-reactive stopper, especially for long term storage.

Because: 1 - (the primary reason) In the US, every medical product must have an NDC registration number and an expiration date by law. 2 - The chlorobutyl stopper and plastic bottle will eventually leach chemicals into the liquid, which can interact with the meds being reconstituted.

...About $1.50 each. Perhaps some "harm reduction" minded, motivated person will start a group buy to reach the minimum quantity necessary to buy them: https://www.westpharma.com/shop/20mm-novapure-chlorobutyl-serum-rubber-stoppers-4432-50/19700305

...5 minutes work: It's literally available from the manufacturer. with worldwide shipping. https://www.westpharma.com/shop/20mm-novapure-chlorobutyl-serum-rubber-stoppers-4432-50/19700305[ $750 for 500 too much? Available from dozens of science supply surplus sites, like this one...

...arteriosclerosis, granuloma, pulmonary embolism and other adverse reactions butyl plugs are one of the main factors of particle contamination of infusion preparations," https://www.xiangyiintl.com/news-what-is-the-difference-between-chlorobutyl-rubber-plugs-and-bromobutyl-rubber-plugs.html

...in an oven at 160c for 2 hours" is verifying which compounds besides Test can withstand this temp, and which stoppers are compatible. Chlorobutyl stoppers is what USP advises compounders to use for injectables getting Terminally Sterilized because it's more heat resistant, but Bromobutyl...